Search results for "Brain"

Human-to-human interfaces: emerging trends and challenges

2011

We present a new research domain, human-to-human interaction (HHI) that describes how today's human interaction is largely indirect and mediated by a wide variety of technologies and devices. We show how this new and exciting field of design originates from the convergence of a few well-established research areas, such as traditional graphical user interfaces (GUIs), tangible user interfaces (TUIs), touchless gesture user interfaces (TGUIs), voice user interfaces (VUIs), and brain computer interfaces (BCIs). We analyse and describe current research in those areas and offer a first-hand view and presentation of its salient aspects for the human-to human interaction domain.

The "political" brain:Marxian presuppositions in Vygotsky's psychology

2014

Active Ageing e Brain Gym: un percorso di formazione in Sicilia.

2022

L’interesse verso la tematica dell’invecchiamento attivo è in costante crescita, tanto a livello accademico che istituzionale, in ambito internazionale e nazionale. In quest’ottica l’OMS ha definito e sviluppato l’idea dell’Active Ageing (AA) come risposta concreta all’incremento della popolazione over 60 e alle sfide socioeconomiche ad esso connesse. Tuttavia, a livello nazionale si registrano ancora alcune criticità rispetto allo sviluppo di programmi integrati, diffusi e sistematici. In questo scenario si inserisce il progetto di ricerca “Prevenzione degli incidenti domestici e promozione dell'attività fisica delle persone over 60” promosso e coordinato dal partenariato tra l’ASP 6 di Pa…

Memory function after resolution of post traumatic amnesia

2005

Primary objectives: The aims of this pilot study were (1) to examine neuropsychological, particularly memory functions immediately after post-traumatic amnesia (PTA) resolution according to the Galveston Orientation and Amnesia Test (GOAT), and (2) to provide a preliminary exploration of pattern of performance on GOAT items across PTA duration. Methods and procedures: Thirty-seven head injured patients were administered the Recognition Memory Tests on the day that PTA resolved. Formal neuropsychological assessment was conducted on average 10 days after PTA resolution. Main outcomes and results: All the patients in the series showed memory impairment which varied in severity but was typicall…

Mind, brain and altered states of consciousness

2018

The consciousness is the expression of an enormous and complex variety of neurobiological events, phenomenological and psychological that, from the early stages of development, prepare the emergence soil of the Self. It is a complex of tangible and intan- gible characters distinct from one another - neural infrastructure, awareness, temporality, qualitative subjectivity, intentionality - to such an extent as to seem welded faces of the same prism. Consciousness is not a simple function of the mind, but its organization. In this paper we intend to show how its order is not strictly hierarchical, but sustained by multiple horizontal levels, each of which in a structural and functional continu…

Genetic risk factors and candidate biomarkers for Alzheimer s disease

2009

Alzheimer's disease is a multifactorial and progressive neurodegenerative disease, extremely diffused and with an increasing prevalence worldwide. There is an urgent need for biomarkers to diagnose AD early in its course. Furthermore, accurate biomarkers would be able to determine the clinical efficacy of novel neuroprotective strategies. Although the heritability of late-onset AD is high, our knowledge of the underlying putative susceptibility genes remains incomplete and the only unequivocally established late-onset AD gene is APOE. Nevertheless a number of susceptibility loci seems to influence the pathogenesis of AD, and variations in numerous genes have been considered to be important …

Rat CNS neurons are not yet programmed to shorten their chromatin repeat length at the end of fetal neurogenesis.

1986

Neurons from rat fetal cerebral hemispheres were grown in a synthetic medium (Maat medium), as previously described, for different periods of time. The repeat length of their chromatin was determined by micrococcal nuclease digestion and compared with that of neurons isolated from postnatal rat brain of corresponding ages. In contrast to the in vivo situation, we found that neurons, dissociated at the 16th gestational day and cultured in vitro, did not undergo the shortening of their chromatin repeat, thus indicating that, at the end of their mitotic cycles, they are not yet programmed to this event. © 1986.

Anidulafungin in combination with amphotericin B against Aspergillus fumigatus.

2009

ABSTRACT We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus . Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of mice with invasive aspergillosis. Anidulafungin at 5 mg/kg/day, alone and in combination with amphotericin B, reduced the kidney fungal burden. Overall, the combination was not superior to the most active single drug.

Developing drug strategies for the neuroprotective treatment of acute ischemic stroke

2015

Developing new treatment strategies for acute ischemic stroke in the last twenty years has offered some important successes, but also several failures. Most trials of neuroprotective therapies have been uniformly negative to date. Recent research has reported how excitatory amino acids act as the major excitatory neurotransmitters in the cerebral cortex and hippocampus. Furthermore, other therapeutic targets such as free radical scavenger strategies and the anti-inflammatory neuroprotective strategy have been evaluated with conflicting data in animal models and human subjects with acute ischemic stroke. Whereas promising combinations of neuroprotection and neurorecovery, such as citicoline,…

Pathogenetic Mechanisms of Hypertension-Brain-Induced Complications: Focus on Molecular Mediators.

2021

There is growing evidence that hypertension is the most important vascular risk factor for the development and progression of cardiovascular and cerebrovascular diseases. The brain is an early target of hypertension-induced organ damage and may manifest as stroke, subclinical cerebrovascular abnormalities and cognitive decline. The pathophysiological mechanisms of these harmful effects remain to be completely clarified. Hypertension is well known to alter the structure and function of cerebral blood vessels not only through its haemodynamics effects but also for its relationships with endothelial dysfunction, oxidative stress and inflammation. In the last several years, new possible mechani…