Search results for "Anciano"

showing 10 items of 111 documents

CLOCK gene variation is associated with incidence of type‑2 diabetes and cardiovascular diseases in type‑2 diabetic subjects: dietary modulation in t…

2016

Background: Circadian rhythms regulate key biological processes influencing metabolic pathways. Disregulation is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). Circadian rhythms are generated by a transcriptional autoregulatory feedback loop involving core clock genes. CLOCK (circadian locomotor output cycles protein kaput), one of those core genes, is known to regulate glucose metabolism in rodent models. Cross-sectional studies in humans have reported associations between this locus and obesity, plasma glucose, hypertension and T2D prevalence, supporting its role in cardiovascular risk. However, no longitudinal study has investigated the association between CLOCK…

Male0301 basic medicineTime Factorsmodelos de riesgos proporcionalesEndocrinology Diabetes and MetabolismhumanosCLOCK ProteinsType 2 diabetesKaplan-Meier Estimatefrecuencia génica030204 cardiovascular system & hematologyDiet Mediterranean0302 clinical medicineGene FrequencyRisk Factorsevaluación de riesgosLongitudinal Studiesmediana edadOriginal InvestigationAged 80 and overancianoDiabetishomocigotodietaIncidenceresultado del tratamientoHomozygoteDiabetesdistribución de la ji al cuadradoMiddle AgedCircadian RhythmCLOCKStrokePhenotypeTreatment OutcomeCardiovascular diseasesinteracción gen-ambientediabetes mellitusfenotipoCardiology and Cardiovascular Medicineestimación de Kaplan-Meiermedicine.medical_specialtyHeterozygoteenfermedades cardiovascularesSingle-nucleotide polymorphism:Ciencias de la Salud::Nutrición y dietética [Materias Investigacion]Polymorphism Single NucleotideRisk Assessmentincidencia03 medical and health sciencesInsulin resistanceMediterranean cookingfactores de tiempo:Ciencias de la Salud::Medicina preventiva [Materias Investigacion]Diabetes mellitusInternal medicineSistema cardiovascular -- Malalties -- Aspectes genèticsMediterranean dietCuina mediterràniamedicineSNPHumansproteínas CLOCKfactores de riesgoGenetic Predisposition to DiseaseCircadian rhythmanálisis multifactorialDieta -- Mediterrània Regió de laAgedProportional Hazards ModelsChi-Square DistributionCLOCK genebusiness.industryMalalties cardiovascularspredisposición genética a la enfermedadProtective Factorsmedicine.diseaseObesityDiet030104 developmental biologyEndocrinologyritmo circadianoDiabetes Mellitus Type 2SpainMultivariate Analysisestudios longitudinalesGene-Environment Interactionbusiness:Ciencias de la Salud::Endocrinología [Materias Investigacion]heterocigoto
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Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population a…

2019

The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly participants with overweight/obesity and metabolic syndrome in the (Prevencion con Dieta Mediterranea) PREDIMED-Plus trial. Accelerometry-derived sleep duration and sleep variability were measured. Linear regression models were fitted to examine the aforementioned associations. A 1 hour/night increment in sleep duration was inversely associated with SUA concentrations ( = -0.07, p = 0.047). Further adjustment for leukocytes attenuated this association (p = 0.050). Each …

Male0301 basic medicinesueñoNefrología y urologíahumanosserum uric acid to creatinine ratioOverweightchemistry.chemical_compound0302 clinical medicineRisk FactorsMedicinemediana edadancianoeducation.field_of_studyNutrition and DieteticsMediterranean RegionCommunicationácido úricoMiddle AgedcreatininaSleep in non-human animals3. Good healthCardiovascular DiseasesCreatinineObesitatFemalemedicine.symptomlcsh:Nutrition. Foods and food supplymedicine.medical_specialtyserum uric acidPopulationenfermedades cardiovascularesDietética y nutriciónlcsh:TX341-641Cardiología03 medical and health sciences:Ciencias de la Salud::Medicina preventiva [Materias Investigacion]Internal medicineHumansfactores de riesgoObesityeducationAgedCreatininebusiness.industryActigraphymedicine.diseaseObesityactigraphy serum uric acid serum uric acid to creatinine ratio sleep durationSonUric AcidÀcid úricCross-Sectional Studies030104 developmental biologyEndocrinologychemistrySpainUric acidsleep durationMetabolic syndromebusinessSleepUric acidBiomarkers030217 neurology & neurosurgeryestudios transversalesFood Scienceactigraphy
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Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries

