Search results for "BSI"
showing 10 items of 468 documents
Neanderthal diets in central and southeastern Mediterranean Iberia
2013
During recent decades, Neanderthal diet has been a major research topic in palaeoanthropology. This has been accelerated by the maturation of different techniques, which have produced a plethora of new information. However, this proliferation of data has led to confusing and contradictory results. Furthermore, most of the ecological dietary studies have been carried out on specimens drawn from different time periods and regions, almost exclusively those characterized by cold, open environmental conditions. Subsistence models based on these fragmentary data have been applied to Neanderthals living in a variety of different regions and environments, even though their dietary strategies may ha…
Petrographic and spectroscopic (FT-IR) study of Western Mediterranean obsidians geological sources and of a lithic collection from Ustica Island (Sic…
2019
I n this study we applied petrochemical methods (SEM-EDS; FT-IR) in order to characterize a group of obsidian flakes collected at Ustica island (Sicily). Despite the absence of obsidian geological outcrops, a lot of obsidian fragments still emerging from the lands of Ustica testify that the island was a major import center of obsidian during the prehistory. On this island, there are some prehistoric settlements, dated from the Neolithic to the Middle Bronze Age (6000- 1200 BC), in which the use of obsidian continued until the beginning of metals age. Our study includes: i) Macroscopic and microscopic optical observations, which allowed selecting 18 obsidian flakes (starting from 50 obsidian…
Climate change and population dynamics during the late Mesolithic and the Neolithic transition in Iberia
2009
This paper explores how Early Holocene climate changes in the Western Mediterranean would have affected Late Mesolithic settlement distribution and subsistence strategies in Iberian Peninsula, thereby giving rise to various adaptive scenarios. The current radiocarbon data set concerning the Neolithisation process has revealed the rapidity of the spread of farming in Iberia. Considering both the implications of the last hunter-gatherers’ adaptation strategies and the population dynamics of agro-pastoral communities, we address the migration patterns underlying the Mesolithic- Neolithic transition. In conclusion, we propose that the initial colonization process was the result of two successiv…
Outbreak of infection with Klebsiella pneumoniae sequence type 258 producing Klebsiella pneumoniae Carbapenemase 3 in an intensive care unit in Italy
2010
Gram-negative pathogens producing carbapenemases represent an alarming clinical threat with serious effects on patient outcomes ([3][1], [7][2]). In 2001, Yigit et al. ([11][3]) reported a novel β-lactamase termed “ K lebsiella pneumoniae carbapenemase” (KPC-1) in North Carolina. KPC-producing
Ceftazidime-avibactam use for klebsiella pneumoniae carbapenemase-producing k. pneumoniae infections: A retrospective observational multicenter study
2021
Abstract Background A growing body of observational evidence supports the value of ceftazidime-avibactam (CAZ-AVI) in managing infections caused by carbapenem-resistant Enterobacteriaceae. Methods We retrospectively analyzed observational data on use and outcomes of CAZ-AVI therapy for infections caused by Klebsiella pneumoniae carbapenemase–producing K. pneumoniae (KPC-Kp) strains. Multivariate regression analysis was used to identify variables independently associated with 30-day mortality. Results were adjusted for propensity score for receipt of CAZ-AVI combination regimens versus CAZ-AVI monotherapy. Results The cohort comprised 577 adults with bloodstream infections (n = 391) or nonba…
NDM-1 and OXA-163 producing Klebsiella pneumoniae isolates in Cairo, Egypt, 2012
2013
Here we describe carbapenem resistance determinants in two Klebsiella pneumoniae isolates recovered from two hospitalised patients in the same intensive care unit of a cancer hospital in Cairo, Egypt. PCR and sequencing were used to detect and characterise β-lactamase genes. Clonal relationships between the isolates were analysed by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). The first K. pneumoniae isolate carried the blaNDM-1 gene and the second isolate carried the blaOXA-163 gene. Both isolates co-expressed the extended-spectrum β-lactamase CTX-M-15. The two isolates belonged to different sequence types (STs), ST11 and ST16, respectively. No history of …
Sequence type 101 (ST101) as the predominant carbapenem-non-susceptible Klebsiella pneumoniae clone in an acute general hospital in Italy.
2012
Klebsiella pneumoniae is one of the most common multidrug-resistant (MDR) Gram-negative organisms worldwide, responsible for high morbidity and mortality both in hospitals and alternative healthcare settings. Recently, increasing use of carbapenems has promoted the emergence and dissemination of carbapenem-non-susceptible MDR K. pneumoniae strains. All of the CNSKP strains isolated between January 2009 and December 2011 in the General Hospital of Prato (Prato, Italy) were studied. Our findings indicate that, unlike previously reported by other authors from different regions of Italy, K. pneumoniae producing KPC-2 and belonging to ST101 have been established in the area of Prato, Tuscany, It…
Is the monoclonal spread of the ST258, KPC-3-producing clone being replaced in southern Italy by the dissemination of multiple clones of carbapenem-n…
2015
D. M. Geraci, C. Bonura, M. Giuffre, L. Saporito, G. Graziano, A. Aleo, T. Fasciana, F. Di Bernardo, T. Stampone, D. M. Palma and C. Mammina 1) Department of Sciences for Health Promotion and Mother-Child Care ‘G. D’Alessandro’, University of Palermo, 2) Postgraduate Specialty School in Hygiene and Preventive Medicine, University of Palermo, 3) Laboratory of Microbiology, General Hospital ARNAS ‘Civico, Di Cristina & Benfratelli’, 4) Laboratory of Microbiology, General Hospital Azienda Ospedaliera ‘Villa Sofia-V, Cervello’ and 5) II Intensive Care Unit, General Hospital ARNAS ‘Civico, Di Cristina & Benfratelli’, Palermo, Italy
New β-Lactam-β-Lactamase Inhibitor Combinations.
2020
The limited armamentarium against drug-resistant Gram-negative bacilli has led to the development of several novel β-lactam-β-lactamase inhibitor combinations (BLBLIs). In this review, we summarize their spectrum of in vitro activities, mechanisms of resistance, and pharmacokinetic-pharmacodynamic (PK-PD) characteristics. A summary of available clinical data is provided per drug. Four approved BLBLIs are discussed in detail. All are options for treating multidrug-resistant (MDR) Enterobacterales and Pseudomonas aeruginosa Ceftazidime-avibactam is a potential drug for treating Enterobacterales producing extended-spectrum β-lactamase (ESBL), Klebsiella pneumoniae carbapenemase (KPC), AmpC, an…
LC-QTOF-MS and 1H NMR Metabolomics Verifies Potential Use of Greater Omentum for Klebsiella pneumoniae Biofilm Eradication in Rats
2020
Bacterial wound infections are a common problem associated with surgical interventions. In particular, biofilm-forming bacteria are hard to eradicate, and alternative methods of treatment based on covering wounds with vascularized flaps of tissue are being developed. The greater omentum is a complex organ covering the intestines in the abdomen, which support wound recovery following surgical procedures and exhibit natural antimicrobial activity that could improve biofilm eradication. We investigated changes in rats&rsquo