Search results for "Bile"

Synthesis of new, UV-photoactive dansyl derivatives for flow cytometric studies on bile acid uptake.

2009

Four new fluorescent derivatives of cholic acid have been synthesized; they incorporate a dansyl moiety at 3 alpha-, 3 beta-, 7 alpha- or 7 beta- positions. These cholic acid analogs are UV photoactive and also exhibit green fluorescence. In addition, they have been demonstrated to be suitable for studying the kinetics of bile acid transport by flow cytometry.

Facile synthesis of 5β-cholane-sym-triazine conjugates starting from metformin and bile acid methyl esters: Liquid and solid state NMR characterizati…

2009

Abstract Four bile acid-triazine conjugates: N2′,N2′-dimethyl-6′-(3α-hydroxy-5β-24-norcholyl)-1′,3′,5′-triazine-2′,4′-diamine (lithocholyl triazine, 4a), N2′,N2′-dimethyl-6′-(3α,7α-dihydroxy-5β-24-norcholyl)-1′,3′,5′-triazine-2′,4′-diamine (chenodeoxycholyl triazine, 4b), N2′,N2′-dimethyl-6′6′-(3α,12α-dihydroxy-5β-24-norcholyl)-1′,3′,5′-triazine-2′,4′-diamine (deoxycholyl triazine) (4c), and N2′,N2′-dimethyl-6′-(3α,7α,12α-trihydroxy-5β-24-norcholyl)-1′,3′,5′-triazine-2′,4′-diamine (cholyl triazine) (4d) have been prepared and characterized by liquid and solid state NMR. An improved synthetic method produced better yields and an easier purification procedure for 4d than reported in the liter…

Supramolecular Adducts of Ferrocene and Five Bile Acid Derived Triolides

1997

Formation of supramolecular adducts of ferrocene (guest) and cyclic head-to-tail trimers (hosts) derived from bile acid: 3α-hydroxy-5β-cholan-24-oic acid triolide (1), 3α-hydroxy-7-oxo-5β-cholan-24-oic acid triolide (2), 3α-hydroxy-12-oxo-5β-cholan-24-oic acid triolide (3), 3α-hydroxy-7α-trifluoroacetoxy-6β-cholan-24-oic acid triolide (4) and 3α-hydroxy-12α-TFA-5β-cholan-24-oic acid triolide (5) (TFA = trifluoroacetoxy) have been studied by 1H NMR. The best computer-assisted data fitting on the 1H-NMR chemical shift data was given by a 1:2 (guest/host) association model. The association constants vary in the range 170–990 M−1, 7-oxo-substituted triolide 2 and 12α-TFA triolide 5 showing the …

Solid state structural studies of five bile acid derivatives

2008

Five synthetically important bile acid derivatives have been characterized by 13 C CP-MAS, X-ray diffraction (both single crystal and powder), FTIR, and thermoanalytical (DSC and TG) methods. The crystallinity of all these derivatives is high, which can be deducted from the 13 C CP-MAS and powder X-ray diffraction data. Two of the compounds showed polymorphism, and one polymorph was structurally elucidated for both by comparing single crystal and powder X-ray diffraction data.

Correlation of Tumor Density Changes on CT with 18FDG PET Activity for Response Assessment in Advance Bile Duct Cancer

2009

Common bile duct stones in cholecystectomized patients (chapt. 28) in Biliary lithiasis Basic science, current diagnostic and therapeutic approaches …

2008

The incidence of retained or primary stones is approximately 2-5% after LC and 5-15% after common bile duct exploration: in principle, these patients are in need of further intervention. Residual common bile stones are called secondary when they originate in gallbladder and later pass down through the cystic duct into the common bile duct.

PENTAZOCINE HAMPERS BILE FLOW

1985

Gallenr�ckflu� und Leberzelle

1966

TarSynFlow, a workflow for bacterial genome comparisons that revealed genes putatively involved in the probiotic character of Shewanella putrefaciens…

2019

Probiotic microorganisms are of great interest in clinical, livestock and aquaculture. Knowledge of the genomic basis of probiotic characteristics can be a useful tool to understand why some strains can be pathogenic while others are probiotic in the same species. An automatized workflow called TarSynFlow (Targeted Synteny Workflow) has been then developed to compare finished or draft bacterial genomes based on a set of proteins. When used to analyze the finished genome of the probiotic strain Pdp11 ofShewanella putrefaciensand genome drafts from seven known non-probiotic strains of the same species obtained in this work, 15 genes were found exclusive of Pdp11. Their presence was confirmed …

Poloxamer/sodium cholate co-formulation for micellar encapsulation of Doxorubicin with high efficiency for intracellular delivery: an in-vitro bioava…

2020

Abstract Hypothesis Doxorubicin hydrochloride (DX) is widely used as a chemotherapeutic agent, though its severe side-effects limit its clinical use. A way to overcome these limitations is to increase DX latency through encapsulation in suitable carriers. However, DX has a high solubility in water, hindering encapsulation. The formulation of DX with sodium cholate (NaC) will reduce aqueous solubility through charge neutralization and hydrophobic interactions thus facilitating DX encapsulation into poloxamer (F127) micelles, increasing drug latency. Experiments DX/NaC/PEO-PPO-PEO triblock copolymer (F127) formulations with high DX content (DX-PMs) have been prepared and characterized by scat…