2018

Background: To better understand the epidemiology and patterns of tracheostomy practice for patients with acute respiratory distress syndrome (ARDS), we investigated the current usage of tracheostomy in patients with ARDS recruited into the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG-SAFE) study. Methods: This is a secondary analysis of LUNG-SAFE, an international, multicenter, prospective cohort study of patients receiving invasive or noninvasive ventilation in 50 countries spanning 5 continents. The study was carried out over 4 weeks consecutively in the winter of 2014, and 459 ICUs participated. We evaluated the clinical characteris…

MaleARDSInternationality[SDV]Life Sciences [q-bio]humanoslnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]traqueostomíaCritical Care and Intensive Care MedicineSeverity of Illness IndexCohort StudiesPropensity-matched analysi0302 clinical medicineTracheostomyestudios prospectivosEpidemiologyAcute respiratory distress syndrome (ARDS)030212 general & internal medicineProspective Studiespuntuación de propensión10. No inequalityProspective cohort studyestudios de cohortesmediana edadancianoRespiratory Distress SyndromerespiraciónRespirationlcsh:Medical emergencies. Critical care. Intensive care. First aidMiddle Aged3. Good healthIntensive Care UnitsCohortArtificialCritical IllneFemaleAcute respiratory distress syndrome (ARDS); ICU; Propensity-matched analysis; Tracheostomy; Ventilation; Aged; Cohort Studies; Critical Illness; Female; Humans; Intensive Care Units; Internationality; Male; Middle Aged; Propensity Score; Prospective Studies; Respiration Artificial; Respiratory Distress Syndrome Adult; Severity of Illness Index; TracheostomyCohort studyHumanAdultmedicine.medical_specialtyCritical IllnessIntensive Care UnitSocio-culturaleunidades de cuidados intensivosenfermedad críticaPropensity-matched analysis03 medical and health sciencesAcute respiratory distress syndrome (ARDS); ICU; Propensity-matched analysis; Tracheostomy; VentilationSeverity of illnessSettore MED/41 - ANESTESIOLOGIAmedicineHumansíndice de gravedad de la enfermedadPropensity ScoreAgedbusiness.industryResearchRespiratory Distress Syndrome Adultinternacionalidadlcsh:RC86-88.9medicine.diseaseR1Respiration ArtificialVentilationProspective Studie030228 respiratory systemPropensity score matchingEmergency medicineICUObservational studyCohort Studiebusiness
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Immunocompromised patients with acute respiratory distress syndrome: Secondary analysis of the LUNG SAFE database

