Search results for "C25"
showing 10 items of 566 documents
Weekly oxaliplatin, 5-fluorouracil and folinic acid (OXALF) as first-line chemotherapy for elderly patients with advanced gastric cancer: results of …
2006
Abstract Background Elderly patients have been often excluded from or underrepresented in the study populations of combination chemotherapy trials. The primary end point of this study was to determine the response rate and the toxicity of the weekly oxaliplatin, 5-fluorouracil and folinic acid (OXALF) regimen in elderly patients with advanced gastric cancer. The secondary objective was to measure the time to disease progression and the survival time. Methods Chemotherapy-naive patients with advanced gastric cancer aged 70 or older were considered eligible for study entry. Patients received weekly oxaliplatin 40 mg/m2, fluorouracil 500 mg/m2 and folinic acid 250 mg/m2. All drugs were given i…
Resection of the mesopancreas (RMP): a new surgical classification of a known anatomical space
2007
Abstract Background Prognosis after surgical therapy for pancreatic cancer is poor and has been attributed to early lymph node involvement as well as to a strong tendency of cancer cells to infiltrate into the retropancreatic tissue and to spread along the peripancreatic neural plexuses. The objective of our study was to classify the anatomical-surgical layer of the mesopancreas and to describe the surgical principles relevant for resection of the mesopancreas (RMP). Immunohistochemical investigation of the mesopancreatic-perineural lymphogenic structures was carried out with the purpose of identifying possible routes of metastatic spread. Methods Resection of the mesopancreas (RMP) was per…
Design of a randomized controlled trial of physical training and cancer ( Phys-Can) the impact of exercise intensity on cancer related fatigue, quali…
2017
Background: Cancer-related fatigue is a common problem in persons with cancer, influencing health-related quality of life and causing a considerable challenge to society. Current evidence supports the beneficial effects of physical exercise in reducing fatigue, but the results across studies are not consistent, especially in terms of exercise intensity. It is also unclear whether use of behaviour change techniques can further increase exercise adherence and maintain physical activity behaviour. This study will investigate whether exercise intensity affects fatigue and health related quality of life in persons undergoing adjuvant cancer treatment. In addition, to examine effects of exercise …
Exercise Adherence and Effect of Self-Regulatory Behavior Change Techniques in Patients Undergoing Curative Cancer Treatment: Secondary Analysis from…
2020
Introduction: Adherence to exercise interventions in patients with cancer is often poorly described. Further, it is unclear if self-regulatory behavior change techniques (BCTs) can improve exercise adherence in cancer populations. We aimed to (1) describe exercise adherence in terms of frequency, intensity, time, type (FITT-principles) and dropouts, and (2) determine the effect of specific self-regulatory BCTs on exercise adherence in patients participating in an exercise intervention during curative cancer treatment. Methods: This study was a secondary analysis using data from a Swedish multicentre RCT. In a 2×2 factorial design, 577 participants recently diagnosed with curable breast, col…
Equivalence of quasiregular mappings on subRiemannian manifolds via the Popp extension
2016
We show that all the common definitions of quasiregular mappings $f\colon M\to N$ between two equiregular subRiemannian manifolds of homogeneous dimension $Q\geq 2$ are quantitatively equivalent with precise dependences of the quasiregularity constants. As an immediate consequence, we obtain that if $f$ is $1$-quasiregular according to one of the definitions, then it is also $1$-quasiregular according to any other definition. In particular, this recovers a recent theorem of Capogna et al. on the equivalence of $1$-quasiconformal mappings. Our main results answer affirmatively a few open questions from the recent research. The main new ingredient in our proofs is the distortion estimates for…
Manifolds with vectorial torsion
2015
Abstract The present note deals with the properties of metric connections ∇ with vectorial torsion V on semi-Riemannian manifolds ( M n , g ) . We show that the ∇-curvature is symmetric if and only if V ♭ is closed, and that V ⊥ then defines an ( n − 1 ) -dimensional integrable distribution on M n . If the vector field V is exact, we show that the V-curvature coincides up to global rescaling with the Riemannian curvature of a conformally equivalent metric. We prove that it is possible to construct connections with vectorial torsion on warped products of arbitrary dimension matching a given Riemannian or Lorentzian curvature—for example, a V-Ricci-flat connection with vectorial torsion in di…
Tensorization of quasi-Hilbertian Sobolev spaces
2022
The tensorization problem for Sobolev spaces asks for a characterization of how the Sobolev space on a product metric measure space $X\times Y$ can be determined from its factors. We show that two natural descriptions of the Sobolev space from the literature coincide, $W^{1,2}(X\times Y)=J^{1,2}(X,Y)$, thus settling the tensorization problem for Sobolev spaces in the case $p=2$, when $X$ and $Y$ are infinitesimally quasi-Hilbertian, i.e. the Sobolev space $W^{1,2}$ admits an equivalent renorming by a Dirichlet form. This class includes in particular metric measure spaces $X,Y$ of finite Hausdorff dimension as well as infinitesimally Hilbertian spaces. More generally for $p\in (1,\infty)$ we…
Urysohn's metrization theorem for higher cardinals
2011
In this paper a generalization of Urysohn's metrization theorem is given for higher cardinals. Namely, it is shown that a topological space with a basis of cardinality at most $|\omega_\mu|$ or smaller is $\omega_\mu$-metrizable if and only if it is $\omega_\mu$-additive and regular, or, equivalently, $\omega_\mu$-additive, zero-dimensional, and T\textsubscript{0}. Furthermore, all such spaces are shown to be embeddable in a suitable generalization of Hilbert's cube.
Identification of an Immunogenic Medulloblastoma-Specific Fusion Involving EPC2 and GULP1
2021
Medulloblastoma is the most common malignant brain tumor in children. Immunotherapy is yet to demonstrate dramatic results in medulloblastoma, one reason being the low rate of mutations creating new antigens in this entity. In tumors with low mutational burden, gene fusions may represent a source of tumor-specific neoantigens. Here, we reviewed the landscape of fusions in medulloblastoma and analyzed their predicted immunogenicity. Furthermore, we described a new in-frame fusion protein identified by RNA-Seq. The fusion involved two genes on chromosome 2 coding for the enhancer of polycomb homolog 2 (EPC2) and GULP PTB domain containing engulfment adaptor 1 (GULP1) respectively. By qRT-PCR …
Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate
2021
Simple Summary Electric potential patterns across tissues are instructive for development, regeneration, and tumorigenesis because they can influence transcription, migration, and differentiation through biochemical and biomechanical downstream processes. Determining the origins of the spatial domains of distinct potential, which in turn decide anatomical features such as limbs, eyes, brain, and heart, is critical to a mature understanding of how bioelectric signaling drives morphogenesis. We studied theoretically how connexin proteins with different voltage-gated gap junction conductances can maintain multicellular regions at distinct membrane potentials. We analyzed a minimal model that i…