Search results for "B3"
showing 10 items of 193 documents
Host Cell Rab GTPases in Hepatitis B Virus Infection
2018
Hepatitis B virus (HBV) is a leading cause of liver disease and is presently estimated to infect more than 250 million humans. The extremely successful spread of this virus among the human population is explained by its effective transmission strategies and its manifold particle types, including virions, empty envelopes and naked capsids. Due to its tiny genome, HBV depends on cellular machineries to thrive in infected hepatocytes. To enter, traverse and exit the cell, HBV exploits host membrane trafficking pathways, including intracellular highways directed by Rab GTPases. Here, we review recent discoveries focused on how HBV co-opts and perturbs host Rab GTPase functions with an emphasis …
The integration of autophagy and cellular trafficking pathways via RAB GAPs.
2015
Macroautophagy is a conserved degradative pathway in which a double-membrane compartment sequesters cytoplasmic cargo and delivers the contents to lysosomes for degradation. Efficient formation and maturation of autophagic vesicles, so-called phagophores that are precursors to autophagosomes, and their subsequent trafficking to lysosomes relies on the activity of small RAB GTPases, which are essential factors of cellular vesicle transport systems. The activity of RAB GTPases is coordinated by upstream factors, which include guanine nucleotide exchange factors (RAB GEFs) and RAB GTPase activating proteins (RAB GAPs). A role in macroautophagy regulation for different TRE2-BUB2-CDC16 (TBC) dom…
Characterization of zolbetuximab in pancreatic cancer models
2018
ABSTRACT In healthy tissue, the tight junction protein Claudin 18.2 (CLDN18.2) is present only in the gastric mucosa. Upon malignant transformation of gastric epithelial tissue, perturbations in cell polarity lead to cell surface exposure of CLDN18.2 epitopes. Moreover, CLDN18.2 is aberrantly expressed in malignancies of several other organs, such as pancreatic cancer (PC). A monoclonal antibody, zolbetuximab (formerly known as IMAB362), has been generated against CLDN18.2. In a phase 2 clinical trial (FAST: NCT01630083), zolbetuximab in conjunction with chemotherapy prolonged overall and progression-free survival over chemotherapy alone and improved quality of life. In this study, the mech…
A novel GABRB3 variant in Dravet syndrome: Case report and literature review
2020
Abstract Background Mutations in GABRB3 have been identified in subjects with different types of epilepsy and epileptic syndromes, including West syndrome (WS), Dravet syndrome (DS), Lennox‐Gastaut syndrome (LGS), myoclonic‐atonic epilepsy (MAE), and others. Methods and results We herewith report on a girl affected by DS, who has been followed from infancy to the current age of 18 years. Next‐generation sequencing (NGS)‐based genetic testing for multigene analysis of neurodevelopmental disorders identified two likely de novo pathogenic mutations, a missense variant in GABRB3 gene (c.842 C>T; p.Thr281IIe) and a nonsense variant found in BBS4 gene (c.883 C>T; p.Arg295Ter). Conclusion A likely…
Oxidative stress biomarkers in Fabry disease: is there a room for them?
2020
Abstract Background Fabry disease (FD) is an X-linked lysosomal storage disorder, caused by deficient activity of the alpha-galactosidase A enzyme leading to progressive and multisystemic accumulation of globotriaosylceramide. Recent data point toward oxidative stress signalling which could play an important role in both pathophysiology and disease progression. Methods We have examined oxidative stress biomarkers [Advanced Oxidation Protein Products (AOPP), Ferric Reducing Antioxidant Power (FRAP), thiolic groups] in blood samples from 60 patients and 77 healthy controls. Results AOPP levels were higher in patients than in controls (p < 0.00001) and patients presented decreased levels of…
Machine $B_4$
2020
We construct map $\xi$. It exhibits dense orbits for all $x\in\overline{0,1}^\omega$. We give elementary proofs for all statements.
Space-filling vs. Luzin's condition (N)
2013
Let us assume that we are given two metric spaces, where the Hausdorff dimension of the first space is strictly smaller than the one of the second space. Suppose further that the first space has sigma-finite measure with respect to the Hausdorff measure of the corresponding dimension. We show for quite general metric spaces that for any measurable surjection from the first onto the second space, there is a set of measure zero that is mapped to a set of positive measure (both measures are the Hausdorff measures corresponding to the Hausdorff dimension of the first space). We also study more general situations where the measures on the two metric spaces are not necessarily the same and not ne…
Critical points in open sublevels and multiple solutions for parameter-depending quasilinear elliptic equations
2014
We investigate the existence of multiple nontrivial solutions of a quasilinear elliptic Dirichlet problem depending on a parameter $\lambda>0$ of the form $$ -\Delta_pu=\lambda f(u)\quad\mbox{in }\ \Omega,\quad u=0\quad\mbox{on }\ \partial\Omega, $$ where $\Omega\subset \mathbb{R}^N$ is a bounded domain, $\Delta_p$, $1 < p < +\infty$, is the $p$-Laplacian, and $f: \mathbb{R}\to \mathbb{R}$ is a continuous function satisfying a subcritical growth condition. More precisely, we establish a variational approach that when combined with differential inequality techniques, allows us to explicitly describe intervals for the parameter $\lambda$ for which the problem under consideration admits nontri…
Strong BV-extension and W1,1-extension domains
2021
We show that a bounded domain in a Euclidean space is a $W^{1,1}$-extension domain if and only if it is a strong $BV$-extension domain. In the planar case, bounded and strong $BV$-extension domains are shown to be exactly those $BV$-extension domains for which the set $\partial\Omega \setminus \bigcup_{i} \overline{\Omega}_i$ is purely $1$-unrectifiable, where $\Omega_i$ are the open connected components of $\mathbb{R}^2\setminus\overline{\Omega}$.
Quantization of Poisson Lie Groups and Applications
1996
LetG be a connected Poisson-Lie group. We discuss aspects of the question of Drinfel'd:can G be quantized? and give some answers. WhenG is semisimple (a case where the answer isyes), we introduce quantizable Poisson subalgebras ofC ∞(G), related to harmonic analysis onG; they are a generalization of F.R.T. models of quantum groups, and provide new examples of quantized Poisson algebras.