Search results for "BCS"

Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ribavirin

2015

Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release solid oral dosage forms containing ribavirin are reviewed. Ribavirin is highly soluble, but its permeability characteristics are not well defined. Therefore according to the Biopharmaceutical Classification System, and taking a “worst case” approach, ribavirin should be assigned to class III. As ribavirin is transported across the brush border membrane of the human jejunum by hCNT2, it shows saturable uptake in the intestine. However, no common excipients have been shown to compete for ribavirin absorption, nor have problems with BE of immediate release rib…

Justification of Biowaiver for Carbamazepine, a Low Soluble High Permeable Compound, in Solid Dosage Forms Based on IVIVC and Gastrointestinal Simula…

2009

The aim of the present study was to use gastrointestinal simulation technology and in vitro-in vivo correlation (IVIVC) as tools to investigate a possible extension of biowaiver criteria to BCS class II drugs using carbamazepine (CBZ) as a candidate compound. Gastrointestinal simulation based on the advanced compartmental absorption and transit model implemented in GastroPlus was used. Actual in vitro and in vivo data generated in CBZ bioequivalence studies were used for correlation purposes. The simulated plasma profile, based on the CBZ physicochemical and pharmacokinetic properties, was almost identical with that observed in vivo. Parameter sensitivity analysis (PSA) indicated that the p…

Fermionic superfluidity in optical lattices

2008

Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment

2014

A number of studies suggest that cancer stem cells are essential for tumour growth, and failure to target these cells can result in tumour relapse. As this population of cells has been shown to be resistant to radiation and chemotherapy, it is essential to understand their biology and identify new therapeutic approaches. Targeting cancer metabolism is a potential alternative strategy to counteract tumour growth and recurrence. Here we applied a proteomic and targeted metabolomic analysis in order to point out the main metabolic differences between breast cancer cells grown as spheres and thus enriched in cancer stem cells were compared with the same cells grown in adherent differentiating c…

Candesartan Cilexetil In Vitro-In Vivo Correlation: Predictive Dissolution as a Development Tool

2020

[EN] The main objective of this investigation was to develop an in vitro-in vivo correlation (IVIVC) for immediate release candesartan cilexetil formulations by designing an in vitro dissolution test to be used as development tool. The IVIVC could be used to reduce failures in future bioequivalence studies. Data from two bioequivalence studies were scaled and combined to obtain the dataset for the IVIVC. Two-step and one-step approaches were used to develop the IVIVC. Experimental solubility and permeability data confirmed candesartan cilexetil. Biopharmaceutic Classification System (BCS) class II candesartan average plasma profiles were deconvoluted by the Loo-Riegelman method to obtain th…

Noise correlations of the ultracold Fermi gas in an optical lattice

2008

In this paper we study the density noise correlations of the two component Fermi gas in optical lattices. Three different type of phases, the BCS-state (Bardeen, Cooper, and Schieffer), the FFLO-state (Fulde, Ferrel, Larkin, and Ovchinnikov), and BP (breach pair) state, are considered. We show how these states differ in their noise correlations. The noise correlations are calculated not only at zero temperature, but also at non-zero temperatures paying particular attention to how much the finite temperature effects might complicate the detection of different phases. Since one-dimensional systems have been shown to be very promising candidates to observe FFLO states, we apply our results als…

Many-body physics with ultracold gases

2007

This article reviews recent experimental and theoretical progress on many-body phenomena in dilute, ultracold gases. Its focus are effects beyond standard weak-coupling descriptions, like the Mott-Hubbard-transition in optical lattices, strongly interacting gases in one and two dimensions or lowest Landau level physics in quasi two-dimensional gases in fast rotation. Strong correlations in fermionic gases are discussed in optical lattices or near Feshbach resonances in the BCS-BEC crossover.

Quasiparticle Mean Field: BCS and Beyond

2007

In the previous two chapters we have laid the foundation for the BCS theory to describe open-shell nuclei. The properties of BCS solutions were compared with exact results from schematic solvable models. In this chapter we go into the details of numerical solution of the BCS equations. The implications of these solutions are discussed through applications to ds- and pf-shell nuclei.

Flat-band superconductivity in periodically strained graphene: mean-field and Berezinskii–Kosterlitz–Thouless transition

2019

In the search of high-temperature superconductivity one option is to focus on increasing the density of electronic states. Here we study both the normal and $s$-wave superconducting state properties of periodically strained graphene, which exhibits approximate flat bands with a high density of states, with the flatness tunable by the strain profile. We generalize earlier results regarding a one-dimensional harmonic strain to arbitrary periodic strain fields, and further extend the results by calculating the superfluid weight and the Berezinskii-Kosterlitz-Thouless (BKT) transition temperature $T_\text{BKT}$ to determine the true transition point. By numerically solving the self-consistency …

Flat-band superconductivity in periodically strained graphene : mean-field and Berezinskii–Kosterlitz–Thouless transition

2020

In the search of high-temperature superconductivity one option is to focus on increasing the density of electronic states. Here we study both the normal and s-wave superconducting state properties of periodically strained graphene, which exhibits approximate flat bands with a high density of states, with the flatness tunable by the strain profile. We generalize earlier results regarding a one-dimensional harmonic strain to arbitrary periodic strain fields, and further extend the results by calculating the superfluid weight and the Berezinskii–Kosterlitz–Thouless (BKT) transition temperature T BKT to determine the true transition point. By numerically solving the self-consistency equation, w…