Search results for "ATS"
showing 10 items of 6881 documents
Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway.
2003
Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that mediate phospholipase D (PLD) activation in brain, but the mechanism underlying this response remains unclear. Here we used primary cultures of astrocytes as a cell model to explore the mechanism that links mGluRs to PLD. Glutamate activated both phospholipase C (PLC) and PLD with equal potency and this effect was mimicked by L-cysteinesulfinic acid, a putative neurotransmitter previously shown to activate mGluRs coupled to PLD, but not PLC, in adult brain. PLD activation by glutamate was dependent on Ca(2+) mobilization and fully blocked by both protein kinase C (PKC) inhibitors and PKC down-regulation, suggesti…
Chronic ethanol exposure alters the levels, assembly, and cellular organization of the actin cytoskeleton and microtubules in hippocampal neurons in …
2010
The organization and dynamics of microtubules (MTs) and the actin cytoskeleton are critical for the correct development and functions of neurons, including intracellular traffic and signaling. In vitro ethanol exposure impairs endocytosis, exocytosis, and nucleocytoplasmic traffic in astrocytes and alters endocytosis in cultured neurons. In astrocytes, these effects relate to changes in the organization and/or function of MTs and the actin cytoskeleton. To evaluate this possibility in hippocampal cultured neurons, we analyzed if chronic ethanol exposure affects the levels, assembly, and cellular organization of both cytoskeleton elements and the possible underlying mechanisms of these effec…
Inhibition of Rho modulates cytokine-induced prostaglandin E2 formation in renal mesangial cells.
2003
Stimulation of rat mesangial cells for 24 h with interleukin-1β(IL-1β) plus forskolin (Fk) leads to a marked increase in prostaglandin E 2 (PGE 2 ) synthesis. This effect is further enhanced by the small G-protein Rho inhibitor toxin A. A similar increase in PGE 2 formation is obtained with Y27632, a Rho-dependent kinase inhibitor, and with lovastatin, a hydroxymethylglutaryl-coenzyme A inhibitor which depletes cells from geranylgeranyl moieties and thus blocks Rho activation. In parallel to the increased PGE 2 synthesis, a potentiation of IL-1β-induced secretory group IIA phospholipases A 2 (sPLA 2 -IIA) protein expression also occurs by Rho inhibition. However, only toxin A triggers an in…
2-3 gadus vecu bērnu patstāvības sekmēšanas iespējas rotaļdarbībās pirmsskolā
2020
Kvalifikācijas darba mērķis ir teorētiski izzināt, analizēt un praktiski pētīt bērnu patstāvības sekmēšanas iespējas rotaļdarbībās pirmsskolā. Pētījuma metodes: 1. Teorētiskās: teorētiskās literatūras un citu avotu salīdzinoša analīze, datu analīze 2. Praktiskās: novērojums, anketēšana, sarunas ar pedagogiem un vecākiem. Kvalifikācijas darbs sastāv no divām daļām: teorētiskā un praktiskās. Teorētiskā pamatojuma izstrādei tika izmantotas A.Bikovas, I.Stangaines, D.Dzinteres, G.Svences u.c. autoru atziņas par rotaļdarbību izmantošanas iespējām jaunākā vecuma bērnu patstāvības sekmēšanā. Praktiskā pētījuma bāze: Madonas pirmsskolas izglītības iestādes pedagogi, 1.vecumposma bērni un viņu vecāk…
Sleepless in Carver Country: Insomnia and Existential Crisis in Raymond Carver’s Short Fiction
2020
Chez Raymond Carver, la nuit n’est jamais uniquement une toile de fond réaliste. Dans ses nouvelles se déroulant après la tombée de la nuit, Carver joue à déconstruire les clichés généralement associés au confort de l’intimité nocturne et du lit conjugal. L’insomnie qui frappe certains de ses personnages les renvoie au contraire à leur complète solitude et à leur condition de mortels. Cet article cherche donc à voir comment la nuit blanche carvérienne est utilisée métaphoriquement pour exprimer l’angoisse de personnages souvent peu expansifs, qui veulent leur part du Rêve américain mais se retrouvent pris au piège d’un cauchemar existentiel. In Raymond Carver’s short fiction, the night is n…
Un 'sujet qui fâche' : l'évaluation des enseignants en France, entre défense statutaire, injonction au professionnalisme et autonomie professionnelle
2017
International audience; Cet article analyse les projets de réforme de l’évaluation des enseignants en France depuis la fin des années 1990 ainsi que les réactions, notamment syndicales, qu’ils ont suscitées. Cette évaluation est considérée comme un analyseur privilégié pour étudier les réactions des enseignants au développement de nouvelles politiques de reddition de comptes. A partir de méthodes qualitatives (entretiens, analyse de dépêches de presse et de corpus de documents), il étudie plus spécifiquement les systèmes de négociation des différents projets de réforme d’une évaluation régulièrement contestée mais jamais réformée au moment où nous terminons cet article. Adoptant une perspec…
Rúbriques FEC IV Fisioteràpia: Vojta
2021
Rúbriques de Vojta de l'assignatura Fisioteràpia en especialitats clíniques IV de 3er del Grau de Fisioteràpia
Saamenkielinen kirjahistoria Suomessa
2017
Suomessa kirjahistoria on pyrkinyt tarkastelemaan vanhaa suomenkielistä kirjallisuutta. Sen sijaan Suomen saamelainen kirjahistoria on jäänyt varjoon. Syynä voi olla sen hidas kehitys, joka alkoi paljon myöhemmin ja katkonaisemmin. Ensimmäisille saamennetuille kirjoille myönnettiin painolupa vasta kaksi sataa vuotta ensimmäisten saamenkielisten teosten julkaisemisen jälkeen. nonPeerReviewed
Ultrasound bioeffects in rats: quantification of cellular damage in the fetal liver after pulsed Doppler imaging
2011
Objective To determine whether pulsed Doppler examination of the ductus venosus in rat fetuses could damage exposed tissue. Methods On gestational day 18, the livers of a mean of approximately five fetuses per mother (n = 5.14, SD = 1.6), in a cohort of 35 pregnant female rats, were exposed individually to pulsed Doppler and these were considered the 'exposed group'. The remaining fetuses in each pregnant rat (n = 5.16, SD = 2.1) formed the 'control group'. We tested for 600, 300, 60, 20, 15, 10 and 3 s of exposure of the fetal ductus venosus and the damage was evaluated measuring a cell death index of apoptotic activity at 7 h post-exposure (n = 16). In addition, subgroups of mothers were …
The shape of the liquid plain: sicilian salt flats
2019
This paper analyzes the salt flats as a place for the mixing of knowledge and experiences that originate and substantiate life: from the application of physical, chemical and biological principles to produce salt, to economic laws to regulate sales and trade, to aspects socio-anthropological aspects underlying the life of the communities that worked in production. A patrimony of material and immaterial overlaps, generated by the redesign of a segment of territory with physical and positional characteristics median between sea and land, and in which man strives to obtain fundamental resources for his livelihood. Given the complex moment of crisis and gradual abandonment that these particular…