Search results for "Alcohol"

showing 10 items of 1798 documents

Thoughts on What Chemists Can Contribute to Fighting SARS-CoV-2 - A Short Note on Hand Sanitizers, Drug Candidates and Outreach.

2020

Abstract The SARS‐CoV‐2 outbreak causing the respiratory disease COVID‐19 has left many chemists in academia without an obvious option to contribute to fighting the pandemic. Some of our recent experiences indicate that there are ways to overcome this dilemma. A three‐pronged approach is proposed.

DNA Replication2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Hand SanitizersPneumonia Viral010402 general chemistry01 natural sciencesAntiviral AgentsCatalysisalcohols2-PropanolBetacoronavirusViewpointantiviralsPolitical sciencePandemicHumansPandemicshealth care economics and organizationsEthanol010405 organic chemistrybusiness.industrySARS-CoV-2pandemicCOVID-19General MedicineGeneral ChemistryDNA-Directed RNA PolymerasesPublic relations0104 chemical sciencesDilemmaOutreachViewpointsChemists in the CommunitybusinessCoronavirus InfectionsdisinfectantsCoronavirus InfectionsAngewandte Chemie (International ed. in English)
researchProduct

Functional and genomic diversity of methylotrophic Rhodocyclaceae: description of Methyloversatilis discipulorum sp. nov.

2015

Three strains of methylotrophic Rhodocyclaceae (FAM1T, RZ18-153 and RZ94) isolated from Lake Washington sediment samples were characterized. Based on phylogenetic analysis of 16S rRNA gene sequences the strains should be assigned to the genus Methyloversatilis. Similarly to other members of the family, the strains show broad metabolic capabilities and are able to utilize a number of organic acids, alcohols and aromatic compounds in addition to methanol and methylamine. The main fatty acids were 16:1ω7c (49–59 %) and 16:0 (32–29 %). Genomes of all isolates were sequenced, assembled and annotated in collaboration with the DOE Joint Genome Institute (JGI). Genome comparison revealed that the s…

DNA BacterialWashingtonGeologic SedimentsRhodocyclaceaeSequence analysisMolecular Sequence Datalake sedimentsRhodocyclaceaeMicrobiologyPhylogeneticsRNA Ribosomal 16SMalate synthasePhylogenyEcology Evolution Behavior and SystematicsGeneticsbiologyMethanol dehydrogenaseta1184phylogenetic analysista1183Fatty AcidsGenomicsSequence Analysis DNAGeneral MedicineIsocitrate lyaseRibosomal RNA16S ribosomal RNAbiology.organism_classificationBacterial Typing TechniquesAlcohol OxidoreductasesLakesBiochemistrybiology.proteinmetabolismGenome BacterialInternational Journal of Systematic and Evolutionary Microbiology
researchProduct

A real-time PCR assay for detection and quantification of 2-branched (1,3)-β-D–glucan producing lactic acid bacteria in cider

2010

28 p.-1 fig.-4 tab.

DNA Bacterialbeta-GlucansFood spoilageMicrobiologyMelting curve analysisMicrobiologyPolysaccharidesLactobacillus(13)(12)--D-glucanLactic acid bacteriaFood sciencePediococcusOenococcusOenococcus oeniDNA PrimersbiologyBacteriaSpoilageReverse Transcriptase Polymerase Chain ReactionAlcoholic BeveragesGeneral MedicineAmpliconbiology.organism_classificationBacterial Typing TechniquesLactobacillusCidersGenes BacterialGlucosyltransferasesFood MicrobiologyPediococcusProteoglycansOenococcusBacteriaFood ScienceReal-time PCR
researchProduct

Novel σ1 antagonists designed for tumor therapy: Structure – activity relationships of aminoethyl substituted cyclohexanes

2021

Abstract Depending on the substitution pattern and stereochemistry, 1,3-dioxanes 1 with an aminoethyl moiety in 4-position represent potent σ1 receptor antagonists. In order to increase the stability, a cyclohexane ring first replaced the acetalic 1, 3-dioxane ring of 1. A large set of aminoethyl substituted cyclohexane derivatives was prepared in a six-step synthesis. All enantiomers and diastereomers were separated by chiral HPLC at the stage of the primary alcohol 7, and their absolute configuration was determined by CD spectroscopy. Neither the relative nor the absolute configuration had a large impact on the σ1 affinity. The highest σ1 affinity was found for cis-configured benzylamines…

