Search results for "ATAL"
showing 10 items of 10591 documents
Indagini genetiche e trattamenti prenatali in utero della Sindrome Adreno Genitale (SAG) in una Coorte Siciliana.
2008
La deficienza dell'enzima 21 idrossilasi (21OHD) è la causa più comune di sindrome adrenogenitale (SAG). Il gene implicato è il CYP21 (6p21.3). La SAG è un problema clinico-sociale in quanto nel 95% dei casi genera l'iperandrogenismo dei neonati di sesso femminile. Il trattamento più effettuato in corso di virilizzazzione dei genitali femminili esterni è di tipo chirurgico (genitoplastica). Il trattamento prenatale in utero è una alternativa medica con il fine di compensare il difetto enzimatico e prevenire l'eccesso di androgeni in corso di morfogenesi fetale. Un nuovo protocollo diagnostico-terapeutico prenatale è stato sviluppato sulla base di una terapia precoce (alla 5° WG) con Desamet…
Materials for depollution based on the model of manganese dioxygenase
2013
La utilización intensiva de pesticidas ha traído consigo la presencia de una gran cantidad de moléculas contaminantes en aguas y suelos. Los tratamientos para degradar estas moléculas son caros, por lo que es de gran interés la búsqueda de soluciones más baratas. En el caso de los catecoles, existen enzimas, las catecol-dioxigenasas, que abren el ciclo aromático por oxidación con dioxígeno. Las condiciones suaves y la gran disponibilidad de este oxidante podrían ofrecer una solución para esos problemas de polución. El objetivo de este trabajo de tesis es mimetizar un tipo particular de dioxigenasa, la dioxigenasa de manganeso. Dado que tanto la primera esfera de coordinación como la segunda…
Suomen sähköntuotannon taloudelliset ja biofysikaaliset kustannukset ja skenaarioita fossiilisista energialähteistä irtautumiselle
2010
Maailman energiajärjestelmä perustuu fossiilisen energialähteiden laajamittaiseen hyödyntämiseen, mikä lisää ilmakehän hiilidioksidipitoisuutta ja kiihdyttää siten globaalia ilmastonmuutosta. Energian kysynnän kasvun ennustetaan jatkuvan tulevina vuosikymmeninä, mutta samalla fossiilisten energialähteiden resurssit käyvät yhä niukemmiksi, mikä pahentaa kysynnän ja tarjonnan välistä kuilua ja nostaa polttoaineiden hintoja. Siirtyminen pois fossiilisten energialähteiden käytöstä on siten välttämätöntä sekä ympäristöllisistä että saatavuuteen liittyvistä syitä. Osa taloustieteilijöistä on käyttänyt sekä taloudellista että biofysikaalista analyysia luonnonvarojen ja ihmisen hallitsemien prosess…
Hopes and Limits of Adipose-Derived Stem Cells (ADSCs) and Mesenchymal Stem Cells (MSCs) in Wound Healing
2020
Adipose tissue derived stem cells (ADSCs) are mesenchymal stem cells identified within subcutaneous tissue at the base of the hair follicle (dermal papilla cells), in the dermal sheets (dermal sheet cells), in interfollicular dermis, and in the hypodermis tissue. These cells are expected to play a major role in regulating skin regeneration and aging-associated morphologic disgraces and structural deficits. ADSCs are known to proliferate and differentiate into skin cells to repair damaged or dead cells, but also act by an autocrine and paracrine pathway to activate cell regeneration and the healing process. During wound healing, ADSCs have a great ability in migration to be recruited rapidly…
Addition of Ethylene or Hydrogen to a Main-Group Metal Cluster under Mild Conditions
2015
Reaction of the tin cluster Sn8(Arinline image)4 (Arinline image=C6H2-2,6-(C6H3-2,4,6-Me3)2) with excess ethylene or dihydrogen at 25 °C/1 atmosphere yielded two new clusters that incorporated ethylene or hydrogen. The reaction with ethylene yielded Sn4(Arinline image)4(C2H2)5 that contained five ethylene moieties bridging four aryl substituted tin atoms and one tin–tin bond. Reaction with H2 produced a cyclic tin species of formula (Sn(H)Arinline image)4, which could also be synthesized by the reaction of {(Arinline image)Sn(μ-Cl)}2 with DIBAL-H. These reactions represent the first instances of direct reactions of isolable main-group clusters with ethylene or hydrogen under mild conditions…
Trapping and Reactivity of a Molecular Aluminium Oxide Ion
2019
Aluminium oxides constitute an important class of inorganic compound that are widely exploited in the chemical industry as catalysts and catalyst supports. Due to the tendency for such systems to aggregate via Al‐O‐Al bridges, the synthesis of well‐defined, soluble, molecular models for these materials is challenging. Here we show that reactions of the potassium aluminyl complex K 2 [( NON )Al] 2 ( NON = 4,5‐bis(2,6‐diiso‐propylanilido)‐2,7‐di‐tert‐butyl‐9,9‐dimethylxanthene) with CO 2 , PhNCO and N 2 O all proceed via a common aluminium oxide intermediate. This highly reactive species can be trapped by coordination of a THF molecule as the anionic oxide complex [( NON )AlO(THF)] ‐ , which …
Low‐Valent Germanylidene Anions: Efficient Single‐Site Nucleophiles for Activation of Small Molecules
2021
Abstract Rare mononuclear and helical chain low‐valent germanylidene anions supported by cyclic (alkyl)(amino)carbene and hypermetallyl ligands were synthesised by stepwise reduction from corresponding germylene precursors via stable and isolable germanium radicals. The electronic structures of the anions can be described with ylidene and ylidone resonance forms with the Ge−C π‐electrons capable of binding even weak electrophiles. The germanylidene anions reacted with CO2 to give μ‐CO2‐κC:κO complexes, a rare coordination mode for low‐valent germanium and inaccessible for the related neutral germylones. These results implicate low‐valent germanylidene anions as efficient single‐site nucleop…
Leiomyoma of the hard palate : a case report
2007
Leiomyoma is a benign smooth muscle tumor that is very rarely located in the oral cavity. It is accepted that the smooth muscle giving rise to this tumor corresponds to the tunica media of the arteries. The tumor can develop at any age, with no clear gender predilection, and typically manifests as a slow-growing, asymptomatic lesion. The diagnosis is based on the histopathological study, with the use of specific staining techniques, including immunohistochemical markers. Treatment consists of complete resection of the lesion, with due safety margins. We present the case of a 57-year-old male with a tumor located for the previous four months in the region of the hard palate, adjacent to the …
Audit Institutions in the European Union: Public Service Promotion, Environmental Engagement and COVID Crisis Communication through Social Media
2020
This article analyses Social Media (SM) use as a promotion tool for public institutions in the public audit sector. The authors propose a quantitative model to assess online engagement of 94 European audit institutions (national and regional) with their stakeholders, based on SM and web activity metrics of these institutions, with a focus on pressing matters such as environment, sustainability and the current COVID pandemic. The proposed model may be applied to assess organisations from any public or private sector. The research finds that SM presence helps audit institutions to promote their services more effectively by directing their stakeholders to extensive content on the audit institu…
Fallibilità o meno delle società in house tra diritto privato e diritto pubblico, garanzia statale dei debiti degli enti pubblici (CEDU) e divieto di…
2014
L'articolo affronta la complessa tematica della disciplina giuridica applicabile alle società in house, specie sotto il profilo della assoggettabilità a fallimento,in un quadro più ampio che coinvolge un inedito intreccio tra CEDU e diritto UE.