Search results for "Bax"
showing 10 items of 25 documents
Restricted 123-avoiding Baxter permutations and the Padovan numbers
2007
AbstractBaxter studied a particular class of permutations by considering fixed points of the composite of commuting functions. This class is called Baxter permutations. In this paper we investigate the number of 123-avoiding Baxter permutations of length n that also avoid (or contain a prescribed number of occurrences of) another certain pattern of length k. In several interesting cases the generating function depends only on k and is expressed via the generating function for the Padovan numbers.
Docker pielietošana darbvirsmas nolūkiem
2021
Maģistra darba mērķis ir izpētīt Docker pielietošanas iespējas darbvirsmas nolūkiem. Tas sniegtu Docker priekšrocības – izolācija, pārnesamība, stabilitāte – darbvirsmas lietojumiem, tādiem kā interneta pārlūkošana, darbs ar dokumentiem vai 3D datorspēles. Atšķirībā no virtualizācijas, šīs priekšrocības nāk bez lieliem veiktspējas zudumiem. Maģistra darbā tiek apskatītas un novērtētas iespējas grafisko lietotņu palaišanai un izmantošanai Docker konteineros uz GNU/Linux un Windows platformām. Tiek veikti veiktspējas un patērēto resursu salīdzinājumi ar pa tiešo uzinstalētām programmām un virtuālajām mašīnām. Tiek lietots x11Docker ietvars un MobaXterm lietotņu attēlošanai. Rezultātā ir iegūt…
Consensus guidelines for the detection of immunogenic cell death
2014
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit immune responses specific for dead cell-associated antigens. However, multiple stimuli can trigger a functionally peculiar type of apoptotic demise that does not go unnoticed by the adaptive arm of the immune system, which we named "immunogenic cell death" (ICD). ICD is preceded or accompanied by the emission of a series of immunostimulatory damage-associated molecular patterns (DAMPs) in a precise spatiotemporal configuration. Several anticancer agents that have been successfully employed in the clinic for decades, including various chemotherapeutics and radiotherapy, can elicit ICD. Moreover, defect…
Glassy PEEK‐WC vs Rubbery Pebax®1657 Polymers: Effect on the Gas Transport in CuNi‐MOF Based Mixed Matrix Membranes
2020
Mixed matrix membranes (MMMs) are seen as promising candidates to overcome the fundamental limit of polymeric membranes, known as the so-called Robeson upper bound, which defines the best compromise between permeability and selectivity of neat polymeric membranes. To overcome this limit, the permeability of the filler particles in the MMM must be carefully matched with that of the polymer matrix. The present work shows that it is not sufficient to match only the permeability of the polymer and the dispersed phase, but that one should consider also the individual contributions of the diffusivity and the solubility of the gas in both components. Here we compare the gas transport performance o…
Yang-Baxter equation and reflection equations in integrable models
1996
The definitions of the main notions related to the quantum inverse scattering methods are given. The Yang-Baxter equation and reflection equations are derived as consistency conditions for the factorizable scattering on the whole line and on the half-line using the Zamolodchikov-Faddeev algebra. Due to the vertex-IRF model correspondence the face model analogue of the ZF-algebra and the IRF reflection equation are written down as well as the $Z_2$-graded and colored algebra forms of the YBE and RE.
Bax Inhibitor-1-mediated Ca2+ leak is decreased by cytosolic acidosis
2013
Bax Inhibitor-1 (BI-1) is an evolutionarily conserved six-transmembrane domain endoplasmic reticulum (ER)-localized protein that protects against ER stress-induced apoptotic cell death. This function is closely connected to its ability to lower steady-state ER Ca2+ levels. Recently, we elucidated BI-1's Ca(2+)-channel pore in the C-terminal part of the protein and identified the critical amino acids of its pore. Based on these insights, a Ca(2+)-channel pore-dead mutant BI-1 (BI-1(D213R)) was developed. We determined whether BI-1 behaves as a bona fide H+/Ca2+ antiporter or as an ER Ca(2+)-leak channel by investigating the effect of pH on unidirectional Ca(2+)-efflux rates. At pH 6.8, wild-…
Optogenetically Controlled Activity Pattern Determines Survival Rate of Developing Neocortical Neurons
2021
A substantial proportion of neurons undergoes programmed cell death (apoptosis) during early development. This process is attenuated by increased levels of neuronal activity and enhanced by suppression of activity. To uncover whether the mere level of activity or also the temporal structure of electrical activity affects neuronal death rates, we optogenetically controlled spontaneous activity of synaptically-isolated neurons in developing cortical cultures. Our results demonstrate that action potential firing of primary cortical neurons promotes neuronal survival throughout development. Chronic patterned optogenetic stimulation allowed to effectively modulate the firing pattern of single ne…
Bax inhibitor-1 is likely a pH-sensitive calcium leak channel, not a H+/Ca2+ exchanger.
2014
The endoplasmic reticulum (ER) plays a key role in the synthesis, folding, and sorting of proteins, and disturbances of this delicate system can cause cell death. The ER also serves as the major intracellular calcium (Ca(2+)) store, and release of Ca(2+) from this store controls diverse cellular functions. At the interface of both these functions of the ER is Bax inhibitor-1 (BI-1), an evolutionarily conserved multifunctional protein that mediates Ca(2+) efflux from the ER and protects against ER stress. Several mechanisms have been proposed to explain how BI-1 might mediate Ca(2+) efflux from the ER. Chang et al. present structural evidence that a bacterial homolog of BI-1, BsYetJ, is a pH…
Transmembrane BAX Inhibitor-1 Motif Containing Protein 5 (TMBIM5) Sustains Mitochondrial Structure, Shape, and Function by Impacting the Mitochondria…
2020
The Transmembrane Bax Inhibitor-1 motif (TMBIM)-containing protein family is evolutionarily conserved and has been implicated in cell death susceptibility. The only member with a mitochondrial localization is TMBIM5 (also known as GHITM or MICS1), which affects cristae organization and associates with the Parkinson&rsquo