Search results for "Arid"
showing 10 items of 1382 documents
Radiation-tailored xyloglucan-doxorubicin nanoparticles for cancer therapy
2022
Polysaccharides are long chains of monosaccharides linked by glycosidic bonds. They are widely utilized in biomedical applications, for tissue engineering and wound management, and as excipients of pharmaceutical formulations. In cancer therapy, the development of nanoscale drug delivery systems aims at addressing issues related to the low efficacy of chemotherapeutics and protein drugs due to poor solubility and stability, and to off-target effects that severely affect patients’ body conditions. Biocompatibility, availability of functional groups, amenability of chemical derivatisation and multifunctional conjugation with drugs and targeting ligands make polysaccharide nanoparticles intere…
Spine and test skeletal matrices of the Mediterranean sea urchinArbacia lixula- a comparative characterization of their sugar signature
2015
15 pages; International audience; Calcified structures of sea urchins are biocomposite materials that comprise a minor fraction of organic macromolecules, such as proteins, glycoproteins and polysaccharides. These macromolecules are thought to collectively regulate mineral deposition during the process of calcification. When occluded, they modify the properties of the mineral. In the present study, the organic matrices (both soluble and insoluble in acetic acid) of spines and tests from the Mediterranean black sea urchin Arbacia lixula were extracted and characterized, in order to determine whether they exhibit similar biochemical signatures. Bulk characterizations were performed by mono-di…
Educación para el Desarrollo Sostenible: investigación analítico-crítica de los proyectos de Educación Ambiental del Ayuntamiento de Valencia, España
2014
Esta tesis doctoral, vinculada a la comprensión de la educación como herramienta esencial para el desarrollo sostenible, se insiere en las discusiones que se están llevando a cabo en el marco de la declaración del Decenio de la Educación para el Desarrollo Sostenible (DEDS)(2005-2014). Su objeto de estudio se centra en la adecuación pedagógica de los proyectos de Educación Ambiental (EA) llevados a cabo por la Concejalía de Educación Ambiental del Ayuntamiento de Valencia, en el período académico 2011-2012, a los principios pedagógicos de la Educación Ambiental (complejidad e interdisciplinariedad, constructivismo, diálogo y criticidad). Se trata de un estudio etnográfico desarrollado atrav…
219 Incidence Testing of Hunter Syndrome in A Population at Risk - First Results of A Binational Screening Programme
2012
Background Hunter syndrome (Mucopolysaccharidosis type II; X-linked inheritance; prevalence rate in Europe approximately 1:77000 male newborns) is a rare, progressive, multisystemic disease, caused by deficiency of the lysosomal enzyme Iduronate-2-sulfatase. Due to the very heterogeneous phenotype Hunter syndrome is often not diagnosed before pre-school age. This is unfortunate, because patients would significantly benefit from the earliest possible start of treatment containing enzyme replacement therapy. Early screening methods are possible, but due to the rarity of this disease they are too expensive to be performed in all newborns. An at-risk patient population screening provides opport…
Limitations of population models in predicting climate change effects : a simulation study of sociable weavers in southern Africa
2008
Current approaches for predicting climate change effects on populations comprise static models based on the geographical distribution of species, and dynamic population models based on the relationship between population processes and the recent variation in climate. Population models have the inherent advantage of considering a species' response to climate as resulting from distinct mechanisms. However, they may have the disadvantage of considering only short-term processes as they occur under the current climate, disregarding slowly adapting mechanisms. It would be important, however, to know whether slowly adapting processes occur, and whether they will respond to climate change. A way o…
The endopolygalacturonase 1 from botrytis cinerea activates grapevine defense reactions unrelated to its enzyumatic activity
2003
A purified glycoprotein from Botrytis cinerea(strain T4), identified as endopolygalacturonase 1 (T4BcPG1) by mass spectrometry analysis, has been shown to activate defense reactions in grapevine (Vitis vinifera cv. Gamay). These reactions include calcium influx, production of active oxygen species, activation of two mitogen-activated protein kinases, defense gene transcript accumulation, and phytoalexin production. Most of these defense reactions were also activated in grapevine in response to purified oligogalacturonides (OGA) with a degree of polymerization of 9 to 20. In vivo, these active OGA might be a part of the released products resulting from endopolygalacturonase activity on plan…
Partition of volatile compounds in pea globulin–maltodextrin aqueous two-phase system
2014
International audience; This study is based on the assumption that the off-flavour of pea proteins might be decreased using the retention of volatile compounds by a mixture with another biopolymer. The partition of volatile compounds in an aqueous system containing pea protein and maltodextrins was followed under thermodynamic incompatibility conditions. Firstly, the phase diagram of the system was established. Then, the partition of aroma compounds between the phase rich in protein and the phase rich in maltodextrin was measured by SPME–GC–MS. There was a transfer of volatile compounds during phase separation. Variations of pH were also used to vary the retention of volatile compounds by p…
Produzione di esopolisaccaridi da Sphingomonas spp.
2006
El antiguo Hospital de la Caridad e iglesia aneja de Nuestra Señora de los Dolores, de Yecla (Murcia): Mecenazgo, espacio arquitectónica y patrimonio…
2011
Estudio de la función inmunitaria en pacientes esquizofrénicos y bipolares tipo I
2007
RESUMEN El estudio de la función inmunitaria en los pacientes psicóticos ha adquirido un protagonismo creciente, como consecuencia del avance en los conocimientos acerca de las implicaciones del sistema inmune en el funcionamiento del sistema nervioso y de recientes descubrimientos sobre anomalías de la función inmunitaria en pacientes psicóticos. En la actualidad se conoce la interrelación entre sistema nervioso, sistema inmune y conducta, y gracias a esta comunicación se facilita una respuesta integrada del organismo, cuyo fin sería el mantenimiento de la homeostasis. Estos hechos han llevado al planteamiento de estrategias de investigación multidisciplinaria, dando lugar a la aparición d…