6533b855fe1ef96bd12b0ade
RESEARCH PRODUCT
Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk
Juan C. Cenoz-osinagaJuan C. Cenoz-osinagaAurora Bueno-cavanillasAurora Bueno-cavanillasAlejandro Oncina CanovasItziar AbeteJosep A. TurChristopher PapandreouPilar Matía-martínMiguel Delgado-rodríguezMiguel Delgado-rodríguezMireia QuiferNerea Becerra-tomásLidia DaimielLucas Tojal SierraRosa CasasRosa CasasLaura M Compañ GabucioMònica BullóAlmudena Sanchez VillegasAlmudena Sánchez-villegasHelmut SchröderMiguel ÁNgel Martínez-gonzálezMiguel ÁNgel Martínez-gonzálezMiguel ÁNgel Martínez-gonzálezClotilde VázquezAntoni ColomJordi Salas-salvadóJulia WärnbergJulia WärnbergMiguel Ruiz-canelaMiguel Ruiz-canelaDolores CorellaDolores CorellaJosep VidalJosé V SorlíJosé V. SorlíDora RomagueraOlga CastañerLluis Serra-majemLluis Serra-majemMaria Del Mar BibiloniAndrés Díaz-lópezVicente Martín-sánchezVicente Martín-sánchezNapoleón Pérez-farinósNapoleón Pérez-farinósÁNgel M. Alonso-gómezEmilio RosEmilio RosEva M. AsensioEva M. AsensioAlfredo MartínezAlfredo MartínezXavier PintóAntonio Garcia-riosAntonio Garcia-riosMarga MoreyMarga MoreyJavier Barón-lópezJavier Barón-lópezJesús VioqueLaura TorrasJavier Díez-espinoJavier Díez-espinoJosé Carlos Fernández-garcíaJosé Carlos Fernández-garcíaRamon EstruchRamon EstruchJosé LapetraAraceli Muñoz-garachAraceli Muñoz-garachNancy BabioJosé Manuel Santos-lozanoEmili CorbellaItziar Salaverria-letesubject
Male0301 basic medicinesueñoNefrología y urologíahumanosserum uric acid to creatinine ratioOverweightchemistry.chemical_compound0302 clinical medicineRisk FactorsMedicinemediana edadancianoeducation.field_of_studyNutrition and DieteticsMediterranean RegionCommunicationácido úricoMiddle AgedcreatininaSleep in non-human animals3. Good healthCardiovascular DiseasesCreatinineObesitatFemalemedicine.symptomlcsh:Nutrition. Foods and food supplymedicine.medical_specialtyserum uric acidPopulationenfermedades cardiovascularesDietética y nutriciónlcsh:TX341-641Cardiología03 medical and health sciences:Ciencias de la Salud::Medicina preventiva [Materias Investigacion]Internal medicineHumansfactores de riesgoObesityeducationAgedCreatininebusiness.industryActigraphymedicine.diseaseObesityactigraphy serum uric acid serum uric acid to creatinine ratio sleep durationSonUric AcidÀcid úricCross-Sectional Studies030104 developmental biologyEndocrinologychemistrySpainUric acidsleep durationMetabolic syndromebusinessSleepUric acidBiomarkers030217 neurology & neurosurgeryestudios transversalesFood Scienceactigraphydescription
The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly participants with overweight/obesity and metabolic syndrome in the (Prevencion con Dieta Mediterranea) PREDIMED-Plus trial. Accelerometry-derived sleep duration and sleep variability were measured. Linear regression models were fitted to examine the aforementioned associations. A 1 hour/night increment in sleep duration was inversely associated with SUA concentrations ( = -0.07, p = 0.047). Further adjustment for leukocytes attenuated this association (p = 0.050). Each 1-hour increment in sleep duration was inversely associated with SUA to creatinine ratio ( = -0.15, p = 0.001). The findings of this study suggest that longer sleep duration is associated with lower SUA concentrations and lower SUA to creatinine ratio.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-04-01 |