Search results for "Base"
showing 10 items of 8362 documents
Efficacy and safety of bempedoic acid for the treatment of hypercholesterolemia: A systematic review and meta-analysis
2020
Background Bempedoic acid is a first-in-class lipid-lowering drug recommended by guidelines for the treatment of hypercholesterolemia. Our objective was to estimate its average effect on plasma lipids in humans and its safety profile. Methods and findings We carried out a systematic review and meta-analysis of phase II and III randomized controlled trials on bempedoic acid (PROSPERO: CRD42019129687). PubMed (Medline), Scopus, Google Scholar, and Web of Science databases were searched, with no language restriction, from inception to 5 August 2019. We included 10 RCTs (n = 3,788) comprising 26 arms (active arm [n = 2,460]; control arm [n = 1,328]). Effect sizes for changes in lipids and high-…
Liver is not the unique site of synthesis of beta 2-glycoprotein I (apolipoprotein H): evidence for an intestinal localization.
1997
Apolipoprotein H is a protein of about 50 kilodaltons, structurally related to the regulators of the complement activation family. Its physiological function is poorly understood but it has been implicated in lipid metabolism and coagulative pathways. The major site of synthesis is thought to be the liver. Several reports indicate that apolipoprotein H is the antigen of the antiphospholipid antibodies and also behaves as an acute-phase reactant. Moreover, 40% of plasma apolipoprotein H is associated with very low-density lipoprotein, high-density lipoprotein, and postprandial chylomicrons. In this study we investigated other sites of synthesis by reverse transcription/polymerase chain react…
Genetic polymorphisms affecting the phenotypic expression in familial hypercholesterolemia
2004
The clinical expression of heterozygous familial hypercholesterolemia (FH) is highly variable even in patients carrying the same LDL receptor (LDL-R) gene mutation. This variability might be due to environmental factors as well as to modifying genes affecting lipoprotein metabolism. We investigated Apo E (2, 3, 4), MTP (-493G/T), Apo B (-516C/T), Apo A-V (-1131T/C), HL (-514C/T and -250G/A), FABP-2 (A54T), LPL (D9N, N291S, S447X) and ABCA1 (R219K) polymorphisms in 221 unrelated FH index cases and 349 FH relatives with defined LDL-R gene mutations. We found a significant and independent effect of the following polymorphisms on: (i) plasma LDL-C (Apo E, MTP and Apo B); (ii) plasma HDL-C (HL, …
Two Italian kindreds carrying the Arg136--Ser mutation of the Apo E gene: development of premature and severe atherosclerosis in the presence of epsi…
2003
Abstract Background and Aims: Type III hyperlipoproteinemia, or dysbetalipoproteinemia, is commonly associated with apolipoprotein E2 homozygosity (Cy Background and Aims: 12, Cy Background and Aims: 58). Apo E2-Christchurch (Arg136→Ser), a rare mutation of the Apo E gene, located in the receptor-binding domain of the protein, has been found to be associated in the vast majority of cases of dysbetalipoproteinemia. Methods and Results: This is the first report of two Italian kindreds carrying the Arg136→Ser mutation. One family is a four-generation kindred from Genoa (Liguria, Italy) with a high rate of mortality due to coronary artery disease: the proband was a 51-year-old woman with previo…
Quasisymmetric spheres over Jordan domains
2015
Let $\Omega$ be a planar Jordan domain. We consider double-dome-like surfaces $\Sigma$ defined by graphs of functions of $dist( \cdot ,\partial \Omega)$ over $\Omega$. The goal is to find the right conditions on the geometry of the base $\Omega$ and the growth of the height so that $\Sigma$ is a quasisphere, or quasisymmetric to $\mathbb{S}^2$. An internal uniform chord-arc condition on the constant distance sets to $\partial \Omega$, coupled with a mild growth condition on the height, gives a close-to-sharp answer. Our method also produces new examples of quasispheres in $\mathbb{R}^n$, for any $n\ge 3$.
Non-linear oscillators under parametric and external poisson pulses
1994
The extended Ito calculus for non-normal excitations is applied in order to study the response behaviour of some non-linear oscillators subjected to Poisson pulses. The results obtained show that the non-normality of the input can strongly affect the response, so that, in general, it can not be neglected.
Contrasting probabilistic and anti-optimization approaches in an applied mechanics problem
2003
Probabilistic and non-probabilistic, anti-optimization analyses of uncertainty are contrasted in this study. Specifically, the comparison of these two competing approaches is conducted for an uniform column, with initial geometric imperfection, subjected to an impact axial load. The reliability of the column is derived for the cases when the initial imperfections posses either (a) uniform probability density, (b) truncated exponential density or (c) generic truncated probability density. The problem is also analyzed in the context of an interval analysis. It is shown that in, the most important near-unity reliability range these two approaches tend to each other. Since the interval analysis…
Étude sur les réformes curriculaires par l'approche par compétences en Afrique
2009
Cette étude vise trois objectifs : réaliser un état des lieux des processus de réformes curriculaires en éducation de base en Afrique pour identifier les problèmes rencontrés, les résultats positifs et les "bonnes pratiques", aider les responsables des systèmes éducatifs à prendre des mesures pertinentes et accompagner les réformes et enfin aider les bailleurs de fonds à mieux comprendre les effets de leur aide et à mieux cibler les projets de réforme en termes de coût et d'efficacité à tous les niveaux des systèmes éducatifs impliqués.
Aprendizaje basado en proyectos para el desarrollo de las competencias profesionales del maestro: una propuesta de innovación docente desde la Didáct…
2015
Producción Científica
Evaluación de las actividades realizadas mediante la metodología de Aprendizaje Basado en Problemas
2020
[ES] La metodología de Aprendizaje Basado en Problemas (ABP) requiere un enfoque de evaluación en el que se evalúen una serie de competencias específicas y transversales. Esta evaluación debe de tener un carácter formativo que permita a los estudiantes identificar y corregir los errores a tiempo. Por lo tanto, es necesario disponer de herramientas para poder evaluar apropiadamente los resultados de aprendizaje y las competencias establecidas. En la asignatura de Corrosión de segundo de Máster de Ingeniería Química, el ABP se ha evaluado a través de un informe a entregar tras cada sesión de ABP, en donde se recogen las principales conclusiones tras la resolución cooperativa del problema plan…