Search results for "AXL"

Laser Ultrasonics Inspection for Defect Evaluation on Train Wheel

2019

Abstract Passengers’ safety and in-service life of wheelset axles play an important role in railway vehicles. For this reason, periodic inspections are necessary. Among non-destructive techniques, ultrasonic ones are widely applied in this field. The main disadvantage of conventional ultrasonic techniques is that the overall inspection of wheels requires the train to be put out-of-service and disassembly each part, which is time-consuming and expensive. In this paper, a non-conventional non-contact laser ultrasonic inspection for train wheels is proposed. The proposed method uses a laser interferometer to receive the ultrasonic wave without contact. The receiving system allows choosing the …

The soluble form of pan-RTK inhibitor and tumor suppressor LRIG1 mediates downregulation of AXL through direct protein–protein interaction in gliobla…

2019

Abstract Background Targeted approaches for inhibiting epidermal growth factor receptor (EGFR) and other receptor tyrosine kinases (RTKs) in glioblastoma (GBM) have led to therapeutic resistance and little clinical benefit, raising the need for the development of alternative strategies. Endogenous LRIG1 (Leucine-rich Repeats and ImmunoGlobulin-like domains protein 1) is an RTK inhibitory protein required for stem cell maintenance, and we previously demonstrated the soluble ectodomain of LRIG1 (sLRIG1) to potently inhibit GBM growth in vitro and in vivo. Methods Here, we generated a recombinant protein of the ectodomain of LRIG1 (sLRIG1) and determined its activity in various cellular GBM mo…

María Magdalena. Continuidad y variación en la cultura audiovisual (1897-2014)

2017

El objetivo principal de esta tesis consiste en analizar la presencia de María Magdalena en las producciones audiovisuales del periodo comprendido entre 1897 y 2014. Dichas producciones proceden de Europa, Estados Unidos, Canadá y México. El marco metodológico general a partir del que se plantea el análisis es la iconología, entendida como Zwichenraum o tierra de confluencias. En concreto, la noción de continuidad y variación, iniciada por Aby Warburg y continuada por Fritz Saxl, es la principal cuestión teórica en la que se basa la aproximación. El estudio se lleva a cabo en perspectiva diacrónica con el objetivo de detectar dichas fases de continuidad y variación del personaje a lo largo …

Correction of Long Vehicle Off Tracking by Multiple Axle Steering

2019

When planning the road vehicles for the transport of passengers or goods, engineers should take care to contrast some undesirable phenomena in the lateral dynamics, such as high-speed instability or off tracking. While the former is less troubling in the slow heavy vehicles, the latter is a serious problem due to the risk of invading the neighbouring lanes. The use of multi-wheel steering may completely cancel this drawback and, pursuing an optimized correlation among the steering angles, a functional inter-dependence based on the cubic “witch of Agnesi” is found to be very promising. Simple control systems with electromechanical or electronic components may be easily implemented for the mu…

[3]Rotaxanes and [3]pseudorotaxanes with a rigid two-bidentate chelate axle threaded through two coordinating rings

2009

New [3]rotaxanes and [3]pseudorotaxanes have been synthesised using the “gathering and threading” effect of copper(I). By using click chemistry as the “stoppering” reaction, a good yield of the [3]rotaxane was obtained, either as a dicopper complex or as a metal-free compound after demetallation. The axle contains a central rigid aromatic block incorporating two bidentate chelates, and the threaded macrocycles are 30-membered rings. A model dicopper(I) [3]pseudorotaxane whose axle was end-functionalised by triisopropylsilyl groups could be crystallised and studied by X-ray diffraction. A particularly attractive structure was obtained showing a “slanted” geometry for the two rings and the ax…

A stepper motor-driven microelectrode positioner

1987

The mechanical elements and the electronic control system from a stepper motor-driven microelectrode positioner is described. The unit embodies a high-precision small step angle hybrid motor. The compact, rugged and totally concentric design of the mechanic, by a spindle mechanism achieves the necessary precision by translating the stepwise rotations of the motor into steps of linear movement. The system takes advantage of commercially available low friction parts such as ball bearings, ball bushings and axles with hardened surfaces. The related electronic control unit is designed around the most recent integrated circuitry which is both sophisticated and economical. Though the described sy…

A frequency compensation algorithm of four-wheel coherence random road

2013

Published version of an article in the journal: Mathematical Problems in Engineering. Also available from the publisher at: http://dx.doi.org/10.1155/2013/986584 Open access The road surface roughness is the main source of kinematic excitation of a moving vehicle, which has an important influence on vehicle performance. In recent decades, random road models have been widely studied, and a four-wheel random road time domain model is usually generated based on the correlation of the four-wheel input, in which a coherence function is used to describe the coherence of the road input between the left and right wheels usually. However, during our research, there are some conditions that show that…

A nonlinear dynamical approach to the path correction of multi-steering articulated vehicles

2020

When designing articulated tractor-trailer systems, engineers should take care to contrast some undesired phenomena associated with the lateral dynamics: the path off-tracking, namely the trajector...

Päijänteen rantoja

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Numerical study for a new methodology of flaws detection in train axles

2013

Train loads and travel speeds have increased over time, requiring more efficient non-destructive inspection methods. Railway axles are critical elements; despite being designed to last more than 20 years several cases of premature failure have been recorded. Train axles are inspected regularly, but the limits associated to the traditional inspection technologies create a growing interest towards new solutions. Here a novel non-destructive inspection method of in-service axles based on non-contact data collection is presented. The propagation of surface waves, generated by a thermo-elastic laser source, is investigated using a finite element method based on dynamic explicit integration. Coup…