Search results for "BIOFILM"
showing 10 items of 394 documents
Synthesis and biological evaluation of new imidazo[2,1-b][1,3,4]thiadiazole derivatives: as anticancer and antibiofilm agents, and preclinical invest…
2020
Original data for manuscript: Quantity and Quality of Aquaculture Enrichments Influence Disease Epidemics and Provide Ecological Alternatives to Anti…
2021
The data processed and analyzed in this study are given in a single file: Karvonen et al. exposure data.xlsx. For detailed description of the material, methods and results of the study, see the article.
Attrezzi di legno per produzioni casearie tipiche siciliane
2018
La Sicilia è una regione influenzata da diverse culture. In seguito alla sua posizione centrale nel Mar Mediterraneo, essa ha subito la dominazione da parte dei Greci, dei Romani, dei Vandali, degli Arabi, dei Normanni e degli Spagnoli che si sono succeduti nelle conquiste dei territori regionali. Diverse sono le leggende legate ai cibi siciliani e ai loro processi produttivi; una leggenda attribuisce proprio alla regione Sicilia, precisamente alla zona di Pergusa nell’attuale provincia di Enna, la nascita del formaggio. Betta e Cantarelli (2000) raccontano che il pastore Aristeo, figlio del dio Apollo e della ninfa Cerere, abbia insegnato agli uomini l’arte della trasformazione del latte i…
Quantity and Quality of Aquaculture Enrichments Influence Disease Epidemics and Provide Ecological Alternatives to Antibiotics
2021
Environmental heterogeneity is a central component influencing the virulence and epidemiology of infectious diseases. The number and distribution of susceptible hosts determines disease transmission opportunities, shifting the epidemiological threshold between the spread and fadeout of a disease. Similarly, the presence and diversity of other hosts, pathogens and environmental microbes, may inhibit or accelerate an epidemic. This has important applied implications in farming environments, where high numbers of susceptible hosts are maintained in conditions of minimal environmental heterogeneity. We investigated how the quantity and quality of aquaculture enrichments (few vs. many stones
Novel Sortase A (SrtA) inhibitors interfere with the formation of staphylococcal biofilms
2013
Staphylococcus aureus, due to its wide arsenal of virulence factors, is a very versatile pathogen responsible for a wide variety of infectious diseases. The virulence factors include the cell-wall associated proteins that have a direct role in the first stage of pathogenesis. The Sortase A (SrtA) transpeptidase is responsible for covalent anchoring to the cell wall of various surface proteins and it is considered a good target to design new antivirulence agents. In this study, we report the identification of an inhibitor of SrtA afforded from the random screening of a small molecular library of around 150 synthetic compounds, through a high throughput assay by using the standard Dabcyl-QALP…
New Topsentin analogs as inhibitors of biofilm formation
Paracentrin 1, a synthetic antimicrobial peptide fragment of a beta-thymosin from the sea-urchin Paracentrotus lividus, interferes with staphylococca…
2014
UCT-MBR vs IFAS-UCT-MBR for Wastewater Treatment: A Comprehensive Comparison Including N2O Emission
2017
In this study the performance (in terms of carbon and nutrient removal) and N2O emission of two plant configurations adopting innovative technologies were investigated. With this regards, an University Cape Town (UCT) membrane bioreactor (MBR) plant and an Integrated Fixed Film Activated Sludge (IFAS) -UCT-MBR plant were monitored. Both plants treat real wastewater under two different values of the influent carbon nitrogen ratio (C/N = 5 mgCOD/mgN and C/N = 10 mgCOD/mgN). Results have shown the highest carbon and nutrients removal efficiencies for the IFAS-UCT-MBR configuration during both the two investigated C/N values. Furthermore, the lowest N2O emission occurred for the IFAS-UCT-MBR.
Staphylococcus epidermidis biofilmu veidošana un rezistences pret meticilīnu noteikšana, lietojot fenotipiskās un molekulāri bioloģiskās izmeklēšanas…
2018
Staphylococcus epidermidis ir veselas cilvēka ādas un gļotādas dabiskās mikrofloras sastāvdaļa, kas ir viens no visbiežāk sastopamajiem cilvēka mikrobioma pārstāvjiem. Epidermālais stafilokoks ir oportūnists, kas saimniekorganismam spēj kolonizēt gan ādu, gan gļotādu. Kaut arī S. epidermidis piemīt mazāk virulences faktoru, nekā radiniekam S. aureus, epidermālais stafilokoks ir kļuvis par vienu no visbiežāk izolētajiem koagulāzes negatīvajiem stafilokokiem intrahospitālajā vidē. Tomēr neskatoties uz to, ka epidermālajam stafilokokam ir mazāk virulences faktoru, tas ir kļuvis par nopietnu un komplicētu problēmjautājumu gan ārstniecības iestādēm, gan sabiedrības veselībai kopumā. Pētījuma mēr…
ANTI-STAPHYLOCOCCAL BIOFILM ACTIVITY OF NOVEL SORTASE A (SRTA) INHIBITORS
2013
Pathogenic staphylococci have an extraordinary ability to form biofilms. This characteristic is likely the most important virulence factor of staphylococci in the development of the chronic form of infectious diseases and in biomaterial associated infections (BAI). Staphylococcal biofilms are particularly dangerous because they are more resistant to host immune defence system and have a significantly increased tolerance to conventional antibiotics. There is undoubtedly an urgent need for novel treatments, strategies and anti-staphylococcal biofilm agents. The Sortase A (SrtA) transpeptidase is responsible for covalent anchoring to the cell wall of various surface proteins (FnbpA, FnbpB, Clf…