Search results for "BREAST"

Shift Work and Prostate Cancer Incidence in Industrial Workers

2015

In 2007 the International Agency for Research on Cancer (IARC) classified shift work involving circadian disruption as a probable human carcinogen (1). Most of the evidence for this is based on animal experiment models and only a few reliable epidemiological studies. The cancer best described to date is breast cancer; this has mainly been investigated in female nurses and flight attendants (2, 3). Shift work can also increase the incidence of prostate cancer, as plausibly described in a review article published in 2012 (4). Mechanistically, it is possible that nocturnal light exposure and disrupted circadian rhythms cause cancer, or that tumor growth is favored by hormonal mediation. Noctur…

Metronomic Chemotherapy (mCHT) in HER2-ve Advanced Breast Cancer (ABC) Patients (PTS): When Care Objectives Meet Patients’ Need. Preliminary Results …

2017

Plasmatic Plasminogen Activator Inhibitor Activity in Patients with Primary Breast Cancer

1997

Tissue Polypeptide Antigen in Patients with Breast Cancer and Gynecological Cancer

1984

Abstract The serum concentrations of TPA were determined in 67 patients with primary breast cancer, in 70 patients with metastasizing breast carcinoma and in 20 patients with ovarian cancer of stages III and IV (FIGO). Elevated TPA levels (>85 U/L) were found in 54% of patients with primary breast cancer, in 81% of the cases with disseminated disease and in 86% of patients with an ovarian carcinoma stage III. Preoperative TPA values in patients with primary mammary cancer were found to correlate well with tumor size and axillary lymph node involvement. Perioperative course controls in 10 patients exhibited an increase of TPA serum levels. The observation of the patients with metastasizing b…

Post-therapeutic lymphedema in breast cancer

2019

Introductions. Lymphedema is an interstitial accumulation of protein-rich lymph fluid, due to the post-therapeutic alteration of lymphatic circulation in the upper limb. The appearance of lymphedema is favoured by a number of risk factors. All of these factors ultimately lead to a process of tissue fibrosis. Materials and methods. This study was carried out in an outpatient regimen, for a period of 12 months, in the kinetotherapy room, using massage elements for lymphatic drainage and kinetotherapy technique. The study group included 15 patients aged 27-65 years.Results and discutions. Patients evaluated the quality of life after surgery based on the physical and mental symptoms, which is w…

Patient Reported Outcome in metastatic breast cancer and platinum-resistant recurrent ovarian cancer treated with metronomic cyclophosphamide ± metho…

2021

A randomized study of tucatinib (ONT-380) vs. placebo in combination with capecitabine and trastuzumab in patients with pretreated HER2-pos. metastat…

2018

Oestrogen — Androgen Balance in Human Breast and Prostate Cancer

1980

Although we conventionally categorise the hormonal steroids as oestrogens, progestins, corticoids or androgens it is more realistic to consider that the steroids exhibit a continuous spectrum of biological effects.

Male Breast Cancer: Oncologic Surgery

2020

Many cases of male breast cancer (MBC) have been diagnosed during recent years. The increased incidence of such a mortal disease has pointed out the need for solid and well-defined protocols in order to obtain early diagnosis, effective treatment, as well as a greater long-term survival. Although many similarities with female breast cancer support similar diagnostic and therapeutic paths, recent findings about MBC cell phenotypes and tumor behavior support the need for a more customized ai, t, i, ar. One thing is though sure: nowadays lack of knowledge about MBC needs to stimulate further research and the introduction of more standardized and univocal diagnostic/therapeutic guidelines.

Circulating miR-99a-5p Expression in Plasma: A Potential Biomarker for Early Diagnosis of Breast Cancer

2020

MicroRNAs have emerged as new diagnostic and therapeutic biomarkers for breast cancer. Herein, we analysed miR-99a-5p expression levels in primary tumours and plasma of breast cancer patients to evaluate its usefulness as a minimally invasive diagnostic biomarker. MiR-99a-5p expression levels were determined by quantitative real-time PCR in three independent cohorts of patients: (I) Discovery cohort: breast cancer tissues (n = 103) and healthy breast tissues (n = 26)