Search results for "BOC"
showing 10 items of 477 documents
La fortuna della «Cronica» di Salimbene de Adam fra Trecento e Quattrocento
2018
Studio della fortuna della «Cronica» di Salimbene de Adam fra Tre e Quattrocento, in particolare in Dante, Boccaccio e Poggio Bracciolini.
Oligodendrocytes in mouse corpus callosum are coupled via gap junction channels formed by connexin47 and connexin32.
2010
According to previously published ultrastructural studies, oligodendrocytes in white matter exhibit gap junctions with astrocytes, but not among each other, while in vitro oligodendrocytes form functional gap junctions. We have studied functional coupling among oligodendrocytes in acute slices of postnatal mouse corpus callosum. By whole-cell patch clamp we dialyzed oligodendrocytes with biocytin, a gap junction-permeable tracer. On average 61 cells were positive for biocytin detected by labeling with streptavidin-Cy3. About 77% of the coupled cells stained positively for the oligodendrocyte marker protein CNPase, 9% for the astrocyte marker GFAP and 14% were negative for both CNPase and GF…
The diagnostic possibilities of Positron Emission Tomography (PET)
2014
Se describen los principios de la tomografía por emisión de positrones (PET) como procedimiento diagnóstico de reciente introducción en el campo de las Ciencias de la Salud. Las aplicaciones clínicas principales se dan en un grupo concreto de especialidades: la cardiología, neurología, psiquiatría y sobre todo la oncología. La tomografía por emisión de positrones es una técnica de diagnóstico por la imagen no invasiva de uso clínico. Se trata de una excelente herramienta para el estudio de la estadificación y la posible malignización de los tumores de cabeza y cuello, la detección de metástasis y linfoadenopatías no valorables clínicamente, así como para el diagnóstico de recidivas tumorale…
Characterization of cells with different mitochondrial membrane potential during apoptosis.
2005
Background Until now, the simultaneous analysis of several parameters during apoptosis, including DNA content and mitochondrial membrane potential (ΔΨ), has not been possible because of the spectral characteristics of the commonly used dyes. Using polychromatic flow cytometry based upon multiple laser and UV lamp excitation, we have characterized cells with different ΔΨ during apoptosis. Methods U937 cells were treated with the flavonoid quercetin (Qu) and stained with JC-1 to detect ΔΨ, propidium iodide (PI) for cell viability, Hoechst 33342 for DNA content, Annexin V conjugated with Alexa Fluor-647 for detection of phosphatidilserine (PS) exposure, marker of early apoptosis, or Mitotracke…
Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia
2021
Abstract SARS-CoV-2 vaccine ChAdOx1 nCoV-19 (AstraZeneca) causes a thromboembolic complication termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Using biophysical techniques, mouse models, and analysis of VITT patient samples, we identified determinants of this vaccine-induced adverse reaction. Super-resolution microscopy visualized vaccine components forming antigenic complexes with platelet factor 4 (PF4) on platelet surfaces to which anti-PF4 antibodies obtained from VITT patients bound. PF4/vaccine complex formation was charge-driven and increased by addition of DNA. Proteomics identified substantial amounts of virus production-derived T-REx HEK293 proteins in the ethyle…
Influence of Thrombotic Thrombocytopenic Purpura on Depressivity, Cognitive Conduction, Quality of Life, and Resilience of Patients
2020
Effect of customer heterogeneity on the relationship satisfaction–loyalty
2014
Abstract The need to study the differences among consumers due to their behavioural heterogeneity and the highly competitive consumer markets is recognized. In this paper, we analyse the potential heterogeneous shopping assessment in retail and how that experience may influence on consequent customer loyalty in a different way. The effects of satisfaction on attitudinal and behavioural loyalty and positive word of mouth are estimated by a finite-mixture structural equation model, and unobserved heterogeneity is analysed simultaneously. The results show that there are three latent segments where the strength of causal relationships differs which mean that there is an overestimation of the im…
The economic metaphor of Italian politics for dynamic coalition regeneration in the robocup competition of Aibo robots
2005
The variation version of the economic metaphor of Italian politics, an architecture that loosely takes inspiration from the political organizations of democratic governments, following the example of Italian government, and which provides a solution for the coordination of a spare colony of robots, is competent to allow the coordination of the behaviors of a team of four robots in order to play soccer in the Robocup competition. The development of an evolution of economic metaphor of Italian politics is now outlined. This new approach proposes a mechanism to make a new coalition caused by the failure of the government strategy and by a general inefficiency of the whole colony during the rea…
La ruse érotique et la ruse d'amour dans quelques contes et nouvelles de Sade
2000
Il contributo esamina il ruolo dell'astuzia nei racconti e nelle novelle di Sade. Se ne evidenzia il legame con la tradizione letteraria e, in particolare, con il Decameron di Boccaccio. L'astuzia caratterizza inoltre la peculiare ideologia dell'autore, che ne ritualizza le forme e ne codifica i mezzi.
Influence of Riboflavin Targeting on Tumor Accumulation and Internalization of Peptostar Based Drug Delivery Systems.
2020
Riboflavin carrier protein (RCP) and riboflavin transporters (RFVTs) have been reported to be highly overexpressed in various cancer cells. Hence, targeting RCP and RFVTs using riboflavin may enhance tumor accumulation and internalization of drug delivery systems. To test this hypothesis, butyl-based 3-arm peptostar polymers were synthesized consisting of a lysine core (10 units per arm) and a sarcosine shell (100 units per arm). The end groups of the arms and the core were successfully modified with riboflavin and the Cy-5.5 fluorescent dye, respectively. While in phosphate buffered saline the functionalized peptostars showed a bimodal behavior and formed supramolecular structures over tim…