DU145 tumor cellsCachannelPrimary alcohol01 natural sciencesAminoethylcyclohexanes; Antagonistic activity; Biotransformation; Ca; 2+; influx assay; Calculated free energy of binding; CD spectroscopy; Chiral HPLC; DU145 tumor cells; Inhibition of human prostate tumor cell growth; Lipophilicity; Molecular dynamics simulations; Molecular interactions; per-residue binding free energy; Selectivity; Stereochemistry; Structure affinity relationships; Voltage gated Ca; 2+; channel; σ receptors; σ; 1; receptor affinityInhibition of human prostate tumor cell growthStereochemistryDrug DiscoveryMoietySelectivityBiotransformationσ receptor0303 health sciencesChemistryAminoethylcyclohexanesCD spectroscopyAbsolute configurationAminoethylcyclohexaneMolecular interactionGeneral MedicineAntagonistic activityper-residue binding free energyreceptor affinityLipophilicityVoltage gated CaStereochemistry12+Calculated free energy of bindingRetinal ganglion03 medical and health sciencesσMolecular dynamics simulationChiral HPLCLipophilicityMolecular interactionsStructure affinity relationship030304 developmental biologyPharmacologyDU145 tumor cellinflux assayMolecular dynamics simulations010405 organic chemistryOrganic ChemistryDiastereomer0104 chemical sciencesChiral column chromatographyσ receptorsStructure affinity relationshipsEnantiomerEuropean Journal of Medicinal Chemistry
researchProduct

Impact of structural features of odorant molecules on their retention/release behaviours in dairy and pectin gels

2014

International audience; Reducing of fat content in food requires a reformulation that may cause a different perception of aroma. Maintaining an adequate level of acceptability of these reformulated products for consumers requires a better understanding of the mechanisms that control the retention of odorant molecules in food matrices. Although pectins are commonly employed as thickeners, their effect on the retention of odorant molecules in nonhomogeneous products has been examined more frequently than their effect on the retention of odorant molecules in simple gels models.The purpose of this study was to explore and compare the respective effects of pectin in simple model systems. The rel…

Dairy gelschemistry.chemical_classificationANOVAfood.ingredientOdorant moleculesPectinbiologyDouble bondFat contentAlcoholPrimary alcoholPectin gelsbiology.organism_classificationRetention/releasechemistry.chemical_compoundPairwise testsfoodchemistryNerolMoleculeOrganic chemistry[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology[SDV.AEN]Life Sciences [q-bio]/Food and NutritionAromaFood ScienceFood Research International
researchProduct

Isobaric vapor–liquid equilibria for the system 1-pentanol–1-propanol–water at 101.3 kPa

2001

Consistent vapor–liquid equilibrium data for the ternary system 1-pentanol–1-propanol–water is reported at 101.3 kPa at temperatures in the range of 362–393 K. The VLE data were satisfactorily correlated with UNIQUAC model. The authors wish to thank the Generalitat Valenciana (Spain) for the financial help of the Project GV-3174/95 and DGES for the financial aids of the Project PB96-0338.

DataUNIQUACTernary numeral systemAqueous solutionGeneral Chemical EngineeringUNIQUACGeneral Physics and AstronomyThermodynamicsWaterVapor–liquid equilibriaGroup contribution methodCorrelation1-propanolPropanolIngeniería Químicachemistry.chemical_compound1-Propanolchemistry1-PentanolAlcoholsIsobaric process1-pentanolPhysical and Theoretical Chemistry
researchProduct

Predisposición genética en el consumo de alcohol: el caso de la Alcohol Deshidrogenasa 1C

