Search results for "Base"

Phosphorylation of mismatch repair proteins MSH2 and MSH6 affecting MutSα mismatch-binding activity

2002

Mismatch repair (MMR) is involved in the removal of mispaired bases from DNA and thus plays an important role in the maintenance of genomic stability and the prevention of mutations and cancer. Moreover, MMR triggers genotoxicity and apoptosis upon processing of DNA lesions such as O6-methylguanine. Whereas the enzymology of MMR has been elucidated in great detail, only limited data are available concerning its regulation. Here we show that the major mismatch-binding proteins MSH2 and MSH6, forming the MutSalpha complex, are phosphorylated in vitro by protein kinase C and casein kinase II, but not by protein kinase A. Phosphorylation of MSH2 and MSH6 was also found within the cell, with MSH…

Cyclobutane Pyrimidine Photodimerization of DNA/RNA Nucleobases in the Triplet State

2010

The photoinduced formation of cyclobutane pyrimidine dimers in the triplet excited state of the DNA/RNA pyrimidine nucleobases pairs has been studied at the CASPT2 level of theory. A stepwise mechanism through the triplet state of the homodimer is proposed for the pairs of nucleobases cytosine, thymine, and uracil involving a singlet−triplet crossing intermediary structure of biradical character representing the most favorable triplet state conformation of the nucleobases as found in the DNA environment. The efficiency of the mechanism will be modulated by two factors: the effectiveness of the triplet−triplet energy transfer process from a donor photosensitizer molecule, which relates to th…

Improving Docking Performance Using Negative Image-Based Rescoring

2018

Despite the large computational costs of molecular docking, the default scoring functions are often unable to recognize the active hits from the inactive molecules in large-scale virtual screening experiments. Thus, even though a correct binding pose might be sampled during the docking, the active compound or its biologically relevant pose is not necessarily given high enough score to arouse the attention. Various rescoring and post-processing approaches have emerged for improving the docking performance. Here, it is shown that the very early enrichment (number of actives scored higher than 1% of the highest ranked decoys) can be improved on average 2.5-fold or even 8.7-fold by comparing th…

La segnalazione delle reazioni avverse da farmaci in oncologia: considerazioni di base e analisi dell'esperienza organizzativa e scientifica nella Re…

2011

Käytössä kehittyvä kieli : paikat ja tilat suomi toisena kielenä -oppijoiden teksteissä

2015

Variation and variability in L2 learning trajectories : Learning the Finnish existential construction

2022

Taking an onomasiological approach and a dynamic usage-based perspective, this study explores how four beginning L2 learners of Finnish develop in expressing existentiality (‘there is something somewhere’) before and after instruction. Data were collected weekly over a period of nine months and examined for conventionalized and non-conventionalized constructions that express existentiality. As expected from a dynamic usage-based perspective, both inter-individual variation and intra-individual variability were identified. The initial repertoires of two of the learners were quite variable, as they used several different non-conventionalized constructions before settling on more conventionali…

Expertise and becoming conscious of something

2022

Becoming conscious refers to how new mental content emerges in the mind. To understand this phenomenon, we studied how people experience graffiti by thinking aloud. In protocols, we found three types of becoming conscious: experiencing emotional and perceptual content directly linked to a perceivable object, non-perceivable or apperceived information content, and transformation and restructuring processes. On the grounds of the content-based study of protocols, we suggest that people can become conscious of either direct perception, apperception, or restructuring thinking. Research of the mind, which is grounded in analysis and explained by properties of mental content, can be called conten…

Integration of CSR into CEOs’ compensation: effects on social and financial performance of French listed firms

2023

Based on the stakeholder model of corporate governance, this research analyzes the relationship between the integration of corporate social responsibility (CSR) into CEO compensation and corporate social and financial performance, in firms listed on France’s SBF 120 stock market between 2015 and 2019. The results of panel data regressions show that indexing CEO compensation on CSR criteria only influence corporate social performance Moreover, social performance has a positive impact on financial performance and a mediating effect between the integration of CSR criteria into CEO compensation and financial performance.

Lexical verbs for medical professionals

2019

In recent years, English has become the lingua franca of medicine and the language teaching profession has seen the emergence of im- plementing English for Medical Purposes (EMP) courses. The needs of EMP learners are very specific and EMP teachers who are language experts and not medical ones need to develop materials that are in line with EMP learners’ specific needs. In response to recognizing EMP students’ needs, extensive corpus-based research has led to specialized medical wordlists (Chen and Ge 2007; Wang, Liang, Ge 2008; Mungra and Canziani 2013; Hsu 2013; Lei and Liu 2016). Such wordlists have given instructors the opportunity to focus on specific vocabulary facil- itating domain s…

Tulkošanas stratēģijas Valsts Centrālās bankas gada pārskata ievadā

2020

Finanšu tulkošana ir ļoti sarežģīts un augsti pieprasīts mūsdienās specializētās tulkošanas veids, kura kvalitāte ir cieši saistīta ar pareizu tulkošanas stratēģiju un rīku izvēli. Lai identificētu tulkošanas pieejas un stratēģijas, kas ir ieteicamās konkrētajā specializētās valodas apakš-žanrā, ir svarīgi izanalizēt labākus šī apakš-žanra tulkojumus. Šī maģistra darba mērķis – ir izpētīt tulkošanas stratēģijas, kas ir visbiežāk pielietotās konkrētā finanšu tulkojumu apakš-žanrā – Valsts Centrālās bankas gada pārskata ievadā. Pētāmo tekstu korpuss tika sastādīts no tādu valsts banku un starptautisko finanšu institūciju kā LB, CBR, ECB un EBRD gada pārskatiem, laika periodā no 2009. līdz 201…