Search results for "Apse"
showing 10 items of 1903 documents
Fenomenografinen tutkimus lasten koululaisuuskäsityksistä ja niiden rakentumisesta ekologisissa ympäristöissä
2011
TIIVISTELMÄ Siitonen, Inkeri. 2011. KOULULAISUUS ESIOPETUSIKÄISTEN LASTEN SILMIN. Fenomenografinen tutkimus lasten koululaisuuskäsityksistä ja niiden rakentumisesta ekologisissa ympäristöissä. Varhaiskasvatustieteen pro gradu -tutkielma, Jyväskylän yliopisto, Kasvatustieteiden laitos, Varhaiskasvatuksen yksikkö. 150 sivua + liitteet. Tutkimuksen aiheena olivat lasten koululaisuuteen liittyvät käsitykset ja niiden rakentuminen lapsen ekologisissa ympäristöissä esiopetusvuoden aikana. Tutkimuksen tarkoituksena oli tuottaa tietoa siitä, millaisin käsityksin esiopetusikäiset lapset lähestyvät koulun aloitusta. Tämä on tärkeä tieto suunniteltaessa lapsilähtöistä kouluun siirtymää. Tutkimus on kv…
Non-syndromic Mitral Valve Dysplasia Mutation Changes the Force Resilience and Interaction of Human Filamin A
2018
International audience; Filamin A (FLNa), expressed in endocardial endothelia during fetal valve morphogenesis, is key in cardiac development. Missense mutations in FLNa cause non-syndromic mitral valve dysplasia (FLNA-MVD). Here, we aimed to reveal the currently unknown underlying molecular mechanism behind FLNA-MVD caused by the FLNa P637Q mutation. The solved crystal structure of the FLNa3-5 P637Q revealed that this mutation causes only minor structural changes close to mutation site. These changes were observed to significantly affect FLNa's ability to transmit cellular force and to interact with its binding partner. The performed steered molecular dynamics simulations showed that signi…
Projekts: Kokapstrādes uzņēmums SIA "ASP KZ"
2016
Maģistra darbs Projekts: „Kokapstrādes uzņēmums SIA „ASP KZ”” izstrādāts biznesa plāna formā, plānojot uzņēmuma dibināšanas kārtību, darbības principus, produktus, mārketinga aktivitātes, finanšu plānu un risku vadību. Maģistra darba mērķis ir izveidot ilgtspējīgu biznesa projektu – kokapstrādes uzņēmumu, kas specializēsies apses koka apstrādē, koksnes un koka izstrādājumu ražošana. Uzņēmuma pamatdarbība ir pirts un saunu apdares materiālu ražošana no apses (pirts un saunu sienu paneļi, lāvas dēļi un profilētas līstes). Apses koka dēļi ir nišas produkts, jo, neskatoties uz lielo kokapstrādes uzņēmumu skaitu Latvijā, apses dēļu ražošanā veiksmīgi specializējas tikai daži uzņēmumi. Konkurence…
Dendrites are dispensable for basic motoneuron function but essential for fine tuning of behavior.
