Search results for "Alter"
showing 10 items of 2368 documents
Tilted implants for the restoration of posterior mandibles with horizontal atrophy: An alternative treatment
2013
Purpose Horizontal atrophy in the posterior mandible presents serious limitations on conventional implant placement. The purpose of this study was to evaluate the use of tilted implants angled in a buccolingual direction for restoring atrophic posterior mandibular sectors. Materials and Methods A cohort study was performed of 25 patients who had partial prostheses supported by more than 1 implant (≥1 tilted and 1 axial implant) to restore molar areas in the mandible. When the bone thickness was at least 5 mm, axial implants were placed; when the alveolar ridge was narrower, the implant was placed with tilted angulation. The beds for these tilted implants were prepared using a lingual approa…
Caspase-mediated apoptosis in sponges: cloning and function of the phylogenetic oldest apoptotic proteases from Metazoa
2003
AbstractSponges (phylum Porifera) represent the phylogenetically oldest metazoan phylum. These animals have complex cell adhesion and powerful immune systems which allow the formation of a distinct body plan. Consequently, an apoptotic machinery has to be predicted that allows sponges to eliminate unwanted cells accumulating during development. With the marine sponge Geodia cydonium, it is shown that allografts of these animals undergo apoptosis as demonstrated by apoptotic DNA fragmentation. Extracts from allografts contain an enzymic activity characteristic for caspases; as substrate to determine the cleavage activity, Ac-DEVD-AMC was applied. cDNAs encoding predicted caspase-3-related pr…
The nuclear autoantigen La/SS-associated antigen B: One gene, three functional mRNAs
1997
Transcription of the gene encoding for the nuclear autoantigen La resulted in three mRNA forms. A promoter switching combined with an alternative splicing pathway replaced exon 1 with either exon 1´ or exon 1´´. The exon 1´´ donor splice site was located 4 nts downstream of the exon 1´ donor splice site. All three La mRNA forms were expressed in all the tissues analysed including peripheral blood lymphocytes, liver, fetal spleen, cultured primary endothelial cells, and mouse LTA cell lines permanently transfected with the human La gene. Both the exons 1´ and 1´´ had unusual structures. They contained GC-rich regions and an oligo(U)-tail of 23 uridine residues. Moreover, they encoded for thr…
Conserved Structure and Promoter Sequence Similarity in the Mouse and Human Genes Encoding the Zinc Finger Factor BERF-1/BFCOL1/ZBP-89
2001
Abstract We have characterized the genomic structure of the mouse Zfp148 gene encoding Beta-Enolase Repressor Factor-1 (BERF-1), a Kruppel-like zinc finger protein involved in the transcriptional regulation of several genes, which is also termed ZBP-89, BFCOL1. The cloned Zfp148 gene spans 110 kb of genomic DNA encompassing the 5′-end region, 9 exons, 8 introns, and the 3′-untranslated region. The promoter region displays the typical features of a housekeeping gene: a high G+C content and the absence of canonical TATA and CAAT boxes consistent with the multiple transcription initiation sites determined by primary extension analysis. Computer-assisted search in the human genome database allo…
Sponges (Porifera) Molecular Model Systems to Study Cellular Differentiation in Metazoa
1998
Evolution is a gradual process whereby primarily new genes are formed either by gene duplication (Ohno 1970) or exon shuffling (Gilbert 1978). New proteins can also be produced by overlapping genes, alternative splicing or gene sharing (Li and Graur 1991). These facts imply that (1) proteins found in a given phylum contain elements or modules which are present already in ancestral protein(s) of members of phylogenetically older phyla and (2) that new combinations of such modules create proteins that possess new functions.
New Biologically Active Triterpene-Saponins fromRandia dumetorum
1990
Two new triterpene-saponins, 3-O-[O-beta-D-glucopyranosyl-(1----4)-O-beta-D-glucopyranosyl-(1----3)-( beta- D-glucuronopyranosyl)]oleanolic acid (1), 3-O-[O-beta-D-glucopyranosyl-(1----6)-O-beta-D-glucopyranosyl- (1----3)-(beta-D-glucuronopyranosyl)]oleanolic acid (2) together with five known saponins (3-7) were isolated from the methanolic extract of the fruits of Randia dumetorum (Retz) Lam. (Rubiaceae). Their structures were established on the basis of chemical and spectral data. The compounds 1, 3, 4, 5 were found to enhance significantly the proliferation of human lymphocytes in vitro. The crude saponin fraction showed haemolytic, molluscicidal, and immunostimulating activities.
Animal Models of Stress - Current Knowledge and Potential Directions
2021
Finding new therapies and new antidepressant agents is of high clinical priority given that many cases of depressive disorder do not respond to conventional monoaminergic antidepressants such as selective serotonin reuptake inhibitors, tricyclic antidepressants, and monoamine oxidase inhibitors The authors demonstrated that electroacupuncture and fluoxetine, a second-generation antidepressant categorized as a selective serotonin reuptake inhibitor (Perez-Caballero et al , 2014), regulate the expression of key proteins in the calmodulin kinase (CAMK) signaling pathway, which are related to depression in the hippocampi of rats (Takemoto-Kimura et al , 2017;Xie et al , 2019) In a paper on “Sho…
New Alkaloids of the Sarpagine Group from Rauvolfia serpentina Hairy Root Culture
2002
Three new monoterpenoid indole alkaloids, 19(S),20(R)-dihydroperaksine (1), 19(S),20(R)-dihydroperaksine-17-al (2), and 10-hydroxy-19(S),20(R)-dihydroperaksine (3), along with 16 known alkaloids 4-19 were isolated from hairy root culture of Rauvolfia serpentina, and their structures were elucidated by 1D and 2D NMR analyses. Taking into account the stereochemistry of the new alkaloids and results of preliminary enzymatical studies, the putative biosynthetical relationships between the novel alkaloids are discussed.
Fundamentos antropológicos en las relaciones interpersonales y de reciprocidad en el pensamiento de Emmanuel Mounier
2013
Uno puede preguntarse si el pensamiento de Emmanuel Mounier es actual o tiene capacidad de influir en el mundo contemporáneo. Sólo basta con echar un vistazo rápido a nuestra realidad actual y aquella que vivió nuestro autor para observar, sobre todo después de los acontecimientos del 11 de septiembre de 2001, las guerras en Irak y Afganistán, las distintas y variadas guerras menores a lo largo del mundo, tras el colapso las bolsas de valores y los mercados en 2008 y 2009, que el mundo nunca había estado tan cerca de una crisis de civilización como aquella crisis de económica del '29 que engendró a la Segunda Guerra Mundial y que parece poner en peligro la propia supervivencia de la cultura…
Análisis de los factores que influyen en el aprendizaje del uso de los instrumentos endodónticos
2017
-Objetivo. El objetivo general es analizar algunos de los factores que pueden influir en el proceso de enseñanza/aprendizaje del uso de nuevos instrumentos endodónticos de lima única y movimiento alternante, evaluando el nivel de aprendizaje progresivo de los operadores, así como la influencia de la curvatura del conducto en el aprendizaje, estableciendo para ello el número de bloques que debe instrumentar un mismo operador hasta lograr un nivel de aprendizaje tras el cual no se observe mejora en su rendimiento. -Metodología. Se instrumentaron conductos simulados en bloques de resina, de curvatura simple y doble curvatura, por operadores con experiencia y sin experiencia, utilizando la lima…