Search results for "Arrow"
showing 10 items of 953 documents
CD8 T-Cell Immunotherapy of Cytomegalovirus Disease in the Murine Model
2010
Publisher Summary Cytomegaloviruses (CMVs) are conditional pathogens that are strictly species specific and are usually well controlled in their respective mammalian hosts by the effector mechanisms of both innate and adaptive immunity. Human CMV (hCMV) is mostly acquired perinatally as well as in early childhood and is transmitted, for instance, through breast milk and saliva. Whilst the immune response in an immunocompetent host prevents an overt CMV disease and rapidly terminates the productive acute infection, viral genome is maintained in most tissues for the life span of the infected host in a state known as viral latency. Latency implies that infectious virions are no longer produced…
Recent Advances in Derivation of Functional Hepatocytes from Placental Stem Cells
2013
Abstract: End-stage liver diseases are one of the leading causes of death in the world. Often orthotopic liver transplantation represents the final therapeutic choice. The limits of this approach are the scarcity of donor livers available, and the many side effects related to the administration of immune suppressants to the patients. Cellular therapy for liver diseases is increasingly being viewed as a promising strategy to provide hepatocytes to replenish the parenchymal cells of the organ. This technique suffers of some important limitations, such as the difficulty in isolating sufficient cell numbers (e.g. when adult or foetal hepatocytes are used for transplantation), the limited viabil…
Gamma-delta T-cell lymphomas.
2009
Peripheral T-cell lymphomas (TCLs) are uncommon neoplasms, accounting for about 12% of all lymphoid tumors worldwide. TCLs in which gammadelta T-cell receptors are expressed (gammadelta TCLs) are extremely aggressive and rare (<1% of lymphoid neoplasms). gammadelta TCLs originate from gammadelta T cells, a small subset of peripheral T cells with direct antigen recognition capability acting at the interface between innate and adaptive immunity. Two distinct gammadelta TCL entities are recognized: hepatosplenic T-cell lymphoma (HSTL) and primary cutaneous gammadelta T-cell lymphoma (PCGD-TCL). HSTL is a well-characterized extranodal lymphoma that has a disguised onset, secondary to intrasinus…
Polymerase chain reaction in the diagnosis and prognosis of Mediterranean visceral leishmaniasis in immunocompetent children.
2002
Objective. To assess the usefulness of a polymerase chain reaction (PCR) assay amplifying the small subunit rRNA coding region of Leishmania species performed on peripheral blood (PB) and bone marrow (BM) aspirates for the diagnosis and follow-up of visceral leishmaniasis (VL) in children living in the Mediterranean basin. Design. A prospective study was conducted on children consecutively hospitalized over a 1-year period at our Infectious Diseases Department in Sicily (Italy) presenting with fever, hepatosplenomegaly, and/or pancytopenia and a positive Leishmania serology (≥1:40). Results. Among the 14 patients hospitalized with signs and symptoms suggestive of the disease and a positive …
Aportaciones hidrogeológicas al estudio arqueológico de los orígenes de la Edad del Bronce de La Mancha: la cueva monumentalizada de Castillejo del B…
2014
Estudios recientes indican que las motillas, asentamientos de la Edad del Bronce de La Mancha, pudieron ser las más antiguas captaciones de agua subterránea en la Península Ibérica. Pero ¿por qué no existen motillas en el Campo de Montiel, territorio ubicado tradicionalmente en esta área cultural? En Castillejo del Bonete, sitio arqueológico situado en esa comarca, existe una cueva que fue utilizada y sellada durante la Prehistoria Reciente. Se presenta ahora la primera investigación paleohidrogeológica interdisciplinar en La Mancha, que ha analizado manantiales y niveles de agua subterránea del acuífero de Campo de Montiel, así como el interior de la sima de Castillejo del Bonete. Las conc…
"Table 44" of "Search for long-lived particles produced in $pp$ collisions at $\sqrt{s}=13$ TeV that decay into displaced hadronic jets in the ATLAS …
2018
Endcap MS vertex efficiencies (in %) for baryogenesis $\chi \rightarrow \tau\tau\nu$ benchmark samples ($m_{h}=125$ GeV). The vertex reconstruction efficiency is defined as the fraction of simulated LLP decays in the MS fiducial volume that match a reconstructed vertex ($\Delta R(\textrm{LLP,vertex}) = 0.4$) passing the baseline event selection and satisfying the vertex isolation criteria. A vertex is considered matched to a displaced decay if the vertex is within $\Delta R = 0.4$ of the simulated decay position. The MS vertex efficiency is parameterized as a function of the LLP decay position.
Entropy Production during Asymptotically Safe Inflation
2011
The Asymptotic Safety scenario predicts that the deep ultraviolet of Quantum Einstein Gravity is governed by a nontrivial renormalization group fixed point. Analyzing its implications for cosmology using renormalization group improved Einstein equations we find that it can give rise to a phase of inflationary expansion in the early Universe. Inflation is a pure quantum effect here and requires no inflaton field. It is driven by the cosmological constant and ends automatically when the renormalization group evolution has reduced the vacuum energy to the level of the matter energy density. The quantum gravity effects also provide a natural mechanism for the generation of entropy. It could eas…
Computing black hole entropy in loop quantum gravity from a conformal field theory perspective
2009
Motivated by the analogy proposed by Witten between Chern-Simons and conformal field theories, we explore an alternative way of computing the entropy of a black hole starting from the isolated horizon framework in loop quantum gravity. The consistency of the result opens a window for the interplay between conformal field theory and the description of black holes in loop quantum gravity.
Quantum walk on a cylinder
2016
We consider the 2D alternate quantum walk on a cylinder. We concentrate on the study of the motion along the open dimension, in the spirit of looking at the closed coordinate as a small or "hidden" extra dimension. If one starts from localized initial conditions on the lattice, the dynamics of the quantum walk that is obtained after tracing out the small dimension shows the contribution of several components, which can be understood from the study of the dispersion relations for this problem. In fact, these components originate from the contribution of the possible values of the quasi-momentum in the closed dimension. In the continuous space-time limit, the different components manifest as …
Robotic transanal total mesorectal excision: Is the future now?
2021
Total mesorectal excision (TME) is the standard surgical treatment for the curative radical resection of rectal cancers. Minimally invasive TME has been gaining ground favored by the continuous technological advancements. New procedures, such as transanal TME (TaTME), have been introduced to overcome some technical limitations, especially in low rectal tumors, obese patients, and/or narrow pelvis. The earliest TaTME reports showed promising results when compared with the conventional laparoscopic TME. However, recent publications raised concerns regarding the high rates of anastomotic leaks or local recurrences observed in national series. Robotic TaTME (R-TaTME) has been proposed as a nove…