2018

Background: The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiog…

MaleARDSmodelos logísticosDatabases Factualmedicine.medical_treatment[SDV]Life Sciences [q-bio]humanoslnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]Kaplan-Meier EstimateCritical Care and Intensive Care MedicineAcute respiratory failureSeverity of Illness IndexCohort Studiesrandomized-trial0302 clinical medicineMechanical ventilationRisk Factorsestudios prospectivosEpidemiology80 and overicuMedicineProspective StudiesProspective cohort studyestudios de cohortesImmunodeficiencymediana edadestadísticasAged 80 and overRespiratory Distress Syndromeancianocritically-ill patientsRespirationresultado del tratamientorespiraciónStatisticslcsh:Medical emergencies. Critical care. Intensive care. First aidadultoMiddle Aged3. Good healthfailureIntensive Care UnitsTreatment OutcomeArtificialCohortprospective multicenterImmunocompromised patientsAcute respiratory failure; ARDS; Immunocompromised patients; Mechanical ventilation; Noninvasive ventilation; Critical Care and Intensive Care MedicineFemaleNoninvasive ventilationHumanestimación de Kaplan-MeierAdultmedicine.medical_specialtyLogistic ModelIntensive Care UnitSocio-culturaleunidades de cuidados intensivossurvivalStatistics NonparametricSepsisDatabases03 medical and health sciencesImmunocompromised HostInternal medicineImmunocompromised patientcancerfactores de riesgoHumansNonparametricíndice de gravedad de la enfermedadintensive-care-unitFactualAgedMechanical ventilationbusiness.industryResearchRisk FactorRespiratory Distress Syndrome Adult030208 emergency & critical care medicinelcsh:RC86-88.9medicine.diseaseRespiration ArtificialPneumoniaProspective StudieLogistic Models030228 respiratory systemmalignanciesARDShuésped inmunodeprimidoCohort StudiebusinessAcute respiratory failure; ARDS; Immunocompromised patients; Mechanical ventilation; Noninvasive ventilation; Adult; Aged; Aged 80 and over; Cohort Studies; Databases Factual; Female; Humans; Intensive Care Units; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Prospective Studies; Respiration Artificial; Respiratory Distress Syndrome Adult; Risk Factors; Severity of Illness Index; Statistics Nonparametric; Treatment Outcome; Immunocompromised Host
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Impact of frailty and atrial fibrillation in elderly patients with acute coronary syndromes

2021

Background: There is scarce information on the prognostic role of frailty and Atrial Fibrillation (AF) in elderly patients Acute Coronary Syndrome (ACS). Methods: The aim was to analyse the management of elderly patients with frailty and AF who suffered an ACS using data of the prospective multicentre LONGEVO-SCA registry. We evaluated the predictive performance of FRAIL, Charlson scores and AF status for adverse events at 6 months follow-up. Results: A total of 531 unselected patients with ACS and above 80 years old [mean age 84.4 (SD=3.6) years; 322 (60.6%) male] were enrolled, of whom 128 (24.1%) with AF and 145 (27.3%) with frailty. Mutually exclusive number of patients were as follows:…

MaleAcute coronary syndromemedicine.medical_specialtyEnfermedad cardiovascularAncianoClinical BiochemistryCharlson indexComorbidity030204 cardiovascular system & hematologyMutually exclusive eventsPatient ReadmissionSeverity of Illness IndexBiochemistry03 medical and health sciences0302 clinical medicineInternal medicineAtrial FibrillationDiabetes MellitusMyocardial RevascularizationmedicineHumansCognitive DysfunctionSinus rhythm030212 general & internal medicineAcute Coronary SyndromeMortalityAdverse effectAnciano frágilAgedProportional Hazards ModelsAged 80 and overHeart FailureFibrilación atrialFrailtybusiness.industryInsuficiencia cardíacaAtrial fibrillationMean ageGeneral Medicinemedicine.diseaseStrokeFunctional StatusCardiovascular DiseasesCardiologyFemaleFunctional statusbusinessEuropean Journal of Clinical Investigation
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The Genotype of the Donor for the (GT)n Polymorphism in the Promoter/Enhancer of FOXP3 Is Associated with the Development of Severe Acute GVHD but Do…

2015

The FOXP3 gene encodes for a protein (Foxp3) involved in the development and functional activity of regulatory T cells (CD4+/CD25+/Foxp3+), which exert regulatory and suppressive roles over the immune system. After allogeneic stem cell transplantation, regulatory T cells are known to mitigate graft versus host disease while probably maintaining a graft versus leukemia effect. Short alleles (<=(GT)(15)) for the (GT)(n) polymorphism in the promoter/enhancer of FOXP3 are associated with a higher expression of FOXP3, and hypothetically with an increase of regulatory T cell activity. This polymorphism has been related to the development of auto-or alloimmune conditions including type 1 diabetes …

