Search results for "Bioengineering"
showing 10 items of 1963 documents
Transcatheter Heart Valve Implantation in Bicuspid Patients with Self-Expanding Device
2021
Bicuspid aortic valve (BAV) patients are conventionally not treated by transcathether aortic valve implantation (TAVI) because of anatomic constraint with unfavorable outcome. Patient-specific numerical simulation of TAVI in BAV may predict important clinical insights to assess the conformability of the transcathether heart valves (THV) implanted on the aortic root of members of this challenging patient population. We aimed to develop a computational approach and virtually simulate TAVI in a group of n.6 stenotic BAV patients using the self-expanding Evolut Pro THV. Specifically, the structural mechanics were evaluated by a finite-element model to estimate the deformed THV configuration in …
A Nanoparticulate Drug-Delivery System for Rivastigmine: Physico-Chemical and in vitro Biological Characterization
2007
The preparation and characterization of surface-PEGylated polymeric nanoparticles are described. These systems were obtained by UV irradiation of PHM and PHM-PEG 2000 as an inverse microemulsion, using an aqueous solution of the PHM/PHM-PEG 2000 copolymer mixture as the internal phase and triacetin saturated with water as the external phase, and characterized by dimensional analysis, zeta-potential measurements and XPS. in vitro biological tests demonstrated their cell compatibility and their ability to escape from phagocytosis. Rivastigmine was encapsulated into the nanoparticle structure and drug-release profiles from loaded samples were investigated in PBS at pH = 7.4 and human plasma.
Dielectric Behavior of Aqueous Solutions of α,β-Poly(aspartyl hydrazide) and α,β-Poly(N-hydroxyethyl aspartamide): An Investigation of the Structural…
1994
The dielectric properties of aqueous solutions of α,β-poly(aspartyl hydrazide) (PAHy) and of α,β-poly( N-hydroxyethyl aspartamide) (PHEA) were measured at 25 ° C in the frequency range of 100 MHz to 15 GHz using a time domain reflection method (TDR). Single time relaxation processes were found at 2 GHz and 15 GHz, respectively. The low frequency dispersion was inter preted in terms of the dynamics of polymeric segments based on the dielectric relaxation strength and the relaxation time. The high frequency process which is attributed to the rotational relaxation of water, indicated that water mole cules surrounding the polymeric backbone and in the pure state have a similar rotational behav…
Shell matrices of recent rhynchonelliform brachiopods: microstructures and glycosylation studies.
2007
ABSTRACTLike most metazoan biomineralisations, the brachiopod shell is the end product of a biologically controlled calcification process. The main agent of the control is the extracellular matrix, which is secreted by the outer mantle epithelium. This matrix mediates the calcification process by allowing crystal nucleation and elongation in specific orientations and finally, by stopping crystal growth. The proteinaceous moiety of brachiopod shell matrices has been extensively studied. Less known are the post-translational modifications that occur in these matrices, in particular glycosylations. In this comparison of five species of Recent articulated brachiopods, the ratio of soluble to in…
Dependence of O2 diffusion dynamics on pressure and temperature in silica nanoparticles
2013
An experimental study of the molecular O2 diffusion process in high purity non-porous silica nanoparticles having 50 m2/g BET specific surface and 20 nm average radius was carried out in the temperature range from 127 to 177 °C at O2 pressure in the range from 0.2 to 66 bar. The study was performed by measuring the volume average interstitial O2 concentration by a Raman and photoluminescence technique using a 1,064 nm excitation laser to detect the singlet to triplet emission at 1,272 nm of the molecular oxygen in silica. A dependence of the diffusion kinetics on the O2 absolute pressure, in addition to temperature dependence, was found. The kinetics can be fit by the solution of Fick’s dif…
Analysis of the Effectiveness of Arytenoidectomy and Posterior Cordectomy with the Use of CFD Airflow Measurements in Patients with BVFP: A Retrospec…
2022
Purpose. Bilateral vocal fold paralysis (BVFP) is a rare larynx disease manifested by dyspnea, which often requires surgical treatment. The aim of the study is to determine the effectiveness of unilateral arytenoidectomy with posterior cordectomy in the treatment of BVFP using the computational fluid dynamics (CFD) method. Methods. This study included 33 patients with BVFP who underwent unilateral laser arytenoidectomy with posterior cordectomy. Glottis area measurements and spirometry, as well as a self-assessment of respiratory efficiency were performed before the surgery and after the recovery period. Using the CFD method, computer models of the glottis were made. Then, changes in air pr…
Blockchain-Based Land Registration System: A Conceptual Framework
2022
Land registration authorities are frequently held accountable for the alleged mismanagement and manipulation of land records in various countries. Pakistan’s property records are especially vulnerable to falsification and corruption because of the country’s poverty. Different parties therefore claim varying degrees of authority over a specific piece of land. Given the fact that this data has been consolidated, it has become significantly more vulnerable to security threats. The goal of decentralized system research has been to increase the reliability of these systems. In order to fix the flaws of centralized systems, blockchain-based decentralized systems are currently in development. By u…
An Effective Approach for Human Activity Classification Using Feature Fusion and Machine Learning Methods
2022
Recent advances in image processing and machine learning methods have greatly enhanced the ability of object classification from images and videos in different applications. Classification of human activities is one of the emerging research areas in the field of computer vision. It can be used in several applications including medical informatics, surveillance, human computer interaction, and task monitoring. In the medical and healthcare field, the classification of patients’ activities is important for providing the required information to doctors and physicians for medication reactions and diagnosis. Nowadays, some research approaches to recognize human activity from videos and images ha…
In vitro assessment of a novel additive manufactured titanium implant abutment
2021
Background Dental implant temporization remains a clinical challenge. A novel abutment simplifying the procedure was developed, but conventional fabrication was costly and unpredictable. A workflow was developed to fabricate the novel abutment using additive manufacturing. This in vitro investigation assessed the additive manufactured (AM) novel abutments to conventionally manufactured (CM) abutments. Material and methods The AM abutments were fabricated in dental-grade titanium (Ti-6Al-4V) using Selective Laser Melting and were post-processed. The CM abutments were milled and subsequently laser welded manually. Pin strength of the abutments was assessed using a universal loading machine. T…
Fabrication of layered nanostructures by successive electron beam induced deposition with two precursors: protective capping of metallic iron structu…
2011
We report on the stepwise generation of layered nanostructures via electron beam induced deposition (EBID) using organometallic precursor molecules in ultra-high vacuum (UHV). In a first step a metallic iron line structure was produced using iron pentacarbonyl; in a second step this nanostructure was then locally capped with a 2-3 nm thin titanium oxide-containing film fabricated from titanium tetraisopropoxide. The chemical composition of the deposited layers was analyzed by spatially resolved Auger electron spectroscopy. With spatially resolved x-ray absorption spectroscopy at the Fe L₃ edge, it was demonstrated that the thin capping layer prevents the iron structure from oxidation upon e…