Search results for "Arrow"
showing 10 items of 953 documents
Bone marrow-derived progenitors are greatly reduced in patients with severe COPD and low-BMI.
2009
Chronic obstructive pulmonary disease (COPD) patients have reduced circulating hemopoietic progenitors. We hypothesized that severity of COPD parallels the decrease in progenitors and that the reduction in body mass index (BMI) could be associated with more severe bone marrow dysfunction. We studied 39 patients with moderate to very severe COPD (18 with low-BMI and 21 with normal-BMI) and 12 controls. Disease severity was associated to a greater reduction in circulating progenitors. Proangiogenetic and inflammatory markers correlated with disease severity parameters. Compared to normal-BMI patients, low-BMI patients showed: greater reduction in circulating progenitors; higher VEGF-A, VEGF-C…
Asymptomatic Amyloidosis at the Time of Diagnostic Bone Marrow Biopsy in Newly Diagnosed Patients with Multiple Myeloma and Smoldering Multiple Myelo…
2009
Abstract Abstract 2803 Poster Board II-779 Background. The rate of asymptomatic amyloidosis (asym-amyloidosis) detected in patients with newly diagnosed multiple myeloma (MM) or smoldering multiple myeloma (SMM) is unknown. This topic is significant because unrecognized AL may be associated with increased mortality may change the patient's management. The objective of the present investigation was to evaluate the number and clinical significance of asym-amyloidosis in MM and SM patients at the time of the diagnostic bone marrow (BM) biopsy for MM. Materials and Methods. The study population was selected from the Mayo Clinic Dysproteinemia database and consisted of consecutive patients with …
Relapse risk after autologous transplantation in patients with newly diagnosed myeloma is not related with infused tumor cell load and the outcome is…
2006
BACKGROUND AND OBJECTIVES: This European Group for Blood and Marrow Transplantation (EBMT) multicentre randomized phase III study was designed to assess the safety and efficacy of CD34+ selection in newly diagnosed myeloma patients undergoing autologous transplantation. DESIGN AND METHODS: One hundred and eleven patients responsive to initial chemotherapy were randomized to receive CD34+ selected (arm A) or unselected PBPC (arm B) after conditioning with high-dose melphalan and TBI. ASO-PCR was used to assess purging efficacy and reinfused tumor load. Tumor load could be assessed in 59 patients. RESULTS: CD34+ selection gave a median tumor cell depletion of 2.2 logs (0.77-5.96). No tumor ce…
Predator proximity as a stressor in breeding flycatchers: mass loss, stress protein induction, and elevated provisioning.
2010
We investigated the physiological and behavioral consequences for prey breeding at different distances from a nesting predator. In a natural setting, Pied Flycatchers (Ficedula hypoleuca) made territory location decisions relative to established Sparrowhawk (Accipiter nisus) nests. From female flycatchers attending nests at different distances from Sparrowhawk nests, we measured body mass, blood stress protein (HSP60 and HSP70), and plasma immunoglobulin levels at the beginning (initial) and end (final) of the flycatcher breeding cycle, and provisioning rates during the nestling phase. We found that individuals breeding in closer proximity to Sparrowhawk nests, under higher perceived predat…
A singleFKShomologue inYarrowia lipolyticais essential for viability
2002
The synthesis of β-1,3-glucan, the structural component of the yeast cell wall which gives shape to the cell, occurs at the plasma membrane and is the result of the activity of at least a two-component complex. Fks1p is the catalytic subunit directly responsible for the synthesis of β-1,3-glucan, whilst the second subunit, Rho1p, has a GTP-dependent regulatory role. FKS1 has been characterized in Saccharomyces cerevisiae, where its function is at least partially redundant with that of FKS2/GSC2. FKS homologues have also been identified in several other fungal species, including Candida albicans, Schizosaccharomyces pombe, Aspergillus nidulans, Cryptococcus neoformans and Paracoccidiodes bra…