MaleAnálisis de supervivenciatrasplante de células madre hematopoyéticasmedicine.medical_treatmenthumanos:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysis [Medical Subject Headings]Graft vs Host Diseaselcsh:MedicinePolimorfismo genético:Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]Hematopoietic stem cell transplantationStem cellsRegiones promotoras genéticas:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Genetic Association Studies [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Trasplante homólogoIL-2 receptorLymphocytesMasculinoPromoter Regions Geneticlcsh:Sciencemediana edadancianoMultidisciplinaryAdultoFemenino:Analytical Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures Operative::Transplantation::Cell Transplantation::Stem Cell Transplantation::Hematopoietic Stem Cell Transplantation [Medical Subject Headings]Hematopoietic Stem Cell TransplantationFOXP3Forkhead Transcription Factorsadultoanálisis de supervivenciaMiddle AgedTissue DonorsHumanosestudios de asociación genéticaadulto jovenmedicine.anatomical_structuresurgical procedures operativeCèl·lules T:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Transcription Factors::Winged-Helix Transcription Factors::Forkhead Transcription Factors [Medical Subject Headings]Female:Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings]Factores de transcripción en cabeza de tenedorCèl·lules mareTrasplante de células madre hematopoyéticasResearch ArticleAdult:Named Groups::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings]GenotypeGraft-vs-Leukemia EffectRegulatory T cellAncianoT cells:Check Tags::Male [Medical Subject Headings]Graft vs Leukemia Effectfactores de transcripción en cabeza de tenedorHuman leukocyte antigenBiologyEnfermedad injerto contra huéspedLimfòcitsYoung AdultDonantes de tejidos:Named Groups::Persons::Tissue Donors [Medical Subject Headings]:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]medicineHumansTransplantation Homologous:Named Groups::Persons::Age Groups::Adult::Aged [Medical Subject Headings]Genetic Association StudiesAgedMediana edadTransplantationPolymorphism GeneticEstudios de asociación genéticaEfecto injerto contra leucemialcsh:Rdonantes de tejidostrasplante:Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism Genetic [Medical Subject Headings]medicine.diseaseSurvival Analysis:Diseases::Immune System Diseases::Graft vs Host Disease [Medical Subject Headings]Transplantation:Analytical Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures Operative::Transplantation::Transplantation Homologous [Medical Subject Headings]efecto injerto contra leucemiaGraft-versus-host disease:Check Tags::Female [Medical Subject Headings]Immunology:Phenomena and Processes::Immune System Phenomena::Immune System Processes::Transplantation Immunology::Graft vs Host Reaction::Graft vs Tumor Effect::Graft vs Leukemia Effect [Medical Subject Headings]enfermedad injerto contra huésped:Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Gene Components::Regulatory Elements Transcriptional::Promoter Regions Genetic [Medical Subject Headings]lcsh:QgenotipoGenotipoPLoS ONE
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Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis …

2018

This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity and metabolic syndrome participating in the PREDIMED-PLUS study, were assessed with a battery of cognitive tests and a medical interview. ANOVA showed a significantly worse performance on EF in type 2 diabetes vs. non-diabetic individuals. Two complementary models were displayed: (1) in the whole sample, the presence of type 2 diabetes, depressive symptoms and BMI had a direct negative ef…

MaleCross-sectional studyhumanosType 2 diabetesOverweightPersones gransBody Mass Index0302 clinical medicineOlder people diseasesMedicine030212 general & internal medicineDiabetes Treatment AdherenceCognitive declineMalalties de les persones gransmediana edad2. Zero hungerMetabolic SyndromeancianoMultidisciplinaryDiabetisCognitive ageingQDiabetesRType 2 diabetesMiddle Aged3. Good healthNeurologydiabetes mellitusMedicineObesitatFemalemedicine.symptomPREDIMEDmedicine.medical_specialtyMedicinaScienceArticle03 medical and health sciencesOlder populationDiabetes mellitusInternal medicineApnoeaHumansCognitive DysfunctionObesityobesidadAgedGlycated Hemoglobinbusiness.industryíndice de masa corporalBaseline Cross-sectional AnalysisCognitive neuroscienceCognitive Function PerformanceOverweightmedicine.diseaseObesityCross-Sectional StudiesDiabetes Mellitus Type 2StudyMetabolic syndromeOlder peoplebusinessBody mass index030217 neurology & neurosurgeryestudios transversalesGlycaemic Control
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Factors associated with edentulousness in an elderly population in Valencia (Spain)

