Search results for "BASAL"

A cardiovascular educational intervention for primary care professionals in Spain: positive impact in a quasi-experimental study

2015

Background Routine general practice data collection can help identify patients at risk of cardiovascular disease. Aim To determine whether a training programme for primary care professionals improves the recording of cardiovascular disease risk factors in electronic health records. Design and setting A quasi-experimental study without random assignment of professionals. This was an educational intervention study, consisting of an online-classroom 1-year training programme, and carried out in the Valencian community in Spain. Method The prevalence rates of recording of cardiovascular factors (recorded every 6 months over a 4-year period) were compared between intervention and control group. …

Contrasting neurochemical and behavioral profiles reflects stress coping styles but not stress responsiveness in farmed gilthead seabream (Sparus aur…

2020

In fish, as well as in other vertebrates, contrasting suites of physiological and behavioral traits, or coping styles, are often shown in response to stressors. However, the magnitude of the response (i.e. stress responsiveness) has been suggested to be independent of stress coping style. One central neurotransmitter that has been associated with both stress responsiveness and differences in stress coping styles is serotonin (5-hydroxytryptamine, 5-HT). In this study, we investigated to what extent stress responsiveness reflects differences in stress coping, and the potential involvement of the 5-HT system in mediating such differences in farmed Gilthead seabream. Initially, fish were class…

The mitotic spindle protein SPAG5/Astrin connects to the Usher protein network postmitotically

2011

Abstract Background Mutations in the gene for Usher syndrome 2A (USH2A) are causative for non-syndromic retinitis pigmentosa and Usher syndrome, a condition that is the most common cause of combined deaf-blindness. To gain insight into the molecular pathology underlying USH2A-associated retinal degeneration, we aimed to identify interacting proteins of USH2A isoform B (USH2AisoB) in the retina. Results We identified the centrosomal and microtubule-associated protein sperm-associated antigen (SPAG)5 in the retina. SPAG5 was also found to interact with another previously described USH2AisoB interaction partner: the centrosomal ninein-like protein NINLisoB. Using In situ hybridization, we foun…

TOPORS, implicated in retinal degeneration, is a cilia-centrosomal protein.

2011

et al.

Quantification of Radiation Biomarkers in Leukocytes of Breast Cancer Patients Treated with Different Modalities of 3D-CRT or IMRT

2016

The goal of this study was to determine whether the quantification of radiation biomarkers in peripheral leukocytes of 111 breast cancer patients after adjuvant treatment with different modalities of three-dimensional conformal radiation therapy (3D-CRT) or intensity-modulated radiation therapy (IMRT) revealed any difference in the patients' radiation burden by out-of-field doses and an associated risk of second malignancies. Whole-breast radiation therapy was performed by 3D-CRT using either a hard wedge (n = 32) or a virtual wedge (n = 49) at dose rates of 3 and 6 Gy per min each. Patients receiving additional radiotherapy to lymph nodes were treated by 3D-CRT (n = 21) or IMRT (n = 9). DN…

Eclogites and garnet pyroxenites: Similarities and differences

2010

Eclogites and garnet pyroxenites are genetically linked to basaltic precursors. Traditionally garnet pyroxenites are linked to fractionation of basaltic Magmas Over a range of mantle pressures and more recently they have been implicated in the genesis of ocean islands. in contrast eclogites are linked to the subduction of slab basalt and gabbro precursors which may be hydrothermally altered. Recently this subduction paradigm has been questioned. We present mineralogical, trace element and O isotopic data for eclogites and garnet pyroxenites that reveal some similarities but also important chemical and isotopic differences that support a distinct provenance (i.e., age and process). Continent…

PETROLOGICAL AND EXPERIMENTAL CONSTRAINTS OF THE PRE-ERUPTIVE CONDITIONS OF LA SOMMATA BASALT AND BROWN TUFFS TEPHRA (AEOLIAN ISLANDS)

2011

The principal focus of this thesis was the reconstruction of pre-eruptive conditions of two key eruptions at Vulcano island, the Brown Tuffs and the La Sommata, by combining the melt inclusion approach with phase equilibria derived by crystallization experiments. Brown Tuffs (the most energetic and widely distributed eruption of the Archipelago) were produced by several eruptions that occurred in a large age interval, 78-7.7 ka B.P. At Vulcano BT deposits crop out as proximal facies. La Sommata centre (age ca. 50 ka B.P.), is instead a basaltic scoria cone fed by one of the most primitive magmas of Aeolian Arc with ankaramitic affinity. Pyroxene-hosted melt inclusions on Lower and Intermedi…

P254 Survivin detection in saliva samples from patients with oral squamous cell carcinoma

2007

Potential Non-Invasive Biomarkers for Early Diagnosis of Oral Squamous Cell Carcinoma

2021

This study aimed to investigate the role of a panel of salivary cytokines as biomarkers for early detection oral squamous cell carcinoma (OSCC), comparing their levels among healthy individuals, patients with oral leukoplakia (OL), and malignant lesions. Cytokine profiling analysis performed in a minimally invasive sample was correlated with clinicopathological variables in our patient cohorts. Unstimulated saliva was obtained from subjects with OSCC at early (n = 33) and advanced (n = 33) disease, OL with homogeneous (n = 33) and proliferative verrucous (n = 33) clinical presentations, and healthy controls (n = 25). Salivary IL-1α, IL-6, IL-8, IP-10, MCP-1, TNF-α, HCC-1, and PF-4 levels we…

MPP1 links the Usher protein network and the Crumbs protein complex in the retina.

2007

Contains fulltext : 53571.pdf (Publisher’s version ) (Closed access) The highly ordered distribution of neurons is an essential feature of a functional mammalian retina. Disruptions in the apico-basal polarity complexes at the outer limiting membrane (OLM) of the retina are associated with retinal patterning defects in vertebrates. We have analyzed the binding repertoire of MPP5/Pals1, a key member of the apico-basal Crumbs polarity complex, that has functionally conserved counterparts in zebrafish (nagie oko) and Drosophila (Stardust). We show that MPP5 interacts with its MAGUK family member MPP1/p55 at the OLM. Mechanistically, this interaction involves heterodimerization of both MAGUK mo…