Search results for "Basic Research"
showing 10 items of 76 documents
Overcoming the “lost before translation” problem: An exploratory study
2019
This paper draws on Stokes’ (1997) framework to position the disconnection between theory and practice as a knowledge production problem. In this sense, we argue that a better understanding of different academic profiles is extremely important to focus efforts on those academics that may overcome the ‘lost before translation’ problem. Our data, that come from a survey of researchers affiliated to the Spanish National Research Council (CSIC), provide a good opportunity to explore the factors that might increase or impede the likelihood that researchers engage in research that reconciles the quest for fundamental understanding with the consideration of use (Pasteur’s profile), rather than in …
History of echinostomes (Trematoda)
2014
AbstractEchinostomatidae (Trematoda) is the largest family within the class Trematoda. Members of this family have been studied for many years in relation to their utility as basic research models in biodiversity and systematics and also as experimental models in parasitology since they offer many advantages. Echinostomes have contributed significantly to numerous developments in many areas studied by parasitologists and experimental biologists. In this review, we examine the history of the echinostomebased studies from the beginnings to the present. For this purpose, we have divided the history of echinostomes into four periods (i.e. 18th and 19th centuries, first half of the 20th century,…
Visions for regenerative medicine: interface between scientific fact and science fiction.
2006
This article gives a brief overview of the authors' views on the future development of tissue engineering with respect to the challenges both to the materials and life sciences. Emphasis will be placed on the advantages of three-dimensional bioresorbable polymers in combination with relevant molecular cues and the application of autologous stem or progenitor cells. There is a requirement for much more diversity in the synthesis of so-called "intelligent" materials, which respond to external stimuli, as well as the development of novel drug and gene delivery systems. In addition, much more basic research is necessary in developmental biology and the application of modern cell and molecular b…
Depletion ofL-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes
2012
PMCID: PMC3494587
Communiquer sur le goût, du discours à la méthode
2013
Based on the original scientific field of taste communication, the article exposes the setting up of a methodology specific to the communication sciences. Explicating the specificity of the taste and using multidisciplinary tools, we build a communication methodology specific to the communication of sensory attribute.
Oxidative Stress in COPD.
2019
Numerous studies over the years have shown that oxidative stress plays a major role in the development of the disease. Oxidative stress involvement in COPD opens up the possibility of using antioxidant therapies in the treatment of the disease. However, so far, these therapies have shown no clinical benefit indicating that more basic research efforts are needed to understand the underlying mechanisms by which oxidative stress leads to the development of COPD.
Opioid Poorly-Responsive Cancer Pain. Part 2
2001
Basic research in experimental pain models may illuminate the phenomenon of cancer pain that is poorly responsive to opioid drugs. Research findings can be valuable in formulating new strategies in clinical practice. This review evaluated experimental observations in terms of the events that occur in cancer patients receiving opioid therapy for pain.
Intraperitoneal adhesions-an ongoing challenge between biomedical engineering and the life sciences
2011
Peritoneal adhesions remain a relevant clinical problem despite the currently available prophylactic barrier materials. So far, the physical separation of traumatized serosa areas using barriers represents the most important clinical strategy for adhesion prevention. However, the optimal material has not yet been found. Further optimization or pharmacological functionalization of these barriers could give an innovative input for peritoneal adhesion prevention. Therefore, a more complete understanding of pathogenesis is required. On the basis of the pathophysiology of adhesion formation the main barriers currently in clinical practice as well as new innovations are discussed in the present r…
In-house versus external basic research and first-to-market innovations
2016
This paper explores to what extent conducting internal basic research, as opposed to external basic research (i.e. outsourcing and collaboration with universities) encourages firms to bring new products into the market ahead of competitors, and contributes to innovation performance. The analysis is based on a sample of Spanish manufacturing firms over the period 2006–2012. Our findings suggest that conducting in-house basic research affects firm's propensity to introduce product novelties. Furthermore, performing this activity continuously affects the probability of being product-pioneer in low and medium–low tech sectors. Collaboration with universities also helps in introducing new produc…
Combinatorial chemistry of -hairpins
2000
Combinatorial chemistry is expanding rapidly both in terms of chemistry development and application to the synthesis of compound libraries for lead discovery and optimization. Combinatorial technologies continue evolving and developing, in fact they are being used as basic research tools in different fields that include peptide/protein folding. This review examines the use of combinatorial chemistry in the design of peptides and protein domains that adopt beta-sheet conformations. In particular, the use of conformationally restricted peptide libraries has allowed the identification of linear peptides that are folded in a beta-hairpin structure in plain aqueous solutions.