Search results for "Anatomia"

Isolation and characterization of circulating exosomes from blood in brain tumors

Exosomes (EXs) are crucial in mediating intercellular communication in physiological and pathological conditions. Accordingly, tumor-secreted EXs play an important role in regulating tumor malignancy. Tumor-derived exosomes contain proteins, mRNAs, and miRNAs, which can be delivered between different types of cells and even transferred to distant locations to influence the biological activities of tumors, such as proliferation, invasion and metastasis (1). Clinically, tumor-derived EXs may represent a target for therapeutic intervention and for the development of early diagnostic biomarkers (2). In our laboratory, we have focused on the isolation, morphological analyses, determination of par…

Hsp60 levels and mitochondrial biogenesis in skeletal muscle after endurance training

Anti-cancer effects of Pleurotus eryngii var. eryngii: an in vitro and in vivo models focusing on Heat Shock Proteins

2017

Heat shock proteins (Hsps) are highly expressed in a variety of cancer cells and are essential to their survival contributing to tumor cell propagation, metastasis, and protection against apoptosis]. Cancer is a leading cause of death worldwide. The current anti-cancer drugs available in market are not target specific and pose several side-effects and complications in clinical management of various forms of cancer, which highlights the urgent need for novel effective and less-toxic therapeutic approaches. Medicinal mushrooms have emerged as wonderful source of nutraceuticals, anti-oxidants, anticancer, prebiotic, anti-inflammatory, cardiovascular, anti-microbial, and anti-diabetic. The ongo…

Evaluation of neuropeptide Y expression during acetaldehyde withdrawal in rats. Focus on hippocampus and nucleus accumbens

2012

Stress-related neuropeptides are involved in setting up alcohol addiction. Ethanol is able to acutely induce CRH and ACTH release, while cronically a dampered response of the hypothalamus -pituitary- adrenal (HPA) axis has been observed. Also neuropeptide Y (NPY) has been shown to modulate ethanol consumption, and its central expression seems inversely correlated to ethanol intake. Recent in vivo and in vitro evidence have highlighted the key role of acetaldehyde (ACD), ethanol first metabolite, as a mediator of the central effects of ethanol, even as modulator of the neuropeptidergic transmission in the rat brain. The aim of this study was to investigate NPY immunoreactivity following a 4-…

Small airways in sedentary and endurance-trained dystrophic (mdx) mice.

2015

The effects of mild endurance exercise training on the small airways in mdx mice are unknown. We compared epithelial thickness and turnover, apoptosis, and stress marker expression in small airways of mdx mice and wild-type (WT) controls, at rest and during exercise training. Mdx and WT mice were randomly assigned to sedentary (mdx-S, n=17; WT-S, n=19) or trained (mdx- EX, n=14; WT-EX, n=16) groups. Low-intensity endurance training (running on a wheel) was done 5 d/wk for 6 wk at progressively increasing speed (rpm from 16 to 24) and time (15 min to 1 h). Lungs were processed for light microscopy and periodic acid Schiff (PAS) staining. Hsp60 and PCNA were quantified by immunohistochemistry…

Endurance training damages small airway epithelium in mice.

2005

Analisi di biomarcatori urinari e tissutali coinvolti nei meccanismi pro- o anti-fibrotici in pazienti con stenosi del giunto pielo-ureterale unilate…

2016

Stenosi del giunto pielo-ureterale, biomarcatori urinari, fibrosi, funzione renale, matrice extracellulare.

Space medicine: use of ex vivo human respiratory mucosa in the survey of the effects of microgravity on the respiratory system

2019

In the near future, the length and scope of space travel is set to increase significantly. The number of individuals who will have access to extra-terrestrial travels is also increasing. In view of the growing international interest towards manned long-term space exploration, possible effects of exposure to microgravity conditions affecting the respiratory system are subject of interest by major space agencies (NASA and ESA primarily). Our team has developed an advanced 3d tissue model of the human bronchial mucosa within a wide research project involving several universities and space agencies at international level. The model will be used to study the structural/functional alterations of …

EFFECTS OF CONIUGATED LINOLEIC ACID ON TESTOSTERONE SYNTHESIS.

2011

Role of Smads in respiratory disease pathogenesis

2008

Transforming Growth Factor beta (TGFβ) cytokine plays an important role in normal pulmonary morphogenesis and function as well as in the pathogenesis of lung diseases. The principal signaling pathway downstream to activate TGFβ is the Smad pathway. Even though many studies have focused on Smads’ structural features and pathway, less is known about the possible relationship between protein and mRNA expression of Smads and lung diseases. This review will focus on Smads and sum up what is know about their role in some respiratory diseases: COPD,asthma end fibrosis