Search results for "Apigenin"
showing 10 items of 34 documents
Induction of Apoptosis, Autophagy and Ferroptosis by Thymus vulgaris and Arctium lappa Extract in Leukemia and Multiple Myeloma Cell Lines
2020
Thymus vulgaris and Arctium lappa have been used as a folk remedy in the Iraqi Kurdistan region to deal with different health problems. The aim of the current study is to investigate the cytotoxicity of T. vulgaris and A. lappa in leukemia and multiple myeloma (MM) cell lines and determine the mode of cell death triggered by the most potent cytotoxic fractions of both plants in MM. Resazurin assay was used to evaluate cytotoxic and ferroptosis activity, apoptosis, and modulation in the cell cycle phase were investigated via Annexin V-FITC/PI dual stain and cell-cycle arrest assays. Furthermore, we used western blotting assay for the determination of autophagy cell death. n-Hexane, chlorofor…
Phenolic glycosides from Phagnalon rupestre.
2002
Analysis of the butanol-soluble fraction from the methanolic extract of the aerial parts of Phagnalon rupestre (Asteraceae) has led to the isolation of seven phenolic compounds. Three have been identified on the basis of their NMR spectra as new natural compounds: the lignan 7,7'-bis-(4-hydroxy-3,5-dimethoxyphenyl)-8,8'-dihydroxymethyl-tetrahydrofuran-4-O-beta-glucopyranoside (1), the prenylhydroquinone glycoside 1-O-beta-glucopyranosyl-1,4-dihydroxy-2-(3'-hydroxy-3'-methylbutyl) benzene (2) and the acetophenone glycoside 12-O-beta-glucopyranosyl-9beta,12-dihydroxytremetone (3). The known flavonoids apigenin-7-O-beta-glucoside, luteolin-7-O-beta-glucoside, luteolin-7-O-beta-glucuronide and …
Apigenin‐induced nitric oxide production involves calcium‐activated potassium channels and is responsible for antiangiogenic effects
2007
Summary. Background: The dietary flavonoid apigenin (Api) has been demonstrated to exert multiple beneficial effects upon the vascular endothelium. The aim of this study was to examine whether Ca2+-activated K+ channels (KCa) are involved in endothelial nitric oxide (NO) production and antiangiogenic effects.Methods: Endothelial NO generation was monitored using a cyclic guanosine monophosphate radioimmunoassay. KCa activity and changes of the intracellular Ca2+ concentration [Ca2+]i were analyzed using the fluorescent dyes bis-barbituric acid oxonol, potassium-binding benzofuran isophthalate, and fluo-3. The endothelial angiogenic parameters measured were cell proliferation, [3H]-thymidine…
Enzyme pretreatment and negative pressure cavitation extraction of genistein and apigenin from the roots of pigeon pea [Cajanus cajan (L.) Millsp.] a…
2012
Abstract An enzyme pretreatment and negative-pressure cavitation extraction (E-NPCE) method was investigated for extraction genistein and apigenin from pigeon pea roots. The important parameters involved in E-NPCE process were optimized by single-factor experiments and then critical parameters were investigated by a 2 3 full factorial central composite design (CCD) to optimize extract conditions. Under optimal conditions, the yields of genistein and apigenin were 0.628 mg/g and 0.359 mg/g, which represented an increase of 44.70% and 53.05%, respectively, compared to standard NPCE. Furthermore, from DPPH scavenging activity test the extract of E-NPCE showed better antioxidant activity than t…
Antioxidant properties, superoxide dismutase and glutathione reductase activities in HepG2 cells with a fungal endophyte producing apigenin from pige…
2012
Abstract A fungal endophyte MD89 with obvious antioxidant activities was isolated from pigeon pea and identified as Chaetomium globosum by ITS sequence. Different fractions from MD89 culture were compared and evaluated by total phenol (TP) content, total flavonoid (TFL) content, DPPH radical scavenging, reducing power and lipid peroxidation assays, respectively. Results showed that EtOAc extracts had high content of TP and TFL, and strong antioxidant activities (IC 50 value was 6.87, 15.19, 16.78 μg/mL, respectively). Furthermore, the EtOAc extracts were analyzed by LC–MS/MS and a good antioxidant compound, apigenin, was found. The activities of superoxide dismutase (SOD) and glutathione re…
Über die Verbreitung von Flavonoiden bei pleurokarpen Laubmoosen I. Apigenin-7-rhamnoglucosid bei Hylocomium splendens (Hedw.) Br. eur.
1977
Summary 15 species of pleurocarpous mosses have been investigated as to their content of flavonoids. Flavonoid tests on 14 species have given negative results. Only one species, Hylocomium splendens , contains one flavonoid. It was purified by means of paper chromatography and is by chromatography and absorption spectrum identical with rhoifolin (apigenin-7-neohesperidoside). Partial acid hydrolysis yields apigenin-7-monoglucoside and rhamnose, quantitative hydrolysis apigenin, rhamnose and glucose. They were identified by comparison with authentic samples.
Über die Verbreitung von Flavonoiden bei pleurokarpen Laubmoosen II. Apigenin and Apigenin-7-rhamnoglucosid bei Pleurozium schreberi (Willd.) Mitt.
1980
Summary 12 species of pleurocarpous mosses have been investigated as to their content of flavonoids. Flavonoid tests on 11 species have given negative results. Only one species, Pleurozium schreberi , contains three flavonoids. They were purified by means of paper chromatography. Two of them are by chromatography, acid hydrolysis and absorption spectrum identical with apigenin and apigenin-7-rhamnoglucoside. The third flavonoid is as yet unidentified. Qualitative hydrolysis yields apigenin. The chemotaxonomic importance of the results is briefly discussed.
Flavones, sesquiterpene lactones and glycosides isolated from Centaurea aspera var. Stenophylla
1984
Abstract From the alcoholic extract of Centaurea aspera var. stenophylla benzoic acid, p-hydroxybenzoic acid, apigenin, 6-methoxyluteolin, 11,13-dehydromelitensin, melitensin, stenophyliolide, ethyl-7-O-apigenin-glucuronate and the glucosides of sitosterol and stigmasterol were isolated and characterized. Stenophyllolide was shown to be 9,15-dihydroxygermacra-1(10),4,11-trien-12,6-olide.
A chemotaxonomic survey of Sonchus subgenus Sonchus
1993
Abstract Five species of Sonchus subgenus Sonchus were surveyed for their phenolic constituents. Seven flavonoids were identified: luteolin, luteolin-7-glucoside, apigenin, apigenin-3-glucoside, quercetin, quercetin-3-glucoside and quercetin-3-galactoside; three were phenolic acids; caffeic, chlorogenic and isochlorogenic; and two were coumarins: aesculetin and cichoriin. Their systematic significance for this genus is discussed.
Phenylethanoid glycosides from Prostanthera melissifolia
1999
Abstract Six phenylethanoid glycosides were isolated from aerial parts of Prostanthera melissifolia, together with apigenin and ursolic acid. The glycosides were characterized by spectral methods as martynoside, isomartynoside, verbascoside, isoverbascoside, betonyoside F and isobetonyoside F, the latter being a new natural product.