2014
Dendrites are highly complex 3D structures that define neuronal morphology and connectivity and are the predominant sites for synaptic input. Defects in dendritic structure are highly consistent correlates of brain diseases. However, the precise consequences of dendritic structure defects for neuronal function and behavioral performance remain unknown. Here we probe dendritic function by using genetic tools to selectively abolish dendrites in identified Drosophila wing motoneurons without affecting other neuronal properties. We find that these motoneuron dendrites are unexpectedly dispensable for synaptic targeting, qualitatively normal neuronal activity patterns during behavior, and basic …
Advantage of rare infanticide strategies in an invasion experiment of behavioural polymorphism
2012
Killing conspecific infants (infanticide) is among the most puzzling phenomena in nature. Stable polymorphism in such behaviour could be maintained by negative frequency-dependent selection (benefit of rare types). However, it is currently unknown whether there is genetic polymorphism in infanticidal behaviour or whether infanticide may have any fitness advantages when rare. Here we show genetic polymorphism in non-parental infanticide. Our novel invasion experiment confirms negative frequency-dependent selection in wild bank vole populations, where resource benefits allow an infanticidal strategy to invade a population of non-infanticidal individuals. The results show that infanticidal beh…
Reduction in the Motoneuron Inhibitory/Excitatory Synaptic Ratio in an Early-Symptomatic Mouse Model of Amyotrophic Lateral Sclerosis
2010
Excitotoxicity is a widely studied mechanism underlying motoneuron degeneration in amyotrophic lateral sclerosis (ALS). Synaptic alterations that produce an imbalance in the ratio of inhibitory/excitatory synapses are expected to promote or protect against motoneuron excitotoxicity. In ALS patients, motoneurons suffer a reduction in their synaptic coverage, as in the transition from the presymptomatic (2-month-old) to early-symptomatic (3-month-old) stage of the hSOD1(G93A) mouse model of familial ALS. Net synapse loss resulted from inhibitory bouton loss and excitatory synapse gain. Furthermore, in 3-month-old transgenic mice, remaining inhibitory but not excitatory boutons attached to mot…
Identification of the cannabinoid receptor type 1 in serotonergic cells of raphe nuclei in mice.
2007
The endocannabinoid system (ECS) possesses neuromodulatory functions by influencing the release of various neurotransmitters, including GABA, noradrenaline, dopamine, glutamate and acetylcholine. Even though there are studies indicating similar interactions between the ECS and the serotonergic system, there are no results showing clear evidence for type 1 cannabinoid receptor (CB1) location on serotonergic neurons. In this study, we show by in situ hybridization that a low but significant fraction of serotonergic neurons in the raphe nuclei of mice contains CB1 mRNA as illustrated by the coexpression with the serotonergic marker gene tryptophane hydroxylase 2, the rate limiting enzyme for t…
Usher syndrome: molecular links of pathogenesis, proteins and pathways.
2006
Contains fulltext : 50437.pdf (Publisher’s version ) (Closed access) Usher syndrome is the most common form of deaf-blindness. The syndrome is both clinically and genetically heterogeneous, and to date, eight causative genes have been identified. The proteins encoded by these genes are part of a dynamic protein complex that is present in hair cells of the inner ear and in photoreceptor cells of the retina. The localization of the Usher proteins and the phenotype in animal models indicate that the Usher protein complex is essential in the morphogenesis of the stereocilia bundle in hair cells and in the calycal processes of photoreceptor cells. In addition, the Usher proteins are important in…
Deletion of myosin VI causes slow retinal optic neuropathy and age-related macular degeneration (AMD)-relevant retinal phenotype
2015
The unconventional myosin VI, a member of the actin-based motor protein family of myosins, is expressed in the retina. Its deletion was previously shown to reduce amplitudes of the a- and b-waves of the electroretinogram. Analyzing wild-type and myosin VI-deficient Snell’s Waltzer mice in more detail, the expression pattern of myosin VI in retinal pigment epithelium, outer limiting membrane, and outer plexiform layer could be linked with differential progressing ocular deficits. These encompassed reduced a-waves and b-waves and disturbed oscillatory potentials in the electroretinogram, photoreceptor cell death, retinal microglia infiltration, and formation of basal laminar deposits. A pheno…
Geografie del collasso. L'Antropocene in 9 parole chiave
2021
Covid-19 è il primo grande trauma collettivo dell’Antropocene, una catena di eventi materiali, culturali e sociali che stanno aggredendo il nostro immaginario con un impatto incalcolabile. Un effetto profondo della pandemia sarà costringere l’umanità al prossimo step cognitivo: l’accettazione della fine della pace climatica dell’Olocene. Abbiamo bisogno di tempo, ma il tempo a disposizione è poco. Negare il trauma, fare come l’erbivoro assalito dalla belva che si anestetizza per non vedere la fine è qualcosa che non possiamo permetterci. Dissoluzione degli ecosistemi terrestri, questione animale, mutamento climatico, inquinamento e dissesto demografico, diaspora, populismo, suprematismo, er…