Search results for "Biomedical engineering"
showing 10 items of 2020 documents
Evaluation of Effects of Various Irrigating Solutions on Chemical Structure of Root Canal Dentin Using FTIR, SEM, and EDS: An In Vitro Study
2022
Background: Sequential chemical application for irrigating a root canal during chemomechanical debridement can affect the dentin microstructure. Understanding the effects of various irrigants on chemical properties of dentin can elucidate their effects on physical properties and thereby explain the higher incidence of structural failure in endodontically treated teeth. This in vitro research aimed to compare and evaluate the effects of three different irrigating solutions on the chemical structure of root canal dentin in extracted human teeth. Methods: Forty-eight extracted single-rooted mandibular premolar teeth were sectioned at the cemento–enamel junction by a diamond disc and were…
Dynamic Responsive Inguinal Scaffold Activates Myogenic Growth Factors Finalizing the Regeneration of the Herniated Groin
2022
Background: Postoperative chronic pain caused by fixation and/or fibrotic incorporation of hernia meshes are the main concerns in inguinal herniorrhaphy. As inguinal hernia is a degenerative disease, logically the treatment should aim at stopping degeneration and activating regeneration. Unfortunately, in conventional prosthetic herniorrhaphy no relationship exists between pathogenesis and treatment. To overcome these incongruences, a 3D dynamic responsive multilamellar scaffold has been developed for fixation-free inguinal hernia repair. Made of polypropylene like conventional flat meshes, the dynamic behavior of the scaffold allows for the regeneration of all typical inguinal components: …
Titanium Lattice Structures Produced via Additive Manufacturing for a Bone Scaffold: A Review
2023
The progress in additive manufacturing has remarkably increased the application of lattice materials in the biomedical field for the fabrication of scaffolds used as bone substitutes. Ti6Al4V alloy is widely adopted for bone implant application as it combines both biological and mechanical properties. Recent breakthroughs in biomaterials and tissue engineering have allowed the regeneration of massive bone defects, which require external intervention to be bridged. However, the repair of such critical bone defects remains a challenge. The present review collected the most significant findings in the literature of the last ten years on Ti6Al4V porous scaffolds to provide a comprehensive summa…
Low-fouling, mixed-charge poly-L-lysine polymers with anionic oligopeptide side-chains
2018
Biosensors and biomedical devices require antifouling surfaces to prevent the non-specific adhesion of proteins or cells, for example, when aiming to detect circulating cancer biomarkers in complex natural media (e.g., in blood plasma or serum). A mixed-charge polymer was prepared by the coupling of a cationic polyelectrolyte and an anionic oligopeptide through a modified "grafting-to" method. The poly-l-lysine (PLL) backbone was modified with different percentages (y%) of maleimide-NHS ester chains (PLL-mal(y%), from 13% to 26%), to produce cationic polymers with specific grafting densities, obtaining a mixed-charge polymer. The anionic oligopeptide structure (CEEEEE) included one cysteine…
The Application of Machine Learning Algorithms to the Analysis of Electromyographic Patterns From Arthritic Patients
2009
The main aim of our study was to investigate the possibility of applying machine learning techniques to the analysis of electromyographic patterns (EMG) collected from arthritic patients during gait. The EMG recordings were collected from the lower limbs of patients with arthritis and compared with those of healthy subjects (CO) with no musculoskeletal disorder. The study involved subjects suffering from two forms of arthritis, viz, rheumatoid arthritis (RA) and hip osteoarthritis (OA). The analysis of the data was plagued by two problems which frequently render the analysis of this type of data extremely difficult. One was the small number of human subjects that could be included in the in…
Artificial chromosomes for antibiotic-producing actinomycetes.
2000
Bacteria belonging to the order Actinomycetales produce most microbial metabolites thus far described, several of which have found applications in medicine and agriculture. However, most strains were discovered by their ability to produce a given molecule and are, therefore, poorly characterized physiologically and genetically. Thus, methodologies for genetic manipulation of actinomycetes are not available and efficient tools have been developed for just a few strains. This constitutes a serious limitation to applying molecular genetics approaches to strain development and structural manipulation of microbial metabolites. To overcome this hurdle, we have developed bacterial artificial chrom…
3D bioprinting of tissue units with mesenchymal stem cells, retaining their proliferative and differentiating potential, in polyphosphate-containing …
2021
Abstract The three-dimensional (3D)-printing processes reach increasing recognition as important fabrication techniques to meet the growing demands in tissue engineering. However, it is imperative to fabricate 3D tissue units, which contain cells that have the property to be regeneratively active. In most bio-inks, a metabolic energy-providing component is missing. Here a formulation of a bio-ink is described, which is enriched with polyphosphate (polyP), a metabolic energy providing physiological polymer. The bio-ink composed of a scaffold (N,O-carboxymethyl chitosan), a hydrogel (alginate) and a cell adhesion matrix (gelatin) as well as polyP substantially increases the viability and the …
Le projet SimAction
2011
Resume Le projet SimAction avait pour but de developper de nouvelles methodes d’aide au reentrainement moteur en exploitant les mecanismes de couplage entre perception et execution de l’action. L’objectif etait de creer des outils d’entrainement par observation complementaires aux methodes conventionnelles basees sur le reentrainement physique. Les outils developpes devaient dans un premier temps etre orientes vers une population âgee. Ce projet a permis un travail en interaction entre des physiologistes du mouvement, des cliniciens, des equipes de recherche specialisees en informatique, traitement de l’image, science cognitive et ergonomie, ainsi que deux industriels. Au cours de ce projet…
Le dossier médical personnel du patient : réflexions sur le portail d’accès unique et le masquage du dossier
2009
Resume Objectifs La loi de financement de la securite sociale du 19 decembre 2007 a precise deux principes fondamentaux du dossier medical personnel qui soulevent de nombreuses questions : le portail unique et le masquage des informations. Materiel et methodes Selon la loi, l’existence d’un portail permet « aux beneficiaires de l’Assurance maladie de gerer leur dossier medical personnel et les droits d’acces des professionnels de sante » et « assure le controle et la tracabilite des acces aux dossiers medicaux personnels ». Il s’agit d’un enjeu majeur tant pour la protection de la vie privee des patients que des promoteurs et des responsables du portail qui pourraient voir leur responsabili…
ANR Inforare : proposition d’un modèle d’identifiant patient individuel pour les patients drépanocytaires
2010
Resume Ce projet a comme objectifs d’organiser le partage d’information et d’evaluer son acceptation par les patients et par les professionnels. La methode repose sur : evaluation de l’acceptabilite du recueil des donnees familiales par les patients ; gestion centralisee de dossiers medicaux rendus anonymes ; proposition d’un modele d’identification du patient et evaluation de la faisabilite du recueil de l’identification et de la qualite du chainage des donnees. Resultats L’entretien semidirectif realise par le LEM a permis d’interroger 43 patients, six membres d’association et six professionnels de sante sur l’acceptabilite du recueil. La plateforme informatique permettant la gestion cent…