Search results for "Azine"

Culture and Politics of Laziness. From Fairy Tales to Oblomov and Bartleby

2021

La these de cet article est que la paresse n’est pas une propriete psychologique d’un sujet individuel mais un sentiment collectif : c’est une reaction, voire une rebellion, contre ceux qui nous enferment dans une culture qui voit l’activite comme une valeur supreme, souvent comme une fin en soi. La paresse est la reponse a ceux qui nous forcent a faire et a exagerer, a nous donner a nos occupations avec zele et constance, devouement total et perseverance aveugle. Donc, il n’est pas vrai qu’une personne paresseuse ne fait rien, ou plutot qu’elle fait tout ce qu’elle peut pour ne rien faire. Le paresseux travaille frenetiquement afin de creer les conditions parfaites qui lui permettent d’act…

Influence of temperature on mass transfer in an incomplete trapping single hollow fibre supported liquid membrane extraction of triazole fungicides.

2008

The influence of temperature in a single hollow fibre supported liquid membrane extraction of triazole fungicides with a stagnant acceptor phase was investigated. The mass transfer parameters such as diffusion coefficient, flux and apparent viscosity were determined at temperature ranging from 278 K to 313 K. Increase in temperature led to an increase in diffusion coefficient and flux. The apparent viscosity also decreased with an increase in temperature. The degree of trapping in the acceptor phase influenced the mass transfer at higher temperature. At lower temperature, the transport of analytes from the donor solution through the donor-membrane interface and through the membrane mainly a…

The use of English in the construction of Christian youth identities in a Finnish youth magazine

2006

"Uteliaille toimittajille pettymystä ei näytetä". Kaunokirjallisen journalismin poetiikkaa aikakauslehtireportaasissa.

2008

Acetic Acid Mediated for One-Pot Synthesis of Novel Pyrazolyl s-Triazine Derivatives for the Targeted Therapy of Triple-Negative Breast Tumor Cells (…

2022

Here, we described the synthesis of novel pyrazole-s-triazine derivatives via an easy one-pot procedure for the reaction of β-dicarbonyl compounds (ethylacetoacetate, 5,5-dimethyl-1,3-cyclohexadione or 1,3-cyclohexadionone) with N,N-dimethylformamide dimethylacetal, followed by addition of 2-hydrazinyl-4,6-disubstituted-s-triazine either in ethanol-acetic acid or neat acetic acid to afford a novel pyrazole and pyrazole-fused cycloalkanone systems. The synthetic protocol proved to be efficient, with a shorter reaction time and high chemical yield with broad substrates. The new pyrazolyl-s-triazine derivatives were tested against the following cell lines: MCF-7 (breast cancer); MDA-MB-231 (tr…

One-Pot Synthesis, X-ray Single Crystal and Molecular Insight of Enaminone-Based β-Morpholino-/N-Methylpiperazinyl-/Pyrrolidinylpropiophenone

2020

One-pot synthesis of three enaminones, (E)-1-(4-chlorophenyl)-3-morpholinoprop-2-en-1-one 1, (E)-1-(4-chlorophenyl)-3-(4-methylpiperazin-1-yl)prop-2-en-1-one 2, and (E)-1-(4-chlorophenyl)-3-(pyrrolidin-1-yl)prop-2-en-1-one 3 were achieved. The synthetic protocol via three components reaction of p-chloroacetophenone with DMFDMA (N,N-dimethylformamid-dimethylacetal) and the corresponding secondary amines (morpholine/N-methylpiperazine/pyrrolidine) in dioxane under heating for 2.5–4 h at 102 °C yielded the requisite enaminones. This protocol has the advantage of no separation of intermediate, no need for column purification with quantitative yield for the target compounds. The chemical feature…

Framing sustainable lifestyles : organic consumption in a women's magazine

2017

Forms of sustainable lifestyles and more responsible ways to consume have become more popular in recent years. This is reflected also in that mainstream media discusses about sustainability. Similarly, there is a growing interest on organic produce, the organic market has grown steadily from the turn of the century. Due to the growing popularity of sustainability, the way media communicates about the issue, is of interest. This thesis studied how women’s magazines communicate about sustainable lifestyles, and sustainability in general. Especially, how the use of organic goods is reasoned and presented in a magazine is studied. The aim of the thesis was to uncover the frames, which the magaz…

Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging

2019

Background Pretargeted imaging allows the use of short-lived radionuclides when imaging the accumulation of slow clearing targeting agents such as antibodies. The biotin-(strept)avidin and the bispecific antibody-hapten interactions have been applied in clinical pretargeting studies; unfortunately, these systems led to immunogenic responses in patients. The inverse electron demand Diels-Alder (IEDDA) reaction between a radiolabelled tetrazine (Tz) and a trans-cyclooctene (TCO)-functionalized targeting vector is a promising alternative for clinical pretargeted imaging due to its fast reaction kinetics. This strategy was first applied in nuclear medicine using an 111In-labelled Tz to image TC…

Synthesis of pyrazole-4-carbohydrazide derivatives of pharmaceutical interest

2003

New 1-phenylor 1-methyl-5-benzamidopyrazole-4-carbohydrazide derivatives were prepared in 70–90% yields from 1-methylor 1-phenyl-6-phenylpyrazolo[3,4-d]1,3-oxazin-4(1H)-one derivatives and hydrazine hydrate. Small quantities of the isomeric 5-aminopyrazole-4-(Nbenzoyl)hydrazides were detected in some reaction mixtures, proving that intramolecular benzoyl migration can take place in the 5-benzamidopyrazole-4-carbohydrazide molecule. The direct formation of pyrazole-4-carbohydrazides from 5-benzamidopyrazole-4-carboxylic acid ethyl esters and hydrazine hydrate was unsuccessful.

Distribution and depletion of sulfadiazine after a multiple per os dosing in gilthead sea bream (Sparus aurata) fed two different diets

2013

The distribution and depletion profile of sulfadiazine (SDZ) were investigated in gilthead sea bream (Sparus aurata) fed on fish oil (FO) or plant oil-based (PO) diets. Fish averaging 230 g were given medicated feed containing 25 mg SDZ kg-1 fish for 5 days at 24-26°C. Blood and muscle plus skin were sampled on days 1, 3, 5, 6, 8 and 9. Differences in plasma and fillet SDZ levels between the two groups were statistically insignificant. The maximum drug concentrations in plasma were 3.2 ± 1.9 μg mL-1 and 2.9 ± 1.2 μg mL-1 in the PO and FO groups, respectively. In post-medicated samples depletion rapidly reached concentrations close to the level of quantification at 72 h post medication. With…