Search results for "BES"

A synergic nanoantioxidant based on covalently modified halloysite–trolox nanotubes with intra-lumen loaded quercetin

2016

We describe the preparation and properties of the first example of a synergic nanoantioxidant, obtained by different functionalizations of the external surface and the inner lumen of halloysite nanotubes (HNTs). Trolox, a mimic of natural α-tocopherol, was selectively grafted on the HNT external surface; while quercetin, a natural polyphenolic antioxidant, was loaded into the inner lumen to afford a bi-functional nanoantioxidant, HNT–Trolox/Que, which was investigated for its reactivity with transient peroxyl radicals and a persistent 1,1-diphenyl-2-picrylhydrazyl (DPPH˙) radical in comparison with the corresponding mono-functional analogues HNT–Trolox and HNT/Que. Both HNT–Trolox and HNT/Q…

Clay nanotubes/ionic surfactant: Smart hybrid nanomaterials for the solubilization of hydrophobic compounds in aqueous media

2013

Influence of Geographical Area and Living Setting on Children's Weight Status, Motor Coordination, and Physical Activity

2022

This study was aimed (i) to examine the effect of living setting (rural vs. urban), geographical area (North vs. Center vs. South), and gender (boys vs. girls) on weight status, motor coordination, and physical activity (PA) level of Italian school-age children; (ii) to examine differences in the neighborhood walkability of different school areas from different geographical areas and living settings; and (iii) to examine whether motor coordination, PA level, geographical areas, living setting, neighborhood walkability, and gender could predict children's weight status. We assessed anthropometric parameters, gross motor coordination, and PA level in 1,549 children aged between 8 and 13 years…

Protective Effects of a Discontinuous Treatment with Alpha-Lipoic Acid in Obesity-Related Heart Failure with Preserved Ejection Fraction, in Rats

2020

Obesity induces hemodynamic and humoral changes that are associated with functional and structural cardiac remodeling, which ultimately result in the development of heart failure (HF) with preserved ejection fraction (HFpEF). In recent years, pharmacological studies in patients with HFpEF were mostly unsatisfactory. In these conditions, alternative new therapeutic approaches are necessary. The aim of our study was (1) to assess the effects of obesity on heart function in an experimental model and (2) to evaluate the efficacy of an alpha-lipoic acid (ALA) antioxidant treatment. Sprague-Dawley rats (7 weeks old) were either included in the control group (n = 6) or subjected to abdominal aorti…

Surface and interface effects on the current-voltage characteristic curves of multiwall carbon nanotube-Si hybrid junctions selectively probed throug…

2021

The possibility to increase the efficiency of photovoltaic (PV) cells based on hybrid carbon nanotube (CNT)–Si heterojunctions is related to the ability to control the chemical properties of the CNT–Si interface and of the CNT bundle layer. In spite of the encouraging performances of PV cells based on multiwall (MW) CNT, so far few efforts have been made in the study of this device compared to single wall (SW) CNT–Si interfaces. Here, surface and interface effects on the current–voltage characteristic curves of MW CNT–Si hybrid junctions are investigated through exposure to HF vapors and to 10 ppm-NO2 and compared to the effects detected in SW CNT–Si junctions. Quite similar results in term…

Short-term impact of biogas digestates on soils microbial communities

2022

International audience; Anaerobic digestion of organic waste is considered a key process to produce renewable energy to meet the growing sustainable energy demand. Digestates can be used in agriculture as soil amendments and improve crop yields. However, their use at large scale in agricultural fields still requires to prove their innocuity on soil biota, especially on microorganisms that play important roles in soil ecosystem. Here, we designed a microcosm experiment to compare the short-term (42-days) effects of four different digestates (derived from cattle manure, energy crop, food residues or slurry with bio-waste) on the soil microbial communities. Each digestate was applied on three …

Asociación de genes de la cadena mitocondrial respiratoria en el desarrollo de diabetes mellitus tipo 2 y parámetros relacionados

2017

Introducción: la diabetes mellitus tipo 2 (DMT2) es una enfermedad compleja, resultado de la combinación de factores ambientales, genéticos y adquiridos. Se ha convertido en una epidemia global que contribuye significativamente a la morbi-mortalidad prematura. Su heredabilidad es de un 70%; no obstante, los estudios realizados sólo han podido identificar una pequeña proporción de este componente genético. La cadena mitocondrial respiratoria (CMR) es esencial en el metabolismo energético y en la producción de especies reactivas del oxígeno (ROS). Un mal funcionamiento de este sistema biológico parece estar implicado en la DMT2 y otras alteraciones relacionadas (obesidad, hipertensión). Sin e…

Relación entre marcadores de riesgo cardiovascular y de estrés oxidativo con la presencia de hipertrofia ventricular izquierda y función diastólica e…

2015

La obesidad se caracteriza por un estado inflamatorio de bajo grado que produce alteraciones metabólicas y hemodinámicas a nivel sistémico. El conjunto de alteraciones cardiacas producidas por la obesidad, es lo que se conoce como “cardiomiopatía de la obesidad”. En adultos los mecanismos de la remodelación cardiaca en el contexto de la obesidad son complejos y dada la prevalencia de los trastornos comórbidos y las variables de confusión concomitantes con la obesidad es dificultoso caracterizar la cardiomiopatía propiamente debida a la obesidad. Existen cambios subclínicos tanto en la estructura como en la función (sistólica y diastólica) que se producen en el ventrículo izquierdo de los pa…

Ogļskābes anhidrāzes IX ietekme uz signālceļiem krūts vēža šūnu līnijās

2016

Ogļskābes anhidrāze IX (CAIX) ir hipoksijas inducēts enzīms, kas ir iesaistīts skābju-bāzu homeostāzes nodrošināšanā hipoksijas apstākļos. Pētījumi liecina, ka tā ir funkcionāli iesaistīta krūts vēža progresijā un nesen identificēta kā zāļu mērķis. Šajā darbā mēs centāmies noskaidrot, kā CAIX ietekmē dažādu signālceļu aktivitāti krūts vēža šūnās. Lai iegūtu ieskatu procesos, ko ietekmē ogļskābes anhidrāze IX (CAIX), darbā tika izmantotas trīs dažādu subtipu krūts vēža šūnu līnijas ar aktīvu vai nomāktu CAIX gēnu. Šīs šūnu līnijas tika kultivētas hipoksiskos un normokiskos apstākļos, kas tika pierādīti ar imunocitoķīmijas un Vesterna blota analīzēm. No šīm šūnām tika izdalīta augstas kvalitā…

Actualisation des références nutritionnelles françaises en vitamines et minéraux

2021

En 2016, l’Anses a proposé une mise à jour des références nutritionnelles pour la population adulte (femmes de 18 à 54 ans et hommes de 18 à 64 ans) dans le cadre de l’actualisation des repères de consommation alimentaire (saisine 2012-SA-0103). Par la suite, des rapports dédiés aux repères de consommation alimentaire pour les populations spécifiques (personnes âgées, enfants, femmes enceintes et allaitantes) ont été publiés en 2019, sans toutefois quede nouvelles références nutritionnelles ne soient définies par l’agence.Par ailleurs, la mise à jour de 2016 n’a concerné que les vitamines et minéraux indispensables pour lesquelles des données de consommation étaient disponibles. De ce fait,…