Search results for "AVAS"
showing 10 items of 428 documents
BANΔIT: B’‐factor Analysis for Drug Design and Structural Biology
2020
The analysis of B‐factor profiles from X‐ray protein structures can be utilized for structure‐based drug design since protein mobility changes have been associated with the quality of protein‐ligand interactions. With the BANΔIT (B’‐factor analysis and ΔB’ interpretation toolkit), we have developed a JavaScript‐based browser application that provides a graphical user interface for the normalization and analysis of B’‐factor profiles. To emphasize the usability for rational drug design applications, we have analyzed a selection of crystallographic protein‐ligand complexes and have given exemplary conclusions for further drug optimization including the development of a B’‐factor‐supported pha…
Defense-related gene expression in two olive cultivars inoculated with Pseudomonas savastanoi pv. savastanoi
2014
Reāllaika analīzes funkcionalitātes izstrāde datu noliktavai
2019
Šī maģistra darba mērķis ir izstrādāt reāla laika datu noliktavas arhitektūru un realizēt tai atbilstošu risinājumu kā koncepta pierādījumu. Darba ietvaros ir īsumā aprakstītas tipiskas datu noliktavas un pamatota reāla laika datu noliktavu nepieciešamība. Darba turpinājumā tika apkopota pieejamā akadēmiskā informācija par metodēm, kuras var izmantot, reāla laika datu noliktavu izstrādē. Darbā ir sniegts augsta līmeņa eksistējošās statiskās datu noliktavas apraksts, kā arī detalizēts reāla laika analīzei pielāgoto datu noliktavas izpildes pamatrādītāju ETL process. Turpinājumā ir detalizēti aprakstīta izstrādātā reāla laika risinājuma arhitektūra un tā izstrādes process, izmantojot rīku Ora…
Nonexposed Variant of Bisphosphonate-associated Osteonecrosis of the Jaw: A Case Series
2010
Abstract Purpose To report a case series of patients with the nonexposed variant of bisphosphonate-associated osteonecrosis of the jaw—a form of jaw osteonecrosis that does not manifest with necrotic bone exposure/mucosal fenestration. Methods Among 332 individuals referred to 5 clinical centers in Europe because of development of jawbone abnormalities after or during exposure to bisphosphonates, we identified a total of 96 patients who presented with the nonexposed variant of osteonecrosis. Relevant data were obtained via clinical notes; radiological investigations; patients' history, and referral letters. Results The most common clinical feature of nonexposed osteonecrosis was jaw bone pa…
Brief an Garlieb H. Merkel
1799
Ms. 930a, Nr. 8, Bl. 22r-23v Böttiger, Karl August. Brief an Garlieb H. Merkel, Weimar, d[en] 13. November 1797 Autora rokraksts / Autograph, vācu, angļu un latīņu val. / Deutsch, Englisch und Latein [4] lpp. / S. Attēlu numuri / Bildnummern: 930a-008-1 – 930a-008-4 Der Verfasser nennt in diesem inhaltsreichen Brief zahlreiche Namen und hält nicht nur die Verbindung mit Merkel, die aus dessen erstem Aufenthalt in Weimar resultierte, aufrecht, sondern gibt ihm weitere Hinweise und Empfehlung für seinen weiteren Aufenthalt in Dänemark. So rät er zur Übersetzung dreier Romane aus dem Englischen, darunter Jane Wests „A gossip's story“ (London 1796). Ferner bittet der Verfasser Merkel um Gefälli…
Uzņēmuma "Parking Spot" dibināšana
2018
Maģistra darba mērķis ir jauna uzņēmuma Parking Spot SIA dibināšana un šī uzņēmuma finanšu plāna izstrāde. Mūsdienu dinamiskajā vidē preču transportēšanas pakalpojumiem ir būtiska loma. Ik gadu tiek veikti infrastruktūras uzlabošanas darbi un tiek aktualizēts jautājums par pārvadājumu efektivitāti. Pēdējos gados uzmanību pievērš arī transportēšanas pakalpojumu palīgdarbībām, kas ir arī stāvvietas pakalpojumu nodrošināšana. Latvijā ir pieejamas vairākas bezmaksas stāvvietas kravas automašīnām, bet tās vairs neatbilst mūsdienu prasībām. Projekta ideja ir izveidot uzņēmumu, kas sniedz maksas stāvvietas pakalpojumu kravas automašīnām. Tas atšķirsies no parastajām stāvvietām ar to, ka tā būs aps…
Vascular changes after vitrectomy for rhegmatogenous retinal detachment: optical coherence tomography angiography study
2020
Purpose: To analyse the postoperative foveal avascular zone (FAZ) area, superficial vessel density (SVD) and deep vessel density (DVD) and their correlation with functional (best-corrected visual acuity, BCVA) and anatomical outcomes (foveal macular thickness, FMT) after surgery for rhegmatogenous retinal detachment (RRD) repair. Method: Patients with RRD eyes, successfully treated with a single pars plana vitrectomy (PPV) with gas tamponade and a minimum 12 months follow-up, were re-examined. Foveal avascular zone (FAZ) area, SVD, DVD and FMT were evaluated by using optical coherence tomography angiography (OCTA) and compared to fellow eye. Results: Fifty-six patients with macula-on and 37…
Neonatal form of nemaline myopathy, muscle immaturity, and a microvascular injury.
1990
An infant with a neonatal form of nemaline myopathy showed ultrastructural features of muscle immaturity. Immaturity was characterized by an abnormal presence of myotubes, as well as cells in clusters within a common basement membrane and a great number of satellite cells adhering to very small muscle fibers. In addition, degenerative changes and a severe microvascular lesion were observed. The pathologic findings in the muscle of this patient were those of neonatal nemaline myopathy complicating severe microvascular injury, possibly induced by an unknown toxic agent. ( J Child Neurol 1990;5:122-126).
Tumour-cell-endothelial interactions: free radicals are mediators of melanoma-induced endothelial cell damage
1996
Damage to vascular endothelium may play an important role during metastasis. We used a three-dimensional model of tumour cell extravasation to test the hypothesis that certain types of tumour cells are able to induce vascular endothelial cell injury. Multicellular tumour spheroids (MCTS) of 14 human cancer cell lines and spheroids from two benign cell lines were transferred onto confluent monolayers of human endothelial cells (EC). MCTS from 4 of 7 melanoma cell lines induced damage of the endothelium which was closely associated with tumour cell attachment. Endothelial cell injury became evident morphologically by loss of cell membrane integrity and sensitivity to shear stress. Similar res…
The “mode” of lymphocyte extravasation through HEV of Peyer's patches and its role in normal homing and inflammation
2007
The mode of lymphocyte transendothelial migration in the postcapillary high endothelial venules (HEVs) of Peyer's patches during normal homing and acute inflammation in the guinea pig was studied. It is common opinion that the lymphocyte transendothelial passage from the blood stream into the extravasal lymphoid tissue calls for a multistep process of endothelial and lymphocyte molecules favoring tethering, rolling, activation, arrest and its firm adhesion to the endothelial luminal surface. Ultrastructural serial pictures and the three-dimensional reconstruction of HEVs with lymphocytes during different moments of their transmigration through the endothelial wall enabled us to demonstrate …