Search results for "Anus"
showing 10 items of 841 documents
Self-assembly of janus dendrimers into uniform dendrimersomes and other complex architectures
2010
Janus Drug Delivery Vehicle Efficient drug delivery vehicles need to be produced in a limited size range and with uniform size distribution. The self-assembly of traditional small-molecule and polymeric amphiphiles has led to the production of micelles, liposomes, polymeric micelles, and polymersomes for use in drug delivery applications. Now, Percec et al. (p. 1009 ) describe the self-assembly of Janus-type (i.e., two-headed) dendrimers to produce monodisperse supramolecular constructs, termed “dendrimersomes,” and other complex architectures. The structures, which showed long-term stability as well as very narrow size distributions, were easily produced by the injection of an ethanolic so…
Pharmacology and safety of tofacitinib in ulcerative colitis.
2020
The use of Janus kinase (JAK) inhibitors is a new approach in the therapy of inflammatory diseases with immune base. Tofacitinib is one of these inhibitors targeting JAK1 and JAK3, and its efficacy has been demonstrated in the treatment of moderate to severe ulcerative colitis (UC). It is a small synthetic molecule administered orally, with a fast bioavailability and elimination rate, predictable pharmacokinetics and lack of immunogenicity, which are convenient characteristics for both efficacy and safety. This article reviews the pharmacological characteristics of tofacitinib and its safety profile.
Matheus Molanus, in G. C. SCIOLLA (a cura di), Cielo terra e acque: il paesaggio nella pittura fiamminga e olandese tra Cinquecento e Seicento, Torin…
2006
Matheus Molanus, in G. C. SCIOLLA (a cura di), Cielo terra e acque: il paesaggio nella pittura fiamminga e olandese tra Cinquecento e Seicento, Torino, Elede, 2006 p. 35-133
Synthetic antitumor vaccines containing MUC1 glycopeptides with two immunodominant domains-induction of a strong immune response against breast tumor…
2011
A shot in the arm for cancer treatment: two MUC1 tetanus toxoid vaccines were synthesized and induced a strong immune response in mice. The antibodies elicited by the vaccines show a high selectivity for the tumor cells in mammary carcinoma tissues and also distinguish between tumor tissues at different stages.
Enzyme-accelerated and structure-guided crystallization of calcium carbonate: Role of the carbonic anhydrase in the homologous system
2014
Abstract The calcareous spicules from sponges, e.g. from Sycon raphanus, are composed of almost pure calcium carbonate. In order to elucidate the formation of those structural skeletal elements, the function of the enzyme carbonic anhydrase (CA), isolated from this species, during the in vitro calcium carbonate-based spicule formation, was investigated. It is shown that the recombinant sponge CA substantially accelerates calcium carbonate formation in the in vitro diffusion assay. A stoichiometric calculation revealed that the turnover rate of the sponge CA during the calcification process amounts to 25 CO2 s−1 × molecule CA−1. During this enzymatically driven process, initially pat-like pa…
Liquid methane at extreme temperature and pressure: Implications for models of Uranus and Neptune
2012
We present large scale electronic structure based molecular dynamics simulations of liquid methane at planetary conditions. In particular, we address the controversy of whether or not the interior of Uranus and Neptune consists of diamond. In our simulations we find no evidence for the formation of diamond, but rather sp2-bonded polymeric carbon. Furthermore, we predict that at high tem- perature hydrogen may exist in its monoatomic and metallic state. The implications of our finding for the planetary models of Uranus and Neptune are in detail discussed.
The Antigerminative Activity of Twenty-Seven Monoterpenes
2010
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Los motivos caballerescos del manuscrito encontrado y el falso cronista en El Señor de los Anillos
2013
El manuscrito encontrado es uno de los motivos presentes en la mayoría de los libros de caballerías y, si bien se trata de un elemento de origen remoto, su frecuente aparición en estas obras, ha hecho que se convierta en uno de sus rasgos característicos. En este artículo se pone de manifiesto la forma en que se plasma este mismo motivo en El Señor de los Anillos de J.R.R. Tolkien, autor que tenía una especial vinculación con la literatura medieval y con lo hispánico.
: Noeud visuel, site monastique, production d'image
2018
Le manuscrit 1 conservé à la Bibliothèque municipale de Semur est l’un des plus anciens manuscrits conservés en Bourgogne, sinon le plus ancien, pour les uns à dater autour de l’an mil, pour les autres à rattacher, vers la même époque, au grand mouvement des « abbés réformateurs » et aux livrets hagio-liturgiques de prestige. C’est un recueil composite, de 260 mm par 207, comprenant 78 feuillets réunis en cahiers, et provenant de l’abbaye de Saint-Jean de Réôme (Moutiers-Saint-Jean), en Côte-d’Or. Les différentes pièces qui le composent furent probablement réalisées entre le Xe et le XVe siècle ; la reliure en carton date de 1834.Au fil de son histoire, au cours des différentes étapes de sa…
Hagiographie et diplomatique dans le monachisme réformé en Bourgogne au miroir du manuscrit 1 de Semur-en-Auxois
2014
International audience; Le propos de cet article est, à partir de l'exemple du manuscrit 1 de la Bibliothèque municipale de Semur-en-Auxois, de penser la question de la transtextualité, en empruntant cette notion à la théorie littéraire, tout en la restituant non seulement en fonction du texte de l'énoncé, mais également en relation aux signes visuels et matériels de la mise par écrit, « la raison graphique », sur la longue durée. Il s'agit aussi d'interroger le rôle des différents chantiers scripturaires propres à la "renovatio" monastique au tournant des X e et XI e siècles, comme l'un des moyens de « mise en norme » dans le cadre d'une redéfinition plus large de la place occupée par les …