Search results for "Apse"

How to Become an Author: The Poet Isa Asp and Her Childhood Fascination with Writing for Magazines

2021

In this article the author explores the early development of the identity as a writer of a Finnish-speaking poet Lovisa (or Isa) Asp (1853–1872). She wrote her lyrics in the Finnish language in the 1870s, and she is regarded as the first 19th-century female Finnish poet (whose works were published in Finnish). She began writing poetry (initially in Swedish) as a teenager and started her literary career as a contributor to children’s magazines. Asp began her studies at the Teacher Training College in Jyväskylä in autumn 1871 with the aim of working as an elementary school teacher, but she also dreamt of becoming an established writer someday. Unfortunately, her early death meant that most of…

Jälleenrakentamisen ajan lapsesta tulevaisuuden lapseen : suomalaisten lastenkirjojen lapsikäsitykset ja sosiologinen lapsitutkimus

1998

Literacy skills seem to fuel literacy enjoyment, rather than vice versa

2023

Children who like to read and write tend to be better at it. This association is typically interpreted as enjoyment impacting engagement in literacy activities, which boosts literacy skills. We fitted direction-of-causation models to partial data of 3690 Finnish twins aged 12. Literacy skills were rated by the twins' teachers and literacy enjoyment by the twins themselves. A bivariate twin model showed substantial genetic influences on literacy skills (70%) and literacy enjoyment (35%). In both skills and enjoyment, shared-environmental influences explained about 20% in each. The best-fitting direction-of-causation model showed that skills impacted enjoyment, while the influence in the othe…

Izotopu attiecību masspektrometrijas metodes pielietojums hibrīdapses (Populus Tretmula L. x P.Tremuloides Michx) dendroķīmiskajos pētījumos

2020

Darbā apkopota informācija par izotopu attiecībām masspektometrijā un hibrīdapšu dendroķīmiju, lai izpētītu gaisa piesārņojumu pagātnē. Tika pētīti koka paraugi, kas auguši dažādi mēslotos parauglaukumos. Koka paraugs iegūts no hibrīdapses (Populus Tretmula L. × P. Tremuloides Michx). Bakalaura darba ietvaros tika analizētas C un N izotopu attiecības. Iegūtie rezultāti tika izvērtēti un pētītas likumsakarības par izotopu attiecībām.

Cytoskeletal stabilization of inhibitory interactions in immunologic synapses of mature human dendritic cells with natural killer cells

2011

Abstract Human mature dendritic cells (DCs) can efficiently stimulate natural killer (NK)–cell responses without being targeted by their cytotoxicity. To understand this important regulatory crosstalk, we characterized the development of the immunologic synapse between mature DCs and resting NK cells. Conjugates between these 2 innate leukocyte populations formed rapidly, persisted for prolonged time periods and matured with DC-derived f-actin polymerization at the synapse. Polarization of IL-12 and IL-12R to the synapse coincided with f-actin polymerization, while other activating and inhibitory molecules were enriched at the interface between DCs and NK cells earlier. Functional assays re…

Similar morphokinetic patterns in embryos derived from obese and normoweight infertile women: a time-lapse study.

2013

Study question Does female obesity affect the dynamic parameters of embryo quality assessed by time-lapse analysis? Summary answer Female obesity does not affect the dynamic embryo quality as determined by image acquisition and time-lapse analysis. What is known already Female obesity impairs natural and assisted reproduction but there is no agreement on the specific contribution of gametes, embryos or endometrial receptivity. In this preliminary study the dynamic parameters of embryo quality are assessed for the first time by time-lapse analysis. Study design, size, duration Two-year cohort retrospective study comparing embryos from three groups of patients according to the presence of inf…

Macroelement Model for the Progressive-Collapse Analysis of Infilled Frames

2021

A new multistrut macromodel for the analysis of the progressive-collapse response of infilled reinforced concrete (RC) frames is presented in this paper. The model consists of three struts: two outer infinitely rigid and resistant struts and one inner fiber-section strut. The inclination of the struts as well as the stress-strain response are modulated by two parameters that are obtained by means of analytical correlations provided in the paper. The latter link the geometric and mechanical properties of an infilled frame to the geometric configuration and mechanical response of the equivalent strut model. This confers the model the capability to adapt to consider different collapse configur…

An Ehrenfeucht-Fraïssé Approach to Collapse Results for First-Order Queries over Embedded Databases

2001

We present a new proof technique for collapse results for first-order queries on databases which are embedded in N or R>o. Our proofs are by means of an explicitly constructed winning strategy for Duplicator in an Ehrenfeucht-FraissE game, and can deal with certain infinite databases where previous, highly involved methods fail. Our main result is that first-order logic has the natural-generic collapse over {N,≤ ,+} for arbitrary (i.e., possibly infinite) databases. Furthermore, a first application of this result shows the natural-generic collapse of first-order logic over {R>o,≤,+} for a certain kind of databases over R>o which consist of a possibly infinite number of regions.

Improving extracellular vesicles visualization: From static to motion

2020

AbstractIn the last decade, extracellular vesicles (EVs) have become a hot topic. The findings on EVs content and effects have made them a major field of interest in cancer research. EVs, are able to be internalized through integrins expressed in parental cells, in a tissue specific manner, as a key step of cancer progression and pre-metastatic niche formation. However, this specificity might lead to new opportunities in cancer treatment by using EVs as devices for drug delivery. For future applications of EVs in cancer, improved protocols and methods for EVs isolation and visualization are required. Our group has put efforts on developing a protocol able to track the EVs for in vivo intern…

Endothelial Nitric Oxide Synthase Regulates T Cell Receptor Signaling at the Immunological Synapse

2006

The role of nitric oxide (NO) in T cells remains controversial, and the origin and localization of endogenous NO and whether it regulates lymphocyte activation are unclear. We show here that, within minutes of binding to antigen, T cells produce NO via endothelial nitric oxide synthase (eNOS). This process required increased intracellular Ca2+ and phosphoinositide3-kinase activity. By using an eNOS-green fluorescent fusion protein and fluorescent probes to detect NO, we show that eNOS translocates with the Golgi apparatus to the immune synapse of T helper cells engaged with antigen-presenting cells (APC), where it was fully activated. Overexpression of eNOS prevented the central coalescence…