6533b7d1fe1ef96bd125c2a1

RESEARCH PRODUCT

Neonatal form of nemaline myopathy, muscle immaturity, and a microvascular injury.

Anna FidziańskaHans H. GoebelMarion Kleine

subject

Pathologymedicine.medical_specialtyMuscle HypotoniaBiopsyIschemiaBiologyMuscle Smooth VascularLesion03 medical and health sciences0302 clinical medicineNemaline myopathyMyofibrilsIschemia030225 pediatricsBiopsymedicineHumansBasement membraneInclusion BodiesAsphyxia NeonatorumRespiratory Distress Syndrome Newbornmedicine.diagnostic_testMyogenesisMicrocirculationMusclesInfant NewbornDisseminated Intravascular Coagulationmedicine.diseaseMicroscopy ElectronMuscular Atrophymedicine.anatomical_structurePediatrics Perinatology and Child HealthMuscle HypotoniaFemaleNeurology (clinical)medicine.symptomMyofibril030217 neurology & neurosurgery

description

An infant with a neonatal form of nemaline myopathy showed ultrastructural features of muscle immaturity. Immaturity was characterized by an abnormal presence of myotubes, as well as cells in clusters within a common basement membrane and a great number of satellite cells adhering to very small muscle fibers. In addition, degenerative changes and a severe microvascular lesion were observed. The pathologic findings in the muscle of this patient were those of neonatal nemaline myopathy complicating severe microvascular injury, possibly induced by an unknown toxic agent. ( J Child Neurol 1990;5:122-126).

yearjournalcountryeditionlanguage
1990-04-01Journal of child neurology
10.1177/088307389000500209https://pubmed.ncbi.nlm.nih.gov/2161030