Search results for "Aldimine"
showing 10 items of 34 documents
CCDC 628155: Experimental Crystal Structure Determination
2008
Related Article: C.Faulmann, S.Dorbes, S.Lampert, K.Jacob, B.G.de Bonneval, G.Molnar, A.Bousseksou, J.A.Real, L.Valade|2007|Inorg.Chim.Acta|360|3870|doi:10.1016/j.ica.2007.03.022
CCDC 120320: Experimental Crystal Structure Determination
1997
Related Article: J.-A.Perez-Adelmar, H.Abraham, C.Sanchez, K.Rissanen, P.Prados, J.de Mendoza|1996|Angew.Chem.,Int.Ed.|35|1009|doi:10.1002/anie.199610091
ChemInform Abstract: Highly Enantioselective Zinc/Binol-Catalyzed Alkynylation of N-Sulfonyl Aldimines.
2008
Enantioselective addition of Et2Zn to seven‐membered cyclic imines catalyzed by a (R)-VAPOL-Zn(II) complex
2017
Various substituted dibenzo[b,f][1,4]oxazepines underwent an enantioselective alkylation with Et2Zn catalyzed by a (R)-VAPOL-Zn(II) complex. The corresponding chiral 11-ethyl-10,11-dihydrodibenzo[b,f][1,4]oxazepine derivatives were obtained with good yields and moderate enantioselectivities. This represents the first example of enantioselective addition of Et2Zn to cyclic aldimines.
ChemInform Abstract: Enantioselective Addition of Terminal Alkynes to N-(Diphenylphosphinoyl)imines Catalyzed by Zn-BINOL Complexes.
2012
Abstract Chiral nonracemic N-(diphenylphosphinoyl)-protected propargylic amines have been prepared by addition of terminal alkynes to N-(diphenylphosphinoyl)aldimines in the presence of dimethylzinc and 3,3′-dibromo-BINOL as catalyst. The reaction works with a variety of aromatic and heteroaromatic aldimines and with different alkynes, providing the expected products in generally good yields and enantiomeric excesses (up to 96%).
Stereoselective Synthesis of 2-Substituted Pyrrolidines
2000
Using O-pivaloyl protected D-galactopyranosylamine and D-arabinopyranosylamine, (S) or (R) configured α-substituted homoallylamines are synthesized with high diastereoselectivity by reaction of the corresponding aldimines with allyltributylstannane. Electrophile-induced endo-trig-cyclization of these N-glycosylhomoallylamines gave the 2-substituted pyrrolidines of high diastereomeric purity.
Synthesis of Highly Substituted Unsymmetrical 1,2-Diamines, 1,2-Diimines, Imidazolium Salts and Imidazolylidenes by Aldimine Cross-Coupling
2007
α-Aminonitriles derived from aromatic aldehydes and primary amines can be deprotonated quantitatively without the use of protecting groups. The 1,2-addition of the resulting stabilized α-aminocarbanions to imines yields α-aminoimines and the tautomeric enediamines. These unstable compounds can directly be oxidized to 1,2-diimines or reduced to 1,2-diamines in a one-pot reaction. 1,2-Diamines can be obtained in high diastereoselectivity by reduction of the 1,2-diimines. In this case, the relative configuration of the products can be chosen depending on the reduction conditions. Cyclization of the unsymmetrical diimines with halomethyl ethers or esters leads to 1,3,4,5-tetrasubstituted imidaz…
Reactions of α-diimino ligands with the chloro-bridged dimer [RhCl(COD)]2(COD=1,5-cyclooctadiene)
1988
Abstract The reactions of α-diimino ligands N - N ′ [ N - N ′= 2,2′-bipyridine (bipy), C 5 H 4 N2CHNR (R= C 6 H 4 OMe- p , PyCa), RNCHCHNR (R=C 6 H 4 - OMe- p , DAB)] with [RhCl(COD)] 2 give rise to stoichiometry, solvent, ligand, and temperature dependent equilibria. In general, the 1/1 ligand/dimer reaction yields the ionic product [Rh(COD)( N - N ′)] [RhCl 2 (COD)], at room temperature. For N - N ′=DAB, the ionic form is in equilibrium with the binuclear compound [{RhCl(COD)} (μ-DAB){RhCl(COD)}] (containing a σ σ,'- N , N ′ bridging α-diimine), which becomes the predominant species at low temperatures. In [Rh(COD)( N - N ′)] [RhCl 2 (COD)], a fast exchange of the Rh(COD) unit betwe…
Palladium-Catalyzed C—C Coupling Reactions in the Enantioselective Synthesis of 2,4-Disubstituted 4,5-Dehydropiperidines Using Galactosylamine as a S…
2005
Abstract Stereoselective synthesis of enantiomerically pure 2,4-disubstituted piperidine derivatives, which are considered interesting pharmacophoric structures, was achieved starting with a tandem Mannich–Michael reaction sequence on O -pivaloylated N -galactosyl aldimines. Subsequent conversion of the thus formed 2-substituted dehydropiperidinones into the corresponding enol triflates was carried out by conjugate hydride addition and trapping the enolate with N , N -bis(trifluoromethanesulfonyl)aniline. Their Suzuki–Miyaura coupling with aryl and heteroaryl boronic acids was performed under conditions compatible with the carbohydrate structure, in particular, with the sensitive N -glycosi…
Organocatalyticanti-Selective Mannich Reactions with Fluorinated Aldimines: Synthesis ofanti-γ-Fluoroalkyl-γ-amino Alcohols
2009
The asymmetric Mannich reaction between fluoroalkyl aldimines and aldehydes catalyzed by α,α-diphenylprolinol trimethylsilyl ether is reported. The corresponding Mannich adducts were reduced in situ to afford anti-β-alkyl-γ-fluoroalkyl-γ-amino alcohols in moderate yields and with very high diastereo- and enantioselectivities. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)