Search results for "Arrow"
showing 10 items of 953 documents
Interleukins
1994
With interleukins (IL), a new class of potential drugs has been introduced into clinical research. These signal peptides are involved in the regulation of many physiological and pathophysiological processes. IL-1, -2, -3, -4, -6 and -11 have been tested in clinical trials. The growth promoting, growth inhibiting or immunomodulatory activities of interleukins represent the theoretical basis for large scale clinical testing, predominantly in malignant disease. Dose-dependent effects on numbers of peripheral blood cells and recovery from bone marrow failure have been demonstrated for IL-1, -3, -6 and -11. Phase III trials are in progress to determine their value for clinical practice. However,…
New emerging potentials for human Wharton's jelly mesenchymal stem cells: immunological features and hepatocyte-like differentiative capacity.
2010
In recent years, human mesenchymal stem cells (MSC) have been extensively studied. Their key characteristics of long-term self-renewal and a capacity to differentiate into diverse mature tissues favour their use in regenerative medicine applications. Stem cells can be found in embryonic and extra-embryonic tissues as well as in adult organs. Several reports indicate that cells of Wharton's jelly (WJ), the main component of umbilical cord extracellular matrix, are multipotent stem cells, expressing markers of bone marrow mesenchymal stem cells (BM-MSC), and giving rise to different cellular types of both connective and nervous tissues. Wharton's jelly mesenchymal stem cells (WJ-MSC) express …
Cloning and characterization of the peroxisomal acyl CoA oxidaseACO3 gene from the alkane-utilizing yeastYarrowia lipolytica
1998
The ACO3 gene, which encodes one of the acyl-CoA oxidase isoenzymes, was isolated from the alkane-utilizing yeast Yarrowia lipolytica as a 10 kb genomic fragment. It was sequenced and found to encode a 701-amino acid protein very similar to other ACOs, 67.5% identical to Y. lipolytica Aco1p and about 40% identical to S. cerevisiae Pox1p. Haploid strains with a disrupted allele were able to grow on fatty acids. The levels of acyl-CoA oxidase activity in the ACO3 deleted strain, in an ACO1 deleted strain and in the wild-type strain, suggested that ACO3 encodes a short chain acyl-CoA oxidase isoenzyme. This narrow substrate spectrum was confirmed by expression of Aco3p in E. coli.
Doppler Shift Characterization of Wideband Mobile Radio Channels
2019
The prevailing approach for characterizing the Doppler shift (DS) of mobile radio channels assumes the transmission of an unmodulated carrier. This consideration is valid for the analysis of narrowband channels, but its pertinence is questionable in regards to the modeling of wideband channels. In this correspondence, we redefine the DS from a time-frequency analysis perspective that does not depend on the aforementioned assumption. We systematically demonstrate that the DS can be characterized by the instantaneous frequency of the channel transfer function. This generic definition makes evident a fundamental aspect of the DS that is seldom acknowledged, namely, the DS is a frequency-varyin…
An Ergodic Sum-of-Cisoids Simulator for Multiple Uncorrelated Rayleigh Fading Channels Under Generalized Scattering Conditions
2012
In this paper, we present a new method for the design of ergodic sum-of-sinusoids (SOS) simulators for multiple uncorrelated narrowband Rayleigh fading channels. The method, which is intended for a special class of SOS models known as sum-of-cisoids (SOC) models, enables the generation of an unlimited number of mutually uncorrelated Rayleigh fading waveforms with specified autocorrelation properties. This is in contrast to all known methods proposed for SOS simulators, which are restricted to the simulation of multiple uncorrelated Rayleigh fading channels characterized by autocorrelation functions (ACFs) derived under the isotropic scattering assumption. The excellent performance of this n…
The generalized method of equal areas for the design of sum-of-cisoids simulators for mobile Rayleigh fading channels with arbitrary Doppler spectra
2011
We present in this paper a generalized version of the method of equal areas (MEA) that is well suited for the design of sum-of-cisoids (SOC) simulators for narrowband mobile Rayleigh fading channels characterized by any type of Doppler power spectral densities (DPSDs). Unlike the original MEA, the generalized MEA (GMEA) can be applied to the simulation of fading channels with asymmetrical DPSDs. This is an important feature because the simulation of such channels is of great interest for the laboratory analysis of mobile communication systems under non-isotropic scattering conditions. We show that irrespective of the underlying DPSD, the GMEA results in a very good approximation to the auto…
A new low cost power line communication solution for smart grid monitoring and management
2018
Modern smart grids require the improvement of measurement and communication infrastructures of distribution networks, at both medium voltage (MV) and low voltage (LV) levels. Distributed sensing and measurement systems are needed to provide all necessary data for grid monitoring, control and management, as well as for the implementation of a number of smart functionalities, such as remote control of distributed generators (DGs), real time analysis of power flows, automatic meter reading (AMR), demand side management (DSM), grid automation and so on [1]-[6]. Acquired network data include typical electrical network quantities and status variables (such as powers, voltages, currents, switches …
Entropy-Based Classifier Enhancement to Handle Imbalanced Class Problem
2017
The paper presents a possible enhancement of entropy-based classifiers to handle problems, caused by the class imbalance in the original dataset. The proposed method was tested on synthetic data in order to analyse its robustness in the controlled environment with different class proportions. As also the proposed method was tested on the real medical data with imbalanced classes and compared to the original classification algorithm results. The medical field was chosen for testing due to frequent situations with uneven class ratios.
Are nonlinear model-free conditional entropy approaches for the assessment of cardiac control complexity superior to the linear model-based one?
2016
Objective : We test the hypothesis that the linear model-based (MB) approach for the estimation of conditional entropy (CE) can be utilized to assess the complexity of the cardiac control in healthy individuals. Methods : An MB estimate of CE was tested in an experimental protocol (i.e., the graded head-up tilt) known to produce a gradual decrease of cardiac control complexity as a result of the progressive vagal withdrawal and concomitant sympathetic activation. The MB approach was compared with traditionally exploited nonlinear model-free (MF) techniques such as corrected approximate entropy, sample entropy, corrected CE, two k -nearest-neighbor CE procedures and permutation CE. Electroca…
Characterization of entropy measures against data loss: Application to EEG records
2012
This study is aimed at characterizing three signal entropy measures, Approximate Entropy (ApEn), Sample Entropy (SampEn) and Multiscale Entropy (MSE) over real EEG signals when a number of samples are randomly lost due to, for example, wireless data transmission. The experimental EEG database comprises two main signal groups: control EEGs and epileptic EEGs. Results show that both SampEn and ApEn enable a clear distinction between control and epileptic signals, but SampEn shows a more robust performance over a wide range of sample loss ratios. MSE exhibits a poor behavior for ratios over a 40% of sample loss. The EEG non-stationary and random trends are kept even when a great number of samp…