Search results for "Arrow"
showing 10 items of 953 documents
"Table 6" of "Search for pairs of highly collimated photon-jets in $pp$ collisions at $\sqrt{s}$ = 13 TeV with the ATLAS detector"
2018
The expected upper limits on the production cross-section times the product of branching ratios for the benchmark signal scenario involving a scalar particle $X$ with narrow width decaying via $X\rightarrow aa\rightarrow 6\pi^0$, $\sigma_X\times B(X\rightarrow aa)\times B(a\rightarrow 3\pi^0)^2$. The limits for $m_{a}$ = 5 GeV and 10 GeV do not cover as large a range as the other mass points, since the region of interest is limited to $ m_{a} < 0.01 \times m_{X}$. Additionally, the expected limits are not provided for a small number of points, indicated with a hyphen, because of a technical failure with the computation.
"Table 5" of "Search for pairs of highly collimated photon-jets in $pp$ collisions at $\sqrt{s}$ = 13 TeV with the ATLAS detector"
2018
The observed upper limits on the production cross-section times the product of branching ratios for the benchmark signal scenario involving a scalar particle $X$ with narrow width decaying via $X\rightarrow aa\rightarrow 6\pi^0$, $\sigma_X\times B(X\rightarrow aa)\times B(a\rightarrow 3\pi^0)^2$. The limits for $m_{a}$ = 5 GeV and 10 GeV do not cover as large a range as the other mass points, since the region of interest is limited to $ m_{a} < 0.01 \times m_{X}$.
"Table 4" of "Search for pairs of highly collimated photon-jets in $pp$ collisions at $\sqrt{s}$ = 13 TeV with the ATLAS detector"
2018
The expected upper limits on the production cross-section times the product of branching ratios for the benchmark signal scenario involving a scalar particle $X$ with narrow width decaying via $X\rightarrow aa\rightarrow 4\gamma$, $\sigma_X\times B(X\rightarrow aa)\times B(a\rightarrow\gamma\gamma)^2$. The limits for $m_{a}$ = 5 GeV and 10 GeV do not cover as large a range as the other mass points, since the region of interest is limited to $ m_{a} < 0.01 \times m_{X}$. Additionally, the expected limits are not provided for a small number of points, indicated with a hyphen, because of a technical failure with the computation.
Hematopoietins: New Tools in the Treatment of Hematopoietic Insufficiency
1993
The number of circulating blood cells and their function are regulated by a variety of peptide hormones, the so-called hematopoietic growth factors (HGFs) or hematopoietins. In a complex regulatory network of stimulating and inhibiting peptide hormones [1], the number of circulating blood cells is kept at a physiological level. Because many of these blood cells have a relatively short half-life, the bone marrow is in a state of constant active proliferation in order to produce the necessary blood cells. For instance, granulocytes are made at a rate of 5 × 107–10 × 107 cells/s. It is unclear whether additional, hematopoietin-independent regulatory mechanisms exist, which might be responsible…
The efficient bovine insulin presentation capacity of bone marrow-derived macrophages activated by granulocyte-macrophage colony-stimulating factor c…
1993
Bone marrow-derived macrophages (BMM phi) were shown before to function as antigen-presenting cells. We show here, that the antigen presentation capacity of BMM phi depends on the nature of the antigen and is differently regulated by the lymphokines interferon-gamma (IFN-gamma) and granulocyte/macrophage-colony-stimulating factor (GM-CSF). When bovine insulin (BI) was employed as antigen, only BMM phi treated with GM-CSF (GM-CSF-M phi) were efficient presenters, but when presentation of the antigens ovalbumin and conalbumin was tested, IFN-gamma-pulsed BMM phi (IFN-gamma-M phi) proved superior to GM-CSF-M phi. The lack of efficient BI presentation function of IFN-gamma-M phi was only obviou…
Intracellular pH-dependent efflux of the fluorescent probe pyranine in the yeast Yarrowia lipolytica.
2001
International audience; 8-Hydroxypyrene-1,3,6-trisulfonic acid (pyranine) can be used as a vital intracellular pH (pH(i)) indicator. In the yeast Yarrowia lipolytica, a partial efflux of the probe was detected by using the pH-independent wavelength of 415 nm. A simplified correction of the fluorescent signals was applied, enabling to show for this species a good near-neutral pH(i) maintenance capacity in a pH 3.9 medium. Octanoic acid, which is known to have toxic effects on yeast, decreased the pH(i) and increased the 260-nm-absorbing compounds leakage. However, this acid inhibited the fluorescent probe efflux linearly with its concentration suggesting a pH(i)-dependent efflux of pyranine …
High Expression of Cannabinoid Receptor 2 on Cytokine-Induced Killer Cells and Multiple Myeloma Cells
2020
Multiple myeloma (MM) is characterized by aberrant bone marrow plasma cell (PC) proliferation and is one of the most common hematological malignancies. The potential effect of cannabinoids on the immune system and hematological malignancies has been poorly characterized. Cannabidiol (CBD) may be used to treat various diseases. CBD is known to exert immunomodulatory effects through the activation of cannabinoid receptor 2 (CB2), which is expressed in high levels in the hematopoietic system. Cytokine-induced killer (CIK) cells are a heterogeneous population of polyclonal T lymphocytes obtained via ex vivo sequential incubation of peripheral blood mononuclear cells (PBMCs) with interferon-&gam…
Dendritic cells trigger tumor cell death by a nitric oxide-dependent mechanism.
2007
Abstract Dendritic cells (DCs) are well known for their capacity to induce adaptive antitumor immune response through Ag presentation and tumor-specific T cell activation. Recent findings reveal that besides this role, DCs may display additional antitumor effects. In this study, we provide evidence that LPS- or IFN-γ-activated rat bone marrow-derived dendritic cells (BMDCs) display killing properties against tumor cells. These cytotoxic BMDCs exhibit a mature DC phenotype, produce high amounts of IL-12, IL-6, and TNF-α, and retain their phagocytic properties. BMDC-mediated tumor cell killing requires cell-cell contact and depends on NO production, but not on perforin/granzyme or on death re…
P-selectin glycoprotein ligand-1 as a potential target for humoral immunotherapy of multiple myeloma.
2008
Monoclonal antibodies (mAbs), successfully adopted in the treatment of several haematological malignancies, have proved almost ineffective in multiple myeloma (MM), because of the lack of an appropriate antigen for targeting and killing MM cells. Here, we demonstrate that PSGL1, the major ligand of P-Selectin, a marker of plasmacytic differentiation expressed at high levels on normal and neoplastic plasma cells, may represent a novel target for mAb-mediated MM immunotherapy. The primary effectors of mAb-induced cell-death, complement-mediated lysis (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC), were investigated using U266B1 and LP1 cell-lines as models. Along with immunolo…
T cell-mediated cytotoxic immune responsiveness of chimeric mice bearing a thymus graft fully allogeneic to the graft of lymphoid stem cells
1980
Fully allogeneic, chimeric mice were established by adult thymectomy of (A × B) F1animals, grafting parental A-type thymus under the kidney capsula, followed by lethal (900 rd) irradiation and reconstitution with B parental-type bone marrow cells treated with xenogeneic anti-T cell antiserum plus complement. Following in vivo sensitization with inactivated Sendai virus (SV) suspensions, no virus-specific T cells could be detected within the spleen cells of the mice. Upon stimulation with third-party allogeneic cells in a primary mixed lymphocyte culture, spleen cells of all animals generated alloreactive cytotoxic T lymphocytes (CTL). More interestingly, upon secondary in vitro stimulation …