2013

Objective: To determine the prevalence of edentulism and its association with various socioeconomic factors and oral health habits in the population aged 65-74 years old in the region of Valencia. Methods: A cross sectional study was designed. Thirty-four primary health centers and five nursing homes were chosen at random in the region of Valencia (10-15 voluntary participants per sampling point). Clinical examinations were carried out by three calibrated dentists (kappa&gt;0.85) in the same centers. The total sample consisted of 531 individuals (235 men and 296 women). Results: The percentage of toothlessness was 20.7% and the mean number of natural teeth present was 14.92. The prevalence …

MaleEncuestas de salud bucalGerontologymedicine.medical_specialtyEpidemiologyCross-sectional studyPopulationTooth lossElderlyRisk FactorsEpidemiologyPrevalenceTooth lossmedicineHumansEpidemiologíaDental health surveyseducationSocioeconomic statusAgededucation.field_of_studyEdentulismbusiness.industryPublic Health Environmental and Occupational HealthInstitutionalizationOdds ratiomedicine.diseaseCross-Sectional StudiesSocioeconomic FactorsSpainPérdida de dientesFemaleMouth EdentulousRural areamedicine.symptombusinessAncianosDemographyGaceta Sanitaria
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Physical fitness and physical activity association with cognitive function and quality of life: baseline cross-sectional analysis of the PREDIMED-Plu…

2020

Controlled Trial (ISRCTN89898870, https://www.isrctn.com/ISRCTN89898870?q=ISRCTN89898870&filters=&sort=&offset=1&totalResults=1&page=1&pageSize=10&searchType=basic-search) on 07/24/2014.

MaleEpidemiologyPhysical fitnessTrail Making Testhumanoslcsh:Medicineejercicio físicoNeuropsychological Tests0302 clinical medicineCognitionQuality of lifeMemory spanMedicineVerbal fluency test030212 general & internal medicineCognitive declinelcsh:Sciencemediana edadancianoMultidisciplinarymodelos linealesCognitionMiddle AgedQualitat de vidaCognicióFemalemedicine.medical_specialtyCognition disordersmetabolismo energéticoTrastorns de la cogniciópruebas neuropsicológicasArticle03 medical and health sciencescogniciónHumansExerciseAgedbusiness.industrylcsh:Raptitud físicaCross-Sectional StudiesPhysical Fitnesscalidad de vidaPhysical therapyQuality of LifeLinear Modelslcsh:QbusinessEnergy MetabolismNeurocognitive030217 neurology & neurosurgeryCondició físicaestudios transversales
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Factors Associated with Influenza Vaccination of Hospitalized Elderly Patients in Spain

2016

Vaccination of the elderly is an important factor in limiting the impact of influenza in the community. The aim of this study was to investigate the factors associated with influenza vaccination coverage in hospitalized patients aged ≥ 65 years hospitalized due to causes unrelated to influenza in Spain. We carried out a cross-sectional study. Bivariate analysis was performed comparing vaccinated and unvaccinated patients, taking in to account sociodemographic variables and medical risk conditions. Multivariate analysis was performed using multilevel regression models. We included 1038 patients: 602 (58%) had received the influenza vaccine in the 2013-14 season. Three or more general practit…

MaleEstudios transversalesGripeAncianoEspañaGripPneumococcal VaccinesElderlyPatient Education as TopicInfluenza HumanHumansVacunacióPacientsVacunació -- EspanyaAgedAged 80 and overVaccinesInpatientsMarital StatusVaccinationVacunaciónPneumonia PneumococcalInfluenzaCross-Sectional StudiesStreptococcus pneumoniaeSocial ClassGeriatricsSpainInfluenza A virusInfluenza VaccinesVaccination and immunizationFemaleAge groups
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