Search results for "ATS"
showing 10 items of 6881 documents
Pētnieciskās darbības iespējas patstāvības veicināšanai skolēniem sākumskolā
2021
Bakalaura darba autore: Linda Veltheima. Bakalaura darba nosaukums: “Pētnieciskās darbības iespējas patstāvības veicināšanai skolēniem sākumskolā”. Darba mērķis: teorētiski izpētīt un praktiski pārbaudīt sākumskolas skolēnu patstāvību veicinošas darbības pētnieciskā procesa laikā sākumskolā. Darba uzdevumi ir: 1.Analizēt zinātnisko literatūru un informācijas avotus par pētnieciskās darbības nozīmi pastāvības veicināšanai sākumskolas skolēniem. 2.Teorētiski analizēt patstāvību veicinošas darbības nozīmi pētnieciskā procesa laikā un izstrādāt to raksturojošus kritērijus un rādītājus. 3.Veikt empīrisku pētījumu par patstāvību veicinošām darbībām un to nozīmi pētnieciskā procesa laikā. Darba pi…
Le non-renvoi des QPC. Unité ou diversité des pratiques de la Cour de cassation et du Conseil d'État
2018
ISBN : 978-2-37032-164-0; National audience; L'étude du non-renvoi des questions prioritaires de constitutionnalité (QPC) par les Cours suprêmes présente un caractère singulier à bien des égards et notamment car elle touche à l'office du juge ; à son discours et au contrôle des lois par rapport à la norme suprême. Aussi surprenant soit-il, et bien que le mécanisme de la QPC soit effectif depuis le 1er mars 2010, aucune analyse globale n'a été réalisée sur cette problématique, alors même qu'elle permettrait de préciser le contenu des modalités de renvoi qui conditionnent les chances de succès des recours ; de délimiter l'office des Cours suprêmes, et d'observer le cas échéant, son élargissem…
Anàlisi dels qüestionaris d'avaluació docent de les universitats públiques espanyoles sota el marc de l'Espai Europeu d'Educació Superior. Què avalua…
2015
La investigació col•labora en la reflexió teòrica sobre el perfil del bon professorat universitari des de 1936 fins a l’actualitat, si bé centra l’atenció en els models formulats a partir de competències docents en l’àmbit de l’Espai Europeu d’Educació Superior (EEES). No hi ha cap dubte que estem experimentant un altre model d’universitat al qual s’haurà d’acomodar un nou perfil docent que implique l’alumnat en un procés d’aprenentatge més madur i autònom. L’estudi centra el seu interès en l’anàlisi de la correspondència que existeix entre els models teòrics més recents i el perfil docent que les universitats públiques espanyoles prenen com a referència als qüestionaris d’avaluació que l’e…
Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
2011
Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro. Protection by lovastatin is related to inhibition of the Ras-homologous GTPase Rac1. It rests on a reduced formation of DNA double-strand breaks, resulting from the inhibition of topoisomerase II by doxorubicin. Doxorubicin transport and reactive oxygen species are not involved. Protection by lovastatin was confirmed in vivo. I…
Tiam1 as a Signaling Mediator of Nerve Growth Factor-Dependent Neurite Outgrowth
2010
Nerve Growth Factor (NGF)-induced neuronal differentiation requires the activation of members of the Rho family of small GTPases. However, the molecular mechanisms through which NGF regulates cytoskeletal changes and neurite outgrowth are not totally understood. In this work, we identify the Rac1-specific guanine exchange factor (GEF) Tiam1 as a novel mediator of NGF/TrkA-dependent neurite elongation. In particular, we report that knockdown of Tiam1 causes a significant reduction in Rac1 activity and neurite outgrowth induced by NGF. Physical interaction between Tiam1 and active Ras (Ras- GTP), but not tyrosine phosphorylation of Tiam1, plays a central role in Rac1 activation by NGF. In add…
Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons.
