Search results for "Bioactive compound"

Chemical Composition, In Vitro Bioaccessibility and Antioxidant Activity of Polyphenolic Compounds from Nutraceutical Fennel Waste Extract

2021

Fennel (Foeniculum vulgare Mill.) waste contains a broad range of bioactive molecules, including polyphenols, which have poor bioaccessibility during gastrointestinal digestion. This work aimed to investigate the bioaccessibility of total phenolic compounds and the antioxidant capacity during simulated gastrointestinal digestion using two nutraceutical formulations based on non-acid-resistant (NAR) and acid-resistant (AR) capsules containing aqueous-based extracts from fennel waste. Moreover, to obtain a comprehensive investigation of the polyphenolic constituents of the fennel waste extract, a high-resolution mass spectrometry (Q-Orbitrap) analysis was performed. Notably, chlorogenic acids…

Factors that influence the quality of metabolomics data in in vitro cell toxicity studies: a systematic survey

2021

Abstract REACH (Registration, Evaluation, Authorization and Restriction of Chemicals) is a global strategy and regulation policy of the EU that aims to improve the protection of human health and the environment through the better and earlier identification of the intrinsic properties of chemical substances. It entered into force on 1st June 2007 (EC 1907/2006). REACH and EU policies plead for the use of robust high-throughput "omic" techniques for the in vitro investigation of the toxicity of chemicals that can provide an estimation of their hazards as well as information regarding the underlying mechanisms of toxicity. In agreement with the 3R’s principles, cultured cells are nowadays wide…

Tillage and crop sequence effects on productivity and technological and nutritional quality of durum wheat

2015

We report data from two consecutive growing seasons {2012/13 and 2013/14, i.e., after 21-22 years of continuous application of the treatments) on grain yield and some technological and nutritional quality parameters of durum wheat. On average, grain yield was higher with CT than NT, but the effects of tillage varied greatly by crop sequence. On average, NT caused a decrease in both grain protein and gluten contents with respect to CT when wheat was grown after faba bean, whereas no differences between NT and CT were observed for these traits for continuous wheat or berseem clover. Significant interactions between tillage system and crop sequence were observed for alveographic parameters and…

Extraction of bioactive compounds from shrimp waste for nutraceutical application

2015

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Bioactive compounds from marine resources of western Sicily.

2009

Bioactive Azoles with Three Heteroatoms

2010

This issue is dedicated to scientists belonging to either or both the fields of heterocyclic and medicinal chemistry. Nowadays, pharmaceutical industries are more and more dedicating their research towards different use or applications of the same molecule rather than towards the development of new drugs. In the latter decades, in fact, the time which is necessary since a given molecule is synthesized to when it is approved as a drug has significantly increased. Therefore, the development of time-saving methodologies such as combinatorial chemistry and computationally driven drug design has attracted the interest of several organic and medicinal chemists. Many of the molecules tested in-vit…

Phytochemical characterization and antioxidant activity of the aerial part extracts from two species of Matthiola wild in Sicily: Matthiola sinuata a…

2022

As part of a project aimed at investigating the specific and intraspecific taxa of Matthiola which grow spontaneously in Sicily (Italy), in this work our research has been focused on Matthiola tricuspidata and Matthiola sinuata. The phenolic and volatile compounds of the hydroalcoholic extracts from the aerial parts of the selected species have been characterized by HPLC-PDA/ESI-MS and SPME-GC/MS analyses. Moreover, the antioxidant capacity in vitro (1,1-diphenyl-2-picrylhydrazil (DPPH), reducing power and Fe2+ chelating activity assays) and the toxicity (Artemia salina lethality bioassay) of the extracts were investigated. The phytochemical analyses highlighted quite different phenolic and…

Antibacterial effect of the bioactive compound beauvericin produced by Fusarium proliferatum on solid medium of wheat.

2010

To obtain the bioactive compound beauvericin (BEA), Fusarium proliferatum CECT 20569 was grown on a solid medium of wheat, utilizing the technique of the solid state fermentation (SSF), being this mycotoxin purified by high performance liquid chromatography (HPLC) with a reverse phase semi-preparative column using as the mobile phase acetonitrile/water in gradient condition. The purity of the BEA was verified by analytical HPLC and liquid chromatography tandem mass spectrometry (LC/MS-MS). The pure fractions of BEA were utilized to determinate the antibiotic effects on several bacterial strains that are considered normally pathogens of the intestinal tract as: Escherichia coli, Enterococcus…

Bacterial growth and biological properties of Cymbopogon schoenanthus and Ziziphus lotus are modulated by extraction conditions

2020

Abstract The present study aims to evaluate the antibacterial activity and biological properties of two traditional Saharian plants (Cymbopogon schoenanthus and Ziziphus lotus). The plant extracts were obtained by using a different combination of extraction methods (conventional vs. ultrasound-assisted) and solvents (water vs. ethanol:water (50:50, v/v)). The antioxidant profile, anti-inflammatory activity and impact on bacterial growth (foodborne and probiotic bacteria) of the obtained extracts were assessed. The plant species showed the hierarchically more important role in determining the biological properties of the extracts, followed by extraction solvent and extraction conditions. Con…

Antimalarial activity of abietane ferruginol analogues possessing a phthalimide group.

2014

The abietane-type diterpenoid (+)-ferruginol, a bioactive compound isolated from New Zealand’s Miro tree (Podocarpus ferruginea), displays relevant pharmacological properties, including antimicrobial, cardioprotective, anti-oxidative, anti-plasmodial, leishmanicidal, anti-ulcerogenic, anti-inflammatory and anticancer. Herein, we demonstrate that ferruginol (1) and some phthalimide containing analogues 2–12 have potential antimalarial activity. The compounds were evaluated against malaria strains 3D7 and K1, and cytotoxicity was measured against a mammalian cell line panel. A promising lead, compound 3, showed potent activity with an EC50 = 86 nM (3D7 strain), 201 nM (K1 strain) and low cyto…