Search results for "BODY"
showing 10 items of 6956 documents
Rac1-Regulated Endothelial Radiation Response Stimulates Extravasation and Metastasis That Can Be Blocked by HMG-CoA Reductase Inhibitors
2011
Radiotherapy (RT) plays a key role in cancer treatment. Although the benefit of ionizing radiation (IR) is well established, some findings raise the possibility that irradiation of the primary tumor not only triggers a killing response but also increases the metastatic potential of surviving tumor cells. Here we addressed the question of whether irradiation of normal cells outside of the primary tumor augments metastasis by stimulating the extravasation of circulating tumor cells. We show that IR exposure of human endothelial cells (EC), tumor cells (TC) or both increases TC-EC adhesion in vitro. IR-stimulated TC-EC adhesion was blocked by the HMG-CoA reductase inhibitor lovastatin. Glycyrr…
Enterobacter cloacae administration induces hepatic damage and subcutaneous fat accumulation in high-fat diet fed mice.
2018
Accumulating evidence indicates that gut microbiota plays a significant role in obesity, insulin resistance and associated liver disorders. Family Enterobacteriaceae and especially Enterobacter cloacae strain B29 have been previously linked to obesity and hepatic damage. The underlying mechanisms, however, remain unclear. Therefore, we comprehensively examined the effects of E. cloacae subsp. cloacae (ATCC® 13047™) administration on host metabolism of mice fed with high-fat diet (HFD). C57BL/6N mice were randomly divided into HFD control, chow control, and E. cloacae treatment groups. The E. cloacae treatment group received live bacterial cells in PBS intragastrically twice a week, every ot…
Trait-specific tracking and determinants of body composition: a 7-year follow-up study of pubertal growth in girls
2009
BACKGROUND: Understanding how bone (BM), lean (LM) and fat mass (FM) develop through childhood, puberty and adolescence is vital since it holds key information regarding current and future health. Our study aimed to determine how BM, LM and FM track from prepuberty to early adulthood in girls and what factors are associated with intra- and inter-individual variation in these three tissues. METHODS: The study was a 7-year longitudinal cohort study. BM, LM and FM measured using dual-energy X-ray absorptiometry, self-reported dietary information, leisure time physical activity (LTPA) and other factors were assessed one to eight times in 396 girls aged 10 to 13 years (baseline), and in 255 moth…
Il problema degli n-corpi in relatività generale
2019
Questa riproposizione in italiano dell’ultimo lavoro di Tullio Levi-Civita (1873- 1941) nasce da una esigenza culturale forte. Nel 2018 Padova e la sua Università hanno celebrato il loro grande scienziato con un importante convegno, accompagnato dalla ristampa di una selezione di suoi lavori, comprendente la sua tesi di laurea autografa. L’ultimo suo lavoro scientifico, “Le problème des n corps en relativité générale”, fu redatto in francese, e per le note vicende risalenti all’abominia fascista delle leggi razziali, fu stampato solo postumo, nel 1950, a cura dell’Accademia delle Scienze di Parigi.
Between looking back and moving ahead : an exploration of the role of the body and its movement in a music therapy case study
2017
We exist in this world through our bodies. Every single experience is stored in it, it helps us to communicate with others, relate and build meaningful relationships. However, when the connection to our experiences or the control over our body is disrupted by a traumatic experience or disease, we become disconnected from our genuine self and the world around us. Music therapy provides us with a space for integration – of painful or joyful memories, emotions, and our bodies. Especially in Western cultures this physical relationship to music is often neglected, even though music and dance probably developed simultaneously and are still very much the same in some African cultures. When we are …
Embodied Responsive Ethical Practice The Contribution of Merleau-Ponty for a Corporeal Ethics in Organizations
2015
Following a phenomenological understanding of the body and embodiment, this paper explores corporeal ethics as a practice in organisations. With the phenomenology of Merleau-Ponty, bodily dimensions and enfleshed intercorporeality are seen as media for ethically enacted and morally responsive, thus responsible forms of practicing and relationships. Then the article discusses specific forms of responsive and caring practices as well as the ethical relevance of bodies at work in organisations. Finally, practical, political, and theoretical implications are offered and perspectives for further investigating and incorporating practicing of ethics in organisations are outlined. peerReviewed
Acclimation capacity and rate change through life in the zooplankton Daphnia
2020
When a change in the environment occurs, organisms can maintain an optimal phenotypic state via plastic, reversible changes to their phenotypes. These adjustments, when occurring within a generation, are described as the process of acclimation. While acclimation has been studied for more than half a century, global environmental change has stimulated renewed interest in quantifying variation in the rate and capacity with which this process occurs, particularly among ectothermic organisms. Yet, despite the likely ecological importance of acclimation capacity and rate, how these traits change throughout life among members of the same species is largely unstudied. Here we investigate these rel…
The Clinical Value of Autoantibodies in Rheumatoid Arthritis
2018
Rheumatoid arthritis (RA) is a highly heterogeneous syndrome in terms of clinical presentation, progression, and response to therapy. In such a complicated context, the identification of disease-related biomarkers would be undoubtedly helpful in assisting tailored approaches for every patient. Despite remarkable efforts, however, progress in new biomarker development and validation is dramatically slow. At present, none of the candidate genetic, cellular, or molecular biomarker has yet surpassed the clinical value of RA-specific autoantibodies, including rheumatoid factor (RF) and anti-citrullinated protein autoantibodies (ACPA). Rather, recent years have witnessed significant advancements …
FRI0030 Anti-TNF-α Antibody Targeted To Inflamed Synovial Tissue for The Treatment of Rheumatoid Arthritis
2016
Background TNF-α neutralizing molecules represent one of the most efficient therapeutic approaches to control inflammation in rheumatoid arthritis (RA). The widespread distribution in the body induces the inhibition of TNF-α in all the tissues, requesting the use of high dose of this expensive drug. Another problem that has not yet been solved in the management of RA patients is how to reduce and possibly avoid the side effects, particularly the increased risk of common and opportunistic infections, which may be associated with long-term administration of these therapeutic drugs. Objectives The aim of the present investigation was to show that a recombinant protein obtained by fusing a syno…
Photoluminescent Detection of Human T-Lymphoblastic Cells by ZnO Nanorods.
2020
The precise detection of cancer cells currently remains a global challenge. One-dimensional (1D) semiconductor nanostructures (e.g., ZnO nanorods) have attracted attention due to their potential use in cancer biosensors. In the current study, it was demonstrated that the possibility of a photoluminescent detection of human leukemic T-cells by using a zinc oxide nanorods (ZnO NRs) platform. Monoclonal antibodies (MABs) anti-CD5 against a cluster of differentiation (CD) proteins on the pathologic cell surface have been used as a bioselective layer on the ZnO surface. The optimal concentration of the protein anti-CD5 to form an effective bioselective layer on the ZnO NRs surface was selected. …