Search results for "Applications"

Coupling BEM and VEM for the Analysis of Composite Materials with Damage

2021

Numerical tools which are able to predict and explain the initiation and propagation of damage at the microscopic level in heterogeneous materials are of high interest for the analysis and design of modern materials. In this contribution, we report the application of a recently developed numerical scheme based on the coupling between the Virtual Element Method (VEM) and the Boundary Element Method (BEM) within the framework of continuum damage mechanics (CDM) to analyze the progressive loss of material integrity in heterogeneous materials with complex microstructures. VEM is a novel numerical technique that, allowing the use of general polygonal mesh elements, assures conspicuous simplific…

Brain Tumor-Derived Extracellular Vesicles as Carriers of Disease Markers: Molecular Chaperones and MicroRNAs

2020

Primary and metastatic brain tumors are usually serious conditions with poor prognosis, which reveal the urgent need of developing rapid diagnostic tools and efficacious treatments. To achieve these objectives, progress must be made in the understanding of brain tumor biology, for example, how they resist natural defenses and therapeutic intervention. One resistance mechanism involves extracellular vesicles that are released by tumors to meet target cells nearby or distant via circulation and reprogram them by introducing their cargo. This consists of different molecules among which are microRNAs (miRNAs) and molecular chaperones, the focus of this article. miRNAs modify target cells in the…

Can 3D Digital Breast Tomosynthesis (DBT) improve breast malignant pathology detection? A case-to-case imaging comparison between 3D DBT and 2D Mammo…

2014

Learning objectives Background Findings and procedure details Conclusion Personal information References

Growth of immobilized DNA by polymerase: bridging nanoelectrodes with individual dsDNA molecules.

2011

We present a method for controlled connection of gold electrodes with dsDNA molecules (locally on a chip) by utilizing polymerase to elongate single-stranded DNA primers attached to the electrodes. Thiol-modified oligonucleotides are directed and immobilized to nanoscale electrodes by means of dielectrophoretic trapping, and extended in a procedure mimicking PCR, finally forming a complete dsDNA molecule bridging the gap between the electrodes. The technique opens up opportunities for building from the bottom-up, for detection and sensing applications, and also for molecular electronics.

Torre para comunicaciones y prácticas de bomberos en la Eliana, Valencia. España

1992

The article brings the description of the characteristics of the project and the execution of the work on a communication tower which should also serve for practices of fire brigades and which has a water tank in the base.

Variable-order reference-free variant discovery with the Burrows-Wheeler Transform

2020

Abstract Background In [Prezza et al., AMB 2019], a new reference-free and alignment-free framework for the detection of SNPs was suggested and tested. The framework, based on the Burrows-Wheeler Transform (BWT), significantly improves sensitivity and precision of previous de Bruijn graphs based tools by overcoming several of their limitations, namely: (i) the need to establish a fixed value, usually small, for the order k, (ii) the loss of important information such as k-mer coverage and adjacency of k-mers within the same read, and (iii) bad performance in repeated regions longer than k bases. The preliminary tool, however, was able to identify only SNPs and it was too slow and memory con…

Burrows–Wheeler transform and Sturmian words

2003

ProcessWiki: A Contribution for Bridging the Last Mile Problem in Automotive Retail

2012

In many real-world business process management (BPM) installments, the benefit of BPM is diminished by an insufficient implementation of the to-be business processes. One of the key reasons for this problem is the complexity of classical process modeling representations that exceed the BPM knowledge of many target groups.

Handling Evolving Data Warehouse Requirements

2015

A data warehouse is a dynamic environment and its business requirements tend to evolve over time, therefore, it is necessary not only to handle changes in data warehouse data, but also to adjust a data warehouse schema in accordance with changes in requirements. In this paper, we propose an approach to propagate modified data warehouse requirements in data warehouse schemata. The approach supports versions of data warehouse schemata and employs the requirements formalization metamodel and multiversion data warehouse metamodel to identify necessary changes in a data warehouse.

A COMPARATIVE STUDY BETWEEN ´ BIHARMONIC BEZIER SURFACES AND BIHARMONIC EXTREMAL SURFACES

2009

AbstractGiven a prescribed boundary of a Bezier surface, we compare the Bezier surfaces generated by two different methods, i.e., the Bezier surface minimising the biharmonic functional and the unique Bezier surface solution of the biharmonic equation with prescribed boundary. Although often the two types of surfaces look visually the same, we show that they are indeed different. In this paper, we provide a theoretical argument showing why the two types of surfaces are not always the same.