Search results for "C25"

Evaluación de las alteraciones psicológicas y de la calidad de vida en pacientes con cáncer colorrectal localizado

2016

En los paises desarrollados y en la mayoria del mundo industrializado, el cancer constituye uno de los mayores problemas de salud siendo una de las enfermedades mas prevalentes. En la actualidad, la estimacion en Espana sobre incidencia resalta que el cancer mas frecuente teniendo en cuenta ambos sexos, con una prevision a 5 anos, es el cancer colorrectal. El principal factor pronostico es el estadio clinico en el momento de la cirugia, pero en los ultimos anos se han desarrollado diversos programas de tratamiento adyuvante con quimioterapia y radioterapia para el cancer colorrectal. Un 70% de estos tumores son de localizacion proximal (colon), mientras que el resto son distales (recto). Es…

Cribado de distrés emocional en población oncológica adulta: validación de instrumentos

2017

La investigacion ha demostrado la presencia de niveles de distres (o malestar emocional) clinicamente significativos en aproximadamente tres de cada diez pacientes oncologicos (Mitchell et al., 2011). Sin embargo, en la actualidad, menos de la mitad de estos pacientes son identificados y derivados a los servicios de asistencia psicosocial (NCCN, 2015). El fracaso a la hora de detectar y tratar adecuadamente sus necesidades emocionales conlleva una serie de importantes consecuencias negativas que repercuten no solo en la calidad de vida de los pacientes (Shim et al., 2006) y en su nivel de satisfaccion con la atencion medica recibida (Von Essen, Larsson, Oberg y Sjoden, 2002), sino tambien e…

A Nomogram-Based Prognostic Model for Advanced Hepatocellular Carcinoma Patients Treated with Sorafenib: A Multicenter Study

2021

Simple Summary Accurate prognostic systems capable of predicting the survival of patients with advanced hepatocellular carcinoma undergoing Sorafenib therapy are still lacking. The search for the ideal predictive tool for survival and drug response is justified by the recent availability of several other drugs effective for these patients, licensed as first- and second-line treatment, other than reducing adverse events and costs. In this study, we aimed to identify simple demographic and clinical parameters able to predict survival and Sorafenib response in a large multicenter cohort. In this study, we showed that patient’s general status, liver function and damage laboratory parameters and…

Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection: effect of ACE-2 expression on tumor cells or molecul…

2021

Commuting powers and exterior degree of finite groups

2011

In [P. Niroomand, R. Rezaei, On the exterior degree of finite groups, Comm. Algebra 39 (2011), 335-343] it is introduced a group invariant, related to the number of elements $x$ and $y$ of a finite group $G$, such that $x \wedge y = 1_{G \wedge G}$ in the exterior square $G \wedge G$ of $G$. This number gives restrictions on the Schur multiplier of $G$ and, consequently, large classes of groups can be described. In the present paper we generalize the previous investigations on the topic, focusing on the number of elements of the form $h^m \wedge k$ of $H \wedge K$ such that $h^m \wedge k = 1_{H \wedge K}$, where $m \ge 1$ and $H$ and $K$ are arbitrary subgroups of $G$.

Accuracy and Safety of Ultrasound-Guided Core Needle Biopsy of Soft Tissue Tumors in an Outpatient Setting: A Sarcoma Center Analysis of 392 Consecut…

2021

Simple Summary In patients with unclear soft tissue lesions, treatment planning largely depends on histology. Core needle biopsy is the diagnostic standard in these cases. The aim of this retrospective study was to investigate accuracy and safety of ultrasound guided core needle biopsy at a tertiary referral center. We show that ultrasound guided biopsy was feasible as a one stop shop procedure in an outpatient setting in 87.6% of the cases. The rate of conclusive biopsies was 88.5%. After surgical resection, the dignity, tumor type and histopathological grading of the biopsy matched one of the resection specimens in 97.2%, 92.7% and 92.5% of the cases, respectively. Major complications occ…

Minimal unit vector fields

2002

We compute the first variation of the functional that assigns each unit vector field the volume of its image in the unit tangent bundle. It is shown that critical points are exactly those vector fields that determine a minimal immersion. We also find a necessary and sufficient condition that a vector field, defined in an open manifold, must fulfill to be minimal, and obtain a simpler equivalent condition when the vector field is Killing. The condition is fulfilled, in particular, by the characteristic vector field of a Sasakian manifold and by Hopf vector fields on spheres.

Therapeutic afucosylated monoclonal antibody and bispecific T-cell engagers for T-cell acute lymphoblastic leukemia

2021

BackgroundT-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease with a poor cure rate for relapsed/resistant patients. Due to the lack of T-cell restricted targetable antigens, effective immune-therapeutics are not presently available and the treatment of chemo-refractory T-ALL is still an unmet clinical need. To develop novel immune-therapy for T-ALL, we generated an afucosylated monoclonal antibody (mAb) (ahuUMG1) and two different bispecific T-cell engagers (BTCEs) against UMG1, a unique CD43-epitope highly and selectively expressed by T-ALL cells from pediatric and adult patients.MethodsUMG1 expression was assessed by immunohistochemistry (IHC) on a wide panel of normal t…

Evaluación y rehabilitación neuropsicológica en oncología pediátrica.

2003

Objetivo. El presente trabajo tiene como objetivo el estudio de los efectos neuropsicológicos a largo plazo del cáncer infantil y sus tratamientos así como plantear propuestas para la rehabilitación cognitiva. Método. El método ha consistido en una revisión sistemática de los resultados en la literatura científica acerca de los efectos de la quimioterapia y la radioterapia sobre el SNC y en las funciones cognitivas y conductuales detectados a través de estudios de neuroimagen como calcificaciones y cambios en la sustancia blanca. Presentamos, además, el protocolo de evaluación neuropsicológica ejemplificado con un diagnóstico frecuente que presenta deterioro generalizado. Proponemos un prog…

Functional Inactivation of pRB Results in Aneuploid Mammalian Cells After Release From a Mitotic Block

2002

AbstractThe widespread chromosome instability observed in tumors and in early stage carcinomas suggests that aneuploidy could be a prerequisite for cellular transformation and tumor initiation. Defects in tumor suppressers and genes that are part of mitotic checkpoints are likely candidates for the aneuploid phenotype. By using flow cytometric, cytogenetic, immunocytochemistry techniques we investigated whether pRB deficiency could drive perpetual aneuploidy in normal human and mouse fibroblasts after mitotic checkpoint challenge by microtubule-destabilizing drugs. Both mouse and human pRB-deficient primary fibroblasts resulted, upon release from a mitotic block, in proliferating aneuploid …