Search results for "BM"

Co-evolution between streaming and live music leads a way to the sustainable growth of music industry : Lessons from the US experiences

2017

While digitization of music, particularly streaming services, has gained increasing popularity, it has also led to a steady decline in the revenues of recorded music industry. This is causing strong concern regarding a potential collapse of the music industry comparable to other print media industries such as newspaper and book publishing. However, recent changes in the music industry initiated by a resurgence of the live music industry are giving rise to some expectations for the survival and growth of the music industry. The parallel paths of increasing popularity of streaming services and a resurgence of live music suggest that these two dynamics are working together in a co-evolutionary…

Apoptotic-like Leishmania exploit the host´s autophagy machinery to reduce T-cell-mediated parasite elimination

2015

Apoptosis is a well-defined cellular process in which a cell dies, characterized by cell shrinkage and DNA fragmentation. In parasites like Leishmania, the process of apoptosis-like cell death has been described. Moreover upon infection, the apoptotic-like population is essential for disease development, in part by silencing host phagocytes. Nevertheless, the exact mechanism of how apoptosis in unicellular organisms may support infectivity remains unclear. Therefore we investigated the fate of apoptotic-like Leishmania parasites in human host macrophages. Our data showed--in contrast to viable parasites--that apoptotic-like parasites enter an LC3(+), autophagy-like compartment. The compartm…

Pyöräilyyn suunnitellun epäsuoran VO2max -testin validointi

2016

Aerobisen suorituskyvyn määrittäjänä käytetään usein maksimaalista hapenottokykyä (VO2max). VO2max -arvojen avulla voidaan muun muassa monitoroida yksilön harjoittelustatusta tai terveydentilaa. Tämän tutkimuksen tarkoituksena oli selvittää kuinka tarkasti Firstbeat Technologies Oy:n kehittämä kuntotesti arvioi maksimaalista hapenkulutusta (VO2max), kun testi toteutetaan pyöräillen. Menetelmä laskee arvion VO2max -arvosta neuroverkkomallinnukseen perustuvalla menetelmällä, jossa käytetään määrittäjinä sykettä, kuormitusintensiteetin muutoksia (on/off -vaste) sekä sykevälivaihtelun avulla määritettyä hengitysfrekvenssiä. Tutkimukseen osallistui yhteensä 29 koehenkilöä, 15 naista (ikä 28,1 ± …

Dynaamisen jakeluketjun ja komponenttipohjaisen liiketoimintamallinnuksen soveltuvuuden vertailu verkostossa toimivan yrityksen organisaation kehittä…

2008

Non-melancholic depressive symptoms are associated with above average fat mass index in the Helsinki birth cohort study

2022

AbstractThere is an existing link between two of the most common diseases, obesity and depression. These are both of great public health concern, but little is known about the relationships between the subtypes of these conditions. We hypothesized that non-melancholic depressive symptoms have a stronger relationship with both body composition (lean mass and fat mass) and dysfunctional glucose metabolism than melancholic depression. For this cross-sectional study 1510 participants from the Helsinki Birth Cohort Study had their body composition evaluated as lean mass and fat mass (Lean Mass Index [LMI, kg/m2] + Fat Mass Index [FMI kg/m2] = Body Mass Index). Participants were evaluated for dep…

Obmowa, osądzanie, narzekanie czy milczenie? Rozważania Ojców Pustyni

2021

Pod koniec III wieku rozpoczyna się ruch monastyczny zainicjowany przez św. Antoniego, Powstała w ten sposób nowa forma ascezy charakteryzująca się zerwaniem ze światem, społeczeństwem: anachoreza, czyli pustelnictwo. Odtąd życie pustelników ma być pełne wyrzeczeń, na które składają się post, wstrzemięźliwość seksualna, modlitwa i praca, ale też milczenie. Wierzono bowiem, że tylko w ciszy brat otrzyma szansę na spotkanie Boga, usłyszenia Jego Słowa i tym samym wkroczy w Jego tajemnicę, a potem będzie mógł innych do tej tajemnicy doprowadzić, dzięki potędze swej miłości i pokory. Milczenie, zachowanie ciszy, powstrzymywanie się przed uwolnieniem słów były niezwykle ważnymi i częstymi temata…

Cinnamaldehyde Induces Expression of Efflux Pumps and Multidrug Resistance in Pseudomonas aeruginosa

2019

Essential oils or their components are increasingly used to fight bacterial infections. Cinnamaldehyde (CNA), the main constituent of cinnamon bark oil, has demonstrated interesting properties in vitro against various pathogens, including Pseudomonas aeruginosa. In the present study, we investigated the mechanisms and possible therapeutic consequences of P. aeruginosa adaptation to CNA. Exposure of P. aeruginosa PA14 to subinhibitory concentrations of CNA caused a strong albeit transient increase in the expression of operons that encode the efflux systems MexAB-OprM, MexCD-OprJ, MexEF-OprN, and MexXY/OprM. This multipump activation enhanced from 2- to 8-fold the resistance (MIC) of PA14 to …

Physiological and Nutritional Roles of PPAR across Species.

2013

There has been a tremendous amount of information produced on peroxisome proliferator-activated receptors (PPARs). The interest in PPARs was originally driven largely by their role in hypolipidemia and hepatocarcinogenesis, but it soon became evident that they played important roles in the metabolic syndrome and overall health of organisms including regeneration of tissues, differentiation, insulin signaling, overall lipid metabolism, and immune response (reviewed in [1–7]). From a nutritional standpoint, the PPARs are of extreme importance because of their ability to bind and be activated by long-chain fatty acids and their metabolites. Therefore, the PPARs are recognized as ideal candidat…

Signal transduction in isolated fat body from the cockroach Blaptica dubia exposed to hypertrehalosaemic neuropeptide

1998

Hypertrehalosaemic hormones stimulate trehalogenesis while inhibiting glycolysis in cockroach fat body. Signal transduction of the hypertrehalosaemic peptide Bld HrTH was examined in isolated fat body of the Argentine cockroach Blaptica dubia with respect to its effects on the increase in trehalose production and decrease in the content of the glycolytic activator fructose 2,6-bisphosphate in the tissue. Cyclic AMP does not seem to be involved in these processes as the cAMP analogue cpt-cAMP and the phosphodiesterase inhibitor IBMX, which both permeate cell membranes, had no effect on either parameter. Octopamine at physiological concentrations (10−7 mol · l−1) was also ineffective, but at …

Bone mineral density, osteoporosis, and fractures among people with eating disorders: a systematic review and meta-analysis

2016

Objective: To provide meta-analytical evidence of bone mineral density (BMD), fractures, and osteoporosis rates in eating disorders (ED) vs. healthy controls (HCs). Method: Three independent authors searched major electronic databases from inception till August 2015 for cross-sectional studies reporting BMD in people with ED (anorexia nervosa, (AN); bulimia nervosa, (BN); eating disorders not otherwise specified, (EDNOS)) vs. HCs. Standardized mean differences (SMDs) ±95% and confidence intervals (CIs) were calculated for BMD, and odds ratios (ORs) for osteopenia, osteoporosis, and fractures. Results: Overall, 57 studies were eligible, including 21 607 participants (ED = 6485, HCs = 15 122)…