Search results for "BNP"
showing 10 items of 23 documents
Long-term cardiac pro-B-type natriuretic peptide gene delivery prevents the development of hypertensive heart disease in spontaneously hypertensive r…
2011
Background— Diastolic dysfunction associated with high blood pressure (BP) leads to cardiac remodeling and fibrosis and progression to congestive heart failure. B-type natriuretic peptide (BNP) has BP-lowering, antifibrotic, and antihypertrophic properties, which makes BNP an attractive agent for attenuating the adverse cardiac remodeling associated with hypertension. In the current study, we tested the effects of sustained cardiac proBNP gene delivery on BP, cardiac function, and remodeling in spontaneously hypertensive rats (SHR). Methods and Results— We used the myocardium-tropic adeno-associated virus serotype 9 (AAV9) vector to achieve continuously enhanced cardiac rat proBNP expressi…
NT-pro-BNP nozīme agrīnā HSM diagnostikā 2. tipa cukura diabēta pacientiem
2020
Ievads. Pacientiem ar otrā tipa cukura diabētu ir ievērojami lielāks risks attīstīties kardiovaskulārai slimībai. Lielai daļai pacientu ar otrā tipa diabētu var attīstīties kardiovaksulāra saslimšana bez tipiskas klīniskās ainas, kā rezultātā kardiovaskulāru slimību diagnosticē novēloti, kad tā jau ir progresējusi. Līdz ar to būtu svarīgi šiem pacientiem veikt skrīningu, lai priekšlaicīgi diagnosticētu vai novērstu kardiovaskulāru slimību attīstību – noteikt NT-pro-BNP. Pētījuma mērķis. Pētīt NT-pro-BNP izmaiņas otrā tipa cukura diabēta pacientiem, kuriem slimības vēsturē nav kardiovaskulāru saslimšanu, un vai NT-pro-BNP līmenim asinīs ir saistība pacienta dzimumu, vecumu un slimošanas ar o…
Influencia de la diabetes experimental sobre los mecanismos implicados en la respuesta de las arterias carótida y renal de conejo al péptido natriuré…
2016
La diabetes constituye un importante factor de riesgo de la enfermedad cardiovascular, con una mayor prevalencia de ictus y nefropatía. El péptido natriurético tipo B (BNP) juega un papel importante en la fisiopatología cardiovascular y podría tener acciones protectoras cardiovasculares y nefrovasculares en pacientes diabéticos. En este trabajo hemos estudiado las modificaciones producidas por la diabetes en los mecanismos que regulan la respuesta de las arterias carótida y renal de conejo al BNP. La concentración plasmática de NT-proBNP en conejos diabéticos fue mayor que en conejos control. ARTERIA CARÓTIDA. El BNP indujo una relajación de la arteria carótida, que fue menor en conejo diab…
Diagnostic and prognostic values of B-type natriuretic peptides (BNP) and N-terminal fragment brain natriuretic peptides (NT-pro-BNP).
2012
Abstract B-type natriuretic peptide (BNP) is a member of a four-natriuretic peptide family that shares a common 17-peptide ring structure. The N-terminal fragment (NT-pro-BNP) is biologically inert, but both are secreted in the plasma in equimolar quantities and both have been evaluated for use in the management of congestive heart failure. BNP and NT-pro-BNP are frequently used in the diagnosis of congestive heart failure and distinguishing between patients with dyspnoea of cardiac or pulmonary origin. Values of NT-pro-BNP are affected by age or the presence of one or several co-morbidities such as chronic renal failure, type 2 diabetes, and acute coronary syndrome. ‘Normal’ values of thes…
Are BNP plasma levels useful in heart failure diagnosis each time? A dyspneic patient with anasarca.
2011
Immune-inflammatory and metabolic effects of high dose furosemide plus hypertonic saline solution (HSS) treatment in cirrhotic subjects with refracto…
2016
Introduction Patients with chronic liver diseases are usually thin as a result of hypermetabolism and malnutrition expressed by reduced levels of leptin and impairment of other adyponectins such as visfatin. Aims We evaluated the metabolic and inflammatory effects of intravenous high-dose furosemide plus hypertonic saline solutions (HSS) compared with repeated paracentesis and a standard oral diuretic schedule, in patients with cirrhosis and refractory ascites. Methods 59 consecutive cirrhotic patients with refractory ascites unresponsive to outpatient treatment. Enrolled subjects were randomized to treatment with intravenous infusion of furosemide (125-250mg⁄bid) plus small volumes of HSS …
Cardiac risk stratification in elective non-cardiac surgery: Role of NT-proBNP
2011
AIM: The aim of the study was to investigate the utility of NT-proBNP measurement for the stratification of presurgical cardiac risk. METHODS: Cardiac risk before elective non-cardiac surgery was evaluated in 82 consecutive patients. From each patient a venous blood sample was drawn to determinate NT-proBNP levels. Patients were followed up over three months in order to detect the occurrence of cardiac adverse events. RESULTS: NT-proBNP was positively correlated (P<0.0001) with age, days of hospitalization (P=0.001) and ASA class (P=0.001). High surgical risk (P<0.0001), diabetes (P=0.004), dyslipidemia (P=0.006) and elevated levels of NT-proBNP (P<0.0001) were significantly correlated with…
Natriuretic peptide system expression in murine and human submandibular salivary glands: a study of the spatial localisation of ANB, BNP, CNP and the…
2019
AbstractThe natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy murine and human submandibular salivary glands (SMGs). We show CNP is the dominant NP in mouse and human SMG and is expressed together with NP receptors in ducts, autonomic nerves and the microvasculature of the gland, suggesting CNP autocrine signalling may take place in some of these glandular structures. These data suggest the NP system may control salivary gland funct…
Short term prognostic role of NT-proBNP in patients after myocardial infarction
2009
Aim. The clinical and prognostic role of cardiac natriuretic peptides (CNP) in patients with heart failure is well known; recently, several studies have evaluated the possibility of using CNP to evaluate their potential prognostic role in patients with acute coronary syndromes (ACS). The aim of this study was to evaluate the short term prognostic value of NT-proBNP in 70 patients admitted for ACS. Methods. The authors studied 70 patients with ACS, evaluating, at admission, clinical-anamnestic, instrumental and laboratory characteristics including NT-proBNP plasma levels. Patients were monitored in a 6-month-follow-up to record adverse fatal events and their possible correlation with baselin…
Human Hypertension Is Characterized by a Lack of Activation of the Antihypertensive Cardiac Hormones ANP and BNP
2012
ObjectivesThis study sought to investigate plasma levels of circulating cardiac natriuretic peptides, atrial natriuretic peptide (ANP) and B-type or brain natriuretic peptide (BNP), in the general community, focusing on their relative differences in worsening human hypertension.BackgroundAlthough ANP and BNP are well-characterized regulators of blood pressure in humans, little is known at the population level about their relationship with hypertension. The authors hypothesized that hypertension is associated with a lack of activation of these hormones or their molecular precursors.MethodsThe study cohort (N = 2,082, age >45 years) was derived from a random sample from Rochester, Minnesota, …