2007

Introduccion: El consumo de alcohol se presenta frecuentemente asociado a determinados delitos, siendo en unas ocasiones atenuante o eximente, y en otras una infraccion penal per se. Se han identificado numerosos factores geneticos y ambientales que predisponen al consumo de alcohol. Nuestro objetivo ha sido estudiar la prevalencia del polimorfismo Ile349Val en la alcohol deshidrogenasa 1C que da lugar a la isoforma gamma 2 (metabolizador lento), y estudiar su asociacion con el consumo de alcohol asi como reflexionar sobre la dimension de la implicacion de estas variantes geneticas en la Medicina Legal. Material y Metodos: Se ha genotipado el polimorfismo Ile 349Val en 869 individuos proced…

DelitoGenEtanolBebidas AlcohólicasAlcohol DeshidrogenasaPathology and Forensic MedicineCuadernos de Medicina Forense
researchProduct

Flow injection near-infrared determination of ethanol in chloroform

1995

A simple and direct flow injection (FIA) procedure has been developed for the determination of the stabilizing agent ethanol in chloroform samples. The procedure is based on the use of the absorbance band of ethanol in the near-infrared (NIR) region at 2272 nm, measured in front of a reference sample of chloroform stabilized with amylene. The method developed provides a limit of detection of 0.0045% (v/v) and a dynamic range until 10% (v/v) with a typical variation coefficient of 0.4% for six independent analysis of a real sample containing approximately 1% (v/v) of ethanol. The sample injection frequency allowed by the method is 78 h−1.

Detection limitAbsorbancechemistry.chemical_compoundEthanolChloroformchemistryReference sampleNear-infrared spectroscopyAnalytical chemistryAlcoholBiochemistryDirect flowFresenius' Journal of Analytical Chemistry
researchProduct

Determination of hydroxytyrosol and tyrosol by liquid chromatography for the quality control of cosmetic products based on olive extracts

2014

An analytical method for the simultaneous determination of hydroxytyrosol and tyrosol in different types of olive extract raw materials and cosmetic cream samples has been developed. The determination was performed by liquid chromatography with UV spectrophotometric detection. Different chromatographic parameters, such as mobile phase pH and composition, oven temperature and different sample preparation variables were studied. The best chromatographic separation was obtained under the following conditions: C18 column set at 35°C and isocratic elution of a mixture ethanol: 1% acetic acid solution at pH 5 (5:95, v/v) as mobile phase pumped at 1 mL min(-1). The detection wavelength was set at …

Detection limitAnalyteChromatographyIsocratic elutionPlant ExtractsClinical BiochemistryPharmaceutical ScienceCosmeticsRepeatabilityPhenylethyl AlcoholRaw materialAnalytical ChemistryTyrosolchemistry.chemical_compoundchemistryLimit of DetectionOleaDrug DiscoveryHydroxytyrosolSpectrophotometry UltravioletSample preparationSpectroscopyChromatography LiquidJournal of Pharmaceutical and Biomedical Analysis
researchProduct

Determination of alternative preservatives in cosmetic products by chromophoric derivatization followed by vortex-assisted liquid-liquid semimicroext…

2016

An analytical method for the simultaneous determination of phenethyl alcohol, methylpropanediol, phenylpropanol, caprylyl glycol, and ethylhexylglycerin, which are used as alternative preservatives in cosmetic products, has been developed. The method is based on liquid chromatography with UV spectrophotometric detection after chromophoric derivatization with benzoyl chloride and vortex-assisted liquid-liquid semimicroextraction. Different chromatographic parameters, derivatization conditions, and sample preparation variables were studied. Under optimized conditions, the limits of detection values for the analytes ranged from 0.02 to 0.06µgmL(-1). The method was validated with good recovery …

Detection limitAnalytePreservativeChromatographymedia_common.quotation_subject010401 analytical chemistryPreservatives Pharmaceutical02 engineering and technologyCosmeticsPhenylethyl Alcohol021001 nanoscience & nanotechnology01 natural sciencesCosmetics0104 chemical sciencesAnalytical Chemistrychemistry.chemical_compoundBenzoyl chloridechemistryPhenethyl alcoholSample preparation0210 nano-technologyDerivatizationmedia_commonChromatography LiquidTalanta
researchProduct