2012
To investigate the potency of the topoisomerase II (topo II) poisons doxorubicin and etoposide to stimulate the DNA damage response (DDR), S139 phosphorylation of histone H2AX (γH2AX) was analyzed using rat cardiomyoblast cells (H9c2). Etoposide caused a dose-dependent increase in the γH2AX level as shown by Western blotting. By contrast, the doxorubicin response was bell-shaped with high doses failing to increase H2AX phosphorylation. Identical results were obtained by immunohistochemical analysis of γH2AX focus formation, comet assay-based DNA strand break analysis, and measuring the formation of the topo II-DNA cleavable complex. At low dose, doxorubicin activated ataxia telangiectasia m…
First Ruthenium Complex of Glyoxalbis(N-phenyl)osazone (LNHPhH2): Synthesis, X-ray Structure, Spectra, and Density Functional Theory Calculations of …
2007
The first ruthenium complex containing the parent osazone ligand, glyoxalbis(N-phenyl)osazone (LNHPhH2), is reported. The complex (LNHPhH2)Ru(PPh3)2Cl2 (1) was characterized with mass, IR, 1H NMR, and UV−vis spectroscopy as well as with theoretical calculations. Density functional theory calculations on the model compound (LNHPhH2)Ru(PMe3)2Cl2 (2) reproduce the geometrical features observed for 1 and verify that it formally contains a ruthenium(II) metal center coordinated by a neutral osazone. Subsequent bonding analyses identify π-interactions between the occupied orbitals of the metal fragment and the LUMO of the osazone, which results in transfer of approximately 0.3 electrons from the …
Theoretical investigation of paramagnetic group 13 diazabutadiene radicals: insights into the prediction and interpretation of EPR spectroscopy param…
2006
The electronic structures and the spin density distributions of the group 13 1,4-diaza(1,3)butadiene (DAB) radicals [(R-DAB)2M]˙, [(R-DAB)MX2]˙ and {[(R-DAB)MX]2}˙˙ (M = Al, Ga, In; X = F, Cl, Br, I; R = H, Me, tBu, Ph) are studied using density functional theory at both non-relativistic and relativistic levels of theory. The calculations demonstrate that all systems share a qualitatively similar electronic structure and are primarily ligand centred π-radicals. The calculated metal, nitrogen and hydrogen hyperfine couplings are found to be independent of the identity of the R-group and the halogen atom. They are, however, dependent on the geometry and oxidation state of the metal centre. Bo…
Theoretical Investigation of Paramagnetic Diazabutadiene Gallium(III)−Pnictogen Complexes: Insights into the Interpretation and Simulation of Electro…
2005
The electronic structures and the spin density distributions of the paramagnetic gallium 1,4-diaza(1,3)butadiene (DAB) model systems {(tBu-DAB)Ga(I)[Pn(SiH3)2]}• and the related dipnictogen species {(tBu-DAB)Ga[Pn(SiH3)2]2}• (Pn = N, P, As) were studied using density functional theory. The calculations demonstrate that all systems share a qualitatively similar electronic structure and are primarily ligand-centered π-radicals. The calculated electron paramagnetic resonance (EPR) hyperfine coupling constants (HFCCs) for these model systems were optimized using iterative methods and were used to create accurate spectral simulations of the parent radicals {(tBu-DAB)Ga(I)[Pn(SiMe3)2]}• (Pn = N, …
Raganas tēla vizuālā interpretācija
2019
Raganas tēls ir plaši pazīstams mākslā un to ataino dažādos veidos - no ļaunās, vecās, negantās raganas līdz pavedinošai skaistulei un beidzot ar labestīgu, gudru raganu. Diplomdarba galvenais pētījuma priekšmets ir raganas tēla vizuālā interpretācija un tā atainojums grāmatu ilustrācijās. Teorētiskās un empīriskās daļas galvenais uzdevums ir apkopot un analizēt literatūru par raganas tēla vizuālo interpretāciju mākslā un grāmatu ilustrācijās, kā arī analizēt apkopotos grāmatu ilustrāciju paraugus. Tika secināts, ka raganas tēls mākslā parādījās tikai ar jauno laiku sākumu, kad reliģijai bija spēcīga ietekme un mākslas darbi bija atgādinājums sabiedrībai par raganu ļaunumu, ķecerību un iesp…