Search results for "BNCT"

Gamma component dosimetry in the thermal column of the TRIGA reactor in Pavia

2015

This presentation describes the assessment of the gamma rays spectrum and dose. Yhe result have been used to perform dosimetry in cell cultures for in-vitro BNCT studies.

Caratterizzazione dosimetrica della facility a neutroni termici del reattore TRIGA di Pavia: studio della dose da fotoni mediante rivelatori ESR di a…

2014

The optimization of the procedures of Neutron Capture Therapy (NCT) for cancer treatments involves research for beam characterization. One major issue for this therapy is the reliable dosimetric determination of the various (neutronic and photonic) components of the employed beam. In particular, the precise and accurate measurements of the gamma photon component is fundamental for evaluating the risks to healthy tissues hit by the mixed field. Among solid state dosimeters the alanine detectors read by Electron Paramagnetic Resonance (EPR) technique present several advantages such as: tissue equivalence for photon and electron beams, linearity of its dose-response over a wide range, high sta…

Aza-BODIPY: A New Vector for Enhanced Theranostic Boron Neutron Capture Therapy Applications

2020

Boron neutron capture therapy (BNCT) is a radiotherapeutic modality based on the nuclear capture of slow neutrons by stable 10B atoms followed by charged particle emission that inducing extensive damage on a very localized level (&lt

The FiR 1 photon beam model adjustment according to in-air spectrum measurements with the Mg(Ar) ionization chamber.

2014

Abstract The mixed neutron–photon beam of FiR 1 reactor is used for boron–neutron capture therapy (BNCT) in Finland. A beam model has been defined for patient treatment planning and dosimetric calculations. The neutron beam model has been validated with an activation foil measurements. The photon beam model has not been thoroughly validated against measurements, due to the fact that the beam photon dose rate is low, at most only 2% of the total weighted patient dose at FiR 1. However, improvement of the photon dose detection accuracy is worthwhile, since the beam photon dose is of concern in the beam dosimetry. In this study, we have performed ionization chamber measurements with multiple b…

Potentialities of High-Resolution 3-D CZT Drift Strip Detectors for Prompt Gamma-Ray Measurements in BNCT

2022

Recently, new high-resolution cadmium–zinc–telluride (CZT) drift strip detectors for room temperature gamma-ray spectroscopic imaging were developed by our group. The CZT detectors equipped with orthogonal anode/cathode collecting strips, drift strips and dedicated pulse processing allow a detection area of 6 × 20 mm2 and excellent room temperature spectroscopic performance (0.82% FWHM at 661.7 keV). In this work, we investigated the potentialities of these detectors for prompt gamma-ray spectroscopy (PGS) in boron neutron capture therapy (BNCT). The detectors, exploiting the measurement of the 478 keV prompt gamma rays emitted by 94% 7Li nuclides from the 10B(n, α)7…

Genetics and genomics of BNCT among basics and perspectives

2017

The Boron neutron capture therapy (BNCT) bases its therapeutic action on the selective ability to induce DNA damage of tumor cells with the aim to cause their death by apoptosis or necrosis, preserving as much as possible the normal cells. The genetic variability is an evolutionary mechanism of species survival and improvement according to which diversity in genetic configurations exists among individuals of a population, revealed also in different tolerance to insults and reparative ability of DNA damage induced by physical and chemical agents. A tumor, due to its intrinsic genomic instability, acquires the mutator phenotype and may, during the cell duplications, generate in the same indiv…

Caratterizzazione del campo misto neutroni-gamma nella colonna termica del reattore TRIGA di Pavia tramite attivazione neutronica e rivelatori ad ala…

2014

Phenol compounds for Electron Spin Resonance dosimetry of gamma and neutron beams

2014

Determination of gamma component in thermal column of Pavia Triga reactor by using alanine ESR detectors

2014

Synthesis and Characterisation of Functionalized borosilicate nanoparticles for boron neutron capture therapy applications

2012

Boron Neutron Capture Therapy (BNCT) is a promising therapy for the cure of diffuse tumors. The successful clinical application of BNCT requires finding new boron-based compounds suitable for an efficient 10B delivery to the cancerous tissues. The purpose of this work is to synthesize borosilicate nanoparticles by a sol–gel recipe, and to functionalize them with folic acid in order to promote their capture by the tumor cells. Whereas sol–gel is a promising technique for the synthesis of nanoparticles, in case of borosilicate systems this approach is affected by significant boron loss during preparation. Here we show that functionalization of borosilicate nanoparticles with folic acid can re…