Search results for "Alcohols"
showing 10 items of 150 documents
New antitumoral acetogenin ‘Guanacone type’ derivatives: Isolation and bioactivity. Molecular dynamics simulation of diacetyl-guanacone
2007
We describe herein the isolation and semisynthesis of four acetogenin derivatives (1-4) as well as their ability to inhibit the mitochondrial respiratory chain and several tumor cell lines. In addition, four nanoseconds (ns) of MD simulation of compound 4, in a fully hydrated POPC bilayer, is reported.
Active surfaces engineered by immobilizing protein-polymer nanoreactors for selectively detecting sugar alcohols.
2016
We introduce active surfaces generated by immobilizing protein-polymer nanoreactors on a solid support for sensitive sugar alcohols detection. First, such selective nanoreactors were engineered in solution by simultaneous encapsulation of specific enzymes in copolymer polymersomes, and insertion of membrane proteins for selective conduct of sugar alcohols. Despite the artificial surroundings, and the thickness of the copolymer membrane, functionality of reconstituted Escherichia coli glycerol facilitator (GlpF) was preserved, and allowed selective diffusion of sugar alcohols to the inner cavity of the polymersome, where encapsulated ribitol dehydrogenase (RDH) enzymes served as biosensing e…
Syntheses and structural study of bile acid amidoalcohols.
2008
Preparation, structural and thermoanalytical characterization of fourteen N-hydroxyalkyl 5beta-cholan-24-amides have been performed in this study. The utilized techniques include liquid state and CP-MAS 13C NMR spectroscopy, thermogravimetry, differential scanning calorimetry, and also powder and single crystal X-ray crystallography. The results were discussed and compared to each other and also to previous findings on similar compounds. One pure hydrate form was obtained. Six new single crystal structures were determined, including one hydrated chloroform solvate. Decomposition temperatures were found to correlate with the side chain length, and the number of the hydroxyl groups. The spati…
Ligand structures of synthetic deoxa-pyranosylamines with raucaffricine and strictosidine glucosidases provide structural insights into their binding…
2014
Insight into the structure and inhibition mechanism of O-β-d-glucosidases by deoxa-pyranosylamine type inhibitors is provided by X-ray analysis of complexes between raucaffricine and strictosidine glucosidases and N-(cyclohexylmethyl)-, N-(cyclohexyl)- and N-(bromobenzyl)-β-d-gluco-1,5-deoxa-pyranosylamine. All inhibitors anchored exclusively in the catalytic active site by competition with appropriate enzyme substrates. Thus facilitated prospective elucidation of the binding networks with residues located at <3.9 A distance will enable the development of potent inhibitors suitable for the production of valuable alkaloid glucosides, raucaffricine and strictosidine, by means of synthesis in …
Multifaceted Palladium Catalysts Towards the Tandem Diboration-Arylation Reactions of Alkenes
2008
Novel Pd(2) (6+) compounds have been synthesized in high yield. These compounds and their Pd(2) (4+) counterparts as synthetic precursors mediate the diboration of vinylarenes and aliphatic 1-alkenes, and under mild and basic reaction conditions they produce a variety of 1,2-diboronate esters with excellent conversions and chemoselectivities. The presence of bis(catecholato)diboron (B(2)cat(2)) favours the reduction of Pd(III) to Pd(II), while the catalytic precursor of Pd(II) is transformed into Pd(0)-nanoparticles. An "in situ" catalytic tandem reaction has been designed to transform the diboronate intermediates into the monoarylated product, which after oxidative workup, provides the car…
The Antigerminative Activity of Twenty-Seven Monoterpenes
2010
Made available in DSpace on 2013-08-28T14:11:28Z (GMT). No. of bitstreams: 1 WOS000282221100055.pdf: 183420 bytes, checksum: 31d5a1904cd2424113da7989e2e65f14 (MD5) Made available in DSpace on 2013-09-30T18:36:29Z (GMT). No. of bitstreams: 2 WOS000282221100055.pdf: 183420 bytes, checksum: 31d5a1904cd2424113da7989e2e65f14 (MD5) WOS000282221100055.pdf.txt: 26866 bytes, checksum: 653cedb4f682463998ef7f37cae8dd63 (MD5) Previous issue date: 2010-09-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:48:46Z No. of bitstreams: 2 WOS000282221100055.pdf: 183420 bytes, checksum: 31d5a1904cd2424113da7989e2e65f14 (MD5) WOS000282221100055.pdf.txt: 26866 bytes, ch…
Ursolic acid from the Chinese herb Danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells
2007
Danshen, the dried root of Salvia miltiorrhiza Bunge (Lamiaceae), is one of the most commonly used traditional Chinese medicines for cardiovascular indications. In EA.hy 926 cells, a cell line derived from human umbilical vein endothelial cells (HUVEC), an aqueous extract of danshen, and also a methanol extract of the plant, increased eNOS promoter activity, eNOS mRNA and protein expression, as well as endothelial NO production. A dichloromethane extract, in contrast, did not change eNOS gene expression. Thus, the active danshen constituent(s) responsible for eNOS upregulation is (are) hydrophilic and/or alcohol-soluble. One such compound is ursolic acid that significantly increased eNOS ex…
A catalytic highly enantioselective direct synthesis of 2-bromo-2-nitroalkan-1-ols through a Henry reaction.
2008
Highly enantiomerically enriched 2-bromo-2-nitroalkan-1-ols are prepared by direct condensation of aliphatic and aromatic aldehydes with bromonitromethane in the presence of a catalytic amount of copper(II) acetate and a C1-symmetric camphorderived amino pyridine ligand. Blay Llinares, Gonzalo, Gonzalo.Blay@uv.es ; Hernandez Olmos, Victor, Victor.Hernandez@uv.es ; Pedro Llinares, Jose Ramon, Jose.R.Pedro@uv.es
Chiral Oxazolidine Complexes Derived from Phenolic Schiff Bases
2020
Schiff bases derived from pyridyl- or salicyl-aldehydes and aminoalcohols can evolve to heterocyclic oxazolidines, which in the presence of cations allow the formation of uncommon coordination compounds. In this work, we report new NiII and mixed valence MnII/ MnIV complexes derived from pyridyl oxazolidines and the unprecedented characterization of enantiomerically pure oxazolidines derived from the condensation of o-vanillin with phenylglycinol in the presence of NiII cations. The different reactivity of the pyridinic or phenolic Schiff bases has been compared, and the new systems have been structurally, optically, and magnetically characterized.
Computational Investigation of Alkynols and Alkyndiols Hydrogenation on a Palladium Cluster
2013
The reaction path leading to the partial and total reduction of alkynols and alkyndiols with general formula R–CH2–C≡C–CH(OH)–R′ and R–CH(OH)–C≡C–CH(OH)–R′ (R, R′ = H, CH3) on a D3h symmetry Pd9 cl...