Search results for "Array"

Solution Processed Micro- and Nano-Bioarrays for Multiplexed Biosensing

2012

This Feature article reports on solution dispensing methodologies which enable the realization of multiplexed arrays at the micro- and nanoscale for relevant biosensing applications such as drug screening or cellular chips.

A Java-based Wrapper for Wireless Communications

2008

The increasing number of new applications for mobile devices in pervasive environments, do not cope with changes in the wireless communications. Developers of such applications have to deal with problems arising from the available wireless connections in the given environment. A middleware is a solution that allows to overcome some of these problems. It provides to the applications a set of functions that facilitate their development. In this paper we present a Java-based communication wrapper, called SmartTraffic, which allows programmers to seamlessly use TCP or UDP protocols over Bluetooth or any IP-based wireless network. Developers can use SmartTraffic within their Java applications, t…

Biometric sensors rapid prototyping on field-programmable gate arrays

2015

AbstractBiometric user authentication in large-scale distributed systems involves passive scanners and networked workstations and databases for user data acquisition, processing, and encryption. Unfortunately, traditional biometric authentication systems are prone to several attacks, such as Replay Attacks, Communication Attacks, and Database Attacks. Embedded biometric sensors overcome security limits of conventional software recognition systems, hiding its common attack points. The availability of mature reconfigurable hardware technology, such as field-programmable gate arrays, allows the developers to design and prototype the whole embedded biometric sensors. In this work, two strong an…

Bayesian network based pathway analysis of microarray data

2011

Cytogenetic analysis and metabolic profiling reveal a subgroup of benign meningiomas with chromosomal instabilities and aggressive metabolism

2010

Meningiomas add up to 30% of Central Nervous System (CNS) tumours. Atypical meningiomas show a high index of recurrence 5 years after complete resection. Sometimes, meningiomas with histological diagnosis of benign meningioma show genetics characteristics of atypical meningioma. Aberrations of chromosomes 1, 14, and 22 are the most frequently reported abnormalities in meningiomas. In this communication we used cytogenetic, FISH, and NMR metabolic profiling for a molecular characterization of a series of 46 meningiomas. Tumor samples were obtained from 46 patients with meningioma (36 benign and 12 atypical) from the Clinic Hospital of Valencia. Cytogenetic analyses were performed by short-te…

Oridonin Targets Multiple Drug-Resistant Tumor Cells as Determined by in Silico and in Vitro Analyses

2018

Drug resistance is one of the main reasons of chemotherapy failure. Therefore, overcoming drug resistance is an invaluable approach to identify novel anticancer drugs that have the potential to bypass or overcome resistance to established drugs and to substantially increase life span of cancer patients for effective chemotherapy. Oridonin is a cytotoxic diterpenoid isolated from Rabdosia rubescens with in vivo anticancer activity. In the present study, we evaluated the cytotoxicity of oridonin toward a panel of drug-resistant cancer cells overexpressing ABCB1, ABCG2, or ΔEGFR or with a knockout deletion of TP53. Interestingly, oridonin revealed lower degree of resistance than the control dr…

The THESEUS space mission concept: science case, design and expected performances

2018

THESEUS is a space mission concept aimed at exploiting Gamma-Ray Bursts for investigating the early Universe and at providing a substantial advancement of multi-messenger and time-domain astrophysics. These goals will be achieved through a unique combination of instruments allowing GRB and X-ray transient detection over a broad field of view (more than 1sr) with 0.5¿1 arcmin localization, an energy band extending from several MeV down to 0.3¿keV and high sensitivity to transient sources in the soft X-ray domain, as well as on-board prompt (few minutes) follow-up with a 0.7¿m class IR telescope with both imaging and spectroscopic capabilities. THESEUS will be perfectly suited for addressing …

Design and implementation of an embedded coprocessor with native support for 5D, quadruple-based Clifford algebra

2013

Geometric or Clifford algebra (CA) is a powerful mathematical tool that offers a natural and intuitive way to model geometric facts in a number of research fields, such as robotics, machine vision, and computer graphics. Operating in higher dimensional spaces, its practical use is hindered, however, by a significant computational cost, only partially addressed by dedicated software libraries and hardware/software codesigns. For low-dimensional algebras, several dedicated hardware accelerators and coprocessing architectures have been already proposed in the literature. This paper introduces the architecture of CliffordALU5, an embedded coprocessing core conceived for native execution of up t…

Cardio-facio-cutaneous syndrome and gastrointestinal defects: report on a newborn with 19p13.3 deletion including the MAP 2 K2 gene

2022

Abstract Background Cardio-facio-cutaneous syndrome (CFCS) belongs to RASopathies, a group of conditions caused by mutations in genes encoding proteins of the rat sarcoma/mitogen-activated protein kinase (RAS/MAPK) pathway. It is a rare syndrome, with about 300 patients reported. Main clinical manifestations include facial dysmorphisms, growth failure, heart defects, developmental delay, and ectodermal abnormalities. Mutations (mainly missense) of four genes (BRAF, MAP 2 K1, MAP 2 K2, and KRAS) have been associated to CFCS. However, whole gene deletions/duplications and chromosomal microdeletions have been also reported. Specifically, 19p13.3 deletion including MAP 2 K2 gene are responsible…

Archaeological excavation confirms the geophysical anomalies recorded at the cathedral of tarragona - A comparative study

2011

An integrated geophysical survey was conducted in September 2007 at the Cathedral of Tarragona to search for archaeological remains of the Roman temple dedicated to the Emperor Augustus. Many hypotheses about its location have been put forward, the most recent ones suggesting it could be inside the present cathedral. A project including Electrical resistivity tomography (ERT) and Ground probing radar (GPR) was planned for a year and conducted during a week of intensive field survey. Both ERT and GPR provided detailed information about subsoil structures. Different ERT techniques and arrays were used, ranging from standard Wenner-Schlumberger 2D sections to full 3D electrical imaging using t…