Search results for "C25"
showing 10 items of 566 documents
Pressurized intraperitoneal aerosol chemotherapy with cisplatin and doxorubicin or oxaliplatin for peritoneal metastasis from pancreatic adenocarcino…
2020
Background: Systemic chemotherapy for pancreatic adenocarcinoma (PDAC) and cholangiocarcinoma (CC) with peritoneal metastases (PM) is affected by several pharmacological shortcomings and low clinical efficacy. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is expected to maximize exposure of peritoneal nodules to antiblastic agents. This study aims to evaluate safety and efficacy of PIPAC for PM of PDAC and CC origin. Methods: This is a retrospective analysis of consecutive PDAC and CC cases with PM treated with PIPAC at two European referral centers for peritoneal disease. We prospectively recorded from August 2016 to May 2019 demographic, clinical, surgical, and oncological data…
Editorial debate: Challenges we oncologists, working within a universal healthcare system, have to face in these hard times
2020
I have been very much impressed by the clarity, pragmatism and good medical judgement of the article by Camilo Porta,1 a respected and dedicated ESMO faculty member and friend, giving his personal perspective on real issues many oncologists working in a public system are eventually facing during the SARS-CoV-2 pandemic. I understand Professor Porta is voicing what many oncologists from countries deeply affected by the pandemic, such as Italy or Spain, may think. Although I concur with most of his approaches and comments, I would like to complement some of these statements with some additional thoughts. Medicine was created more than 2500 years ago as a profession aiming at alleviating suffe…
Predictores de duelo complicado
2008
Pilar.Barreto@uv.es; Patricia.Yi@uv.es OBJETIVO: Estudiar el proceso de evolución en sus primeras etapas tras la pérdida y determinar cuáles son los factores de riesgo y protección previos a la muerte que permiten predecir el surgimiento de posibles complicaciones en los familiares/cuidadores de pacientes oncológicos. MÉTODO: Se evaluaron 236 dolientes cuyos familiares eran pacientes oncológicos atendidos en servicios de cuidados paliativos de Valencia y Madrid y se realizó un seguimiento en 2 momentos temporales: 2 y 6 meses tras la muerte, evaluándose la presencia/ausencia de complicaciones en el proceso de duelo mediante dos criterios diagnósticos (DSM e ICG). RESULTADOS: Se encontró una…
On Cancer Cell Cycle and Universal Apoptosis Parameters Signaling Unravelled In Silico
2010
Here, