Search results for "Atypical"
showing 10 items of 111 documents
Biochemical evidence that the atypical antipsychotic drugs clozapine and risperidone block 5-HT(2C) receptors in vivo.
2002
Clozapine and risperidone are two atypical antipsychotic drugs which bind, among other receptors, to 5-HT(2C) receptor subtypes. They inhibit the basal inositol phosphate production in mammalian cells expressing rat or human 5-HT(2C) receptors. This biochemical effect is indicative of inverse agonist activity at these receptors. There is evidence that 5-HT(2C) receptors are involved in the control of the activity of central dopaminergic system. Therefore, the effects of clozapine (5 mg/kg ip), risperidone (0.08 mg/kg ip) and of the typical antipsychotic haloperidol (0.1 mg/kg ip) were studied on the extracellular concentration of dopamine (DA) in the nucleus accumbens of chloral hydrate-ane…
Epileptic seizures as a manifestation of cow's milk allergy: a studied relationship and description of our pediatric experience
2014
Adverse reactions after ingestion of cow's milk proteins can occur at any age, from birth and even amongst exclusively breast-fed infants, although not all of these are hypersensitivity reactions. The most common presentations related to cow's milk protein allergy are skin reactions, failure to thrive, anaphylaxis as well as gastrointestinal and respiratory disorders. In addition, several cases of cow's milk protein allergy in the literature have documented neurological involvement, manifesting with convulsive seizures in children. This may be due to CNS spread of a peripheral inflammatory response. Furthermore, there is evidence that pro-inflammatory cytokines are responsible for disruptin…
An execution in medieval Sicily: Computerised tomography scan analysis and 3D reconstruction of an ancient forensic context
2019
The bioarchaeological and forensic approach is increasingly applied in the study of funerary contexts in archaeology. Here, we present a case of an atypical medieval burial recently discovered in Piazza Armerina (Sicily), in which the integrated use of traditional bioarchaeological and forensic anthropology methods was crucial. The skeleton was lying in a prone position and was characterised by a peculiar injury pattern. We recorded six clear stab wound marks on the posterior surface of the sternum. The use of computerised tomography scan and 3D modelling techniques has made it possible to obtain a reliable reconstruction of the cause and modality of death, pointing to the execution of the …
Retour en formation et parcours d'études atypiques : déterminants et valorisation sur le marché du travail
2019
Life long learning appears as a major concern for our societies. After leaving the educational system, learning can imply returning to school or continuing education. Academic careers in France seem less and less linear. Young peopleare encouraged to make the most of college breaks in order to diversify their experiences. During their career, they are to be trained to « be free to choose their professional future », as mentions a new law. This thesis, then, aims atidentifying the reasons why people go back to training and at stuying how such returns are seen by the labor market.This work includes a preliminary chapter and three other chapters, each with specific data. Based on a literature …
Palatal atypical histiocytic granuloma
2009
In this report, we examine a clinical entity called atypical histiocytic granuloma (AHG), which is characterized by ulceroproliferative lesions that clinically simulate a squamous cell carcinoma or specific granulomatous lesions. AHG histologically shows a histiocytic proliferation and is characterized by specific mitotic activity, which has the potential to be confused with malignant processes of a lymphoid origin. There are few cases reported in the literature, and an adequateknowledge of the process is required in order to avoid a misdiagnosis, especially as regards malignant processes. To our knowledge, a case of this type of lesion in the palate has not yet been described. We present a…
A case-control evaluation of sensory profile among preschool children affected by autism spectrum disorder
2019
Background: Autism spectrum disorders (ASD) are neurobehavioral syndromes caused by a developmental disorder, biologically determined, with a very early onset and deficit mainly related to social communication and interaction.There is a considerable amount of literature on ASD suggesting abnormal sensory experience as a basic symptom, as also reported by the DSM-5 and ICD-10.The current case-control study aimed to investigate the sensory perception skills in preschool children affected by ASD compared with a control group of typical developing children.Materials and methods: The study sample was composed of 42 children, subdivided into two groups: 21 ASD (12 males); 21 typical developing (T…
Unrecognised cardiovascular disease in type 2 diabetes: is it time to act earlier?
2018
Abstract Cardiovascular disease (CVD) is the most significant prognostic factor in individuals with type 2 diabetes (T2D). However, a significant number of individuals may develop CVD that does not present with the classic angina-related or heart failure symptoms. In these cases, CVD may seem to be ‘silent’ or ‘asymptomatic’, but may be more accurately characterised as unrecognised diabetic cardiac impairment. An initial step to raise awareness of unrecognised CVD in individuals with T2D would be to reach a consensus regarding the terminology used to describe this phenomenon. By standardising the terminologies, and agreeing on the implementation of an efficient screening program, it is anti…
Platelets Contribution to Thrombin Generation in Philadelphia-Negative Myeloproliferative Neoplasms: The "Circulating Wound" Model.
2021
Current cytoreductive and antithrombotic strategies in MPNs are mostly based on cell counts and on patient’s demographic and clinical history. Despite the numerous studies conducted on platelet function and on the role of plasma factors, an accurate and reliable method to dynamically quantify the hypercoagulability states of these conditions is not yet part of clinical practice. Starting from our experience, and after having sifted through the literature, we propose an in-depth narrative report on the contribution of the clonal platelets of MPNs—rich in tissue factor (TF)—in promoting a perpetual procoagulant mechanism. The whole process results in an unbalanced generation of thrombin and i…
Clinical features of the impact of eating disorders on the results of 13C-methacetin breath test for assessment of liver function in girls with anore…
2019
Introduction: This study was designed to assess the influence of chosen aspects of anorexia nervosa eating disorders (AN ED) on 13C-methacetin breath test (MBT) results. Material and methods: We investigated a group of 81 girls, including 41 patients with confirmed diagnosis of AN ED. The study group was divided in two subgroups. According to the DSM-5 classification, 25 underweight patients met the criteria of anorexia nervosa (AN), and 16 girls with BMI value > 5th percentile for age and sex were diagnosed as atypical anorexia nervosa (AAN). Laboratory tests assessing the liver function and the MBT were performed in all the participants of the study. Results: In all healthy females the va…
Correction to: Atypical pathogens in hospitalized patients with community-acquired pneumonia: a worldwide perspective (BMC Infectious Diseases, (2018…
2020
Following publication of the original article [1], the authors identified that they have been incorrectly tagged under the name of their related consortium GLIMP Study Group.