Inhibition of Lymphocyte Proliferation during Parasitic Infection with Nippostrongylus Brasiliensis
1979
It is now well established that parasitic infections can lead to the production of high titers of IgE anti parasitic antibodies in experimental animals and in man (1,2). One of the best studied experimental systems involves the ability of the nematode parasite Nippostrongylus brasiliensis (N.B.) to stimulate a high titer reaginic antibody response to worm antigens in the rat. These studies were extended by the reports of Orr and Blair that parasitic infections can cause non specific proliferation of IgE antibody response against antigens unrelated to those of the parasite (3). The amplification of an already existing IgE antibody response can be induced before infection by inoculating the a…
Monoclonal Gammopathies and the Bone Marrow Microenvironment: From Bench to Bedside and Then Back Again
2023
Multiple myeloma (MM) is an incurable hematologic malignancy characterized by a multistep evolutionary pathway, with an initial phase called monoclonal gammopathy of undetermined significance (MGUS), potentially evolving into the symptomatic disease, often preceded by an intermediate phase called “smoldering” MM (sMM). From a biological point of view, genomic alterations (translocations/deletions/mutations) are already present at the MGUS phase, thus rendering their role in disease evolution questionable. On the other hand, we currently know that changes in the bone marrow microenvironment (TME) could play a key role in MM evolution through a progressive shift towards a pro-inflammatory and…
Regenerative Capacity of Adipose Derived Stem Cells (ADSCs), Comparison with Mesenchymal Stem Cells (MSCs).
2019
Adipose tissue is now on the top one of stem cell sources regarding its accessibility, abundance, and less painful collection procedure when compared to other sources. The adipose derived stem cells (ADSCs) that it contains can be maintained and expanded in culture for long periods of time without losing their differentiation capacity, leading to large cell quantities being increasingly used in cell therapy purposes. Many reports showed that ADSCs-based cell therapy products demonstrated optimal efficacy and efficiency in some clinical indications for both autologous and allogeneic purposes, hence becoming considered as potential tools for replacing, repairing, and regenerating dead or dama…
Identification and characterization of the somatic stem cell niche in the human endometrium
2013
El endometrio es la capa de mucosa que recubre el interior del útero y consiste en un epitelio simple cilíndrico con o sin cilios, glándulas y un estroma rico en tejido conjuntivo y altamente vascularizado. Durante cada ciclo menstrual, el endometrio sufre una serie de cambios en respuesta a fluctuaciones en los niveles de las hormonas esteroideas procedentes del ovario. El endometrio se divide histológicamente en dos capas, la capa basal, la cual ni responde a las hormonas esteroideas ni sufre descamación, pudiendo regenerar una nueva capa funcional en el siguiente ciclo menstrual. Mientras que la capa funcional si responde tanto a la progesterona como el estradiol, descamándose durante la…
Kaulu smadzenu mononukleāro šūnu daudzumuun kvalitātiietekmējošie faktori cela locītavas osteoartrīta pacientiem
2020
Osteoartrīts ir visizplatītākā locītavu slimība ar ievērojamām ekonomiskām izmaksām un pieaugošu izplatību (Conaghan et al. 2014). Viena no galvenajām problēmām ir tā, ka nav nekādas ārstēšanas, izņemot locītavas aizvietošanu, kas var izārstēt osteoartrītu, tāpēc ir svarīgi izpētīt alternatīvas ārstēšanas metodes, piemēram, cilmes šūnu terapiju. Interese par mononukleāro šūnu izpēti kā ārstēšanas metodi ir plaši pieaugusi, bet vēl tikai nedaudz ir zināms par optimālo ievadīto mononukleāro šūnu daudzumu un par to, kāpēc mononukleāro un mezenhimālo cilmes šūnu daudzums un kvalitāte cilvēkiem ir atšķirīga. Pētījuma mērķis ir noskaidrot, vai starp pacientu faktoriem, piemēram, vecumu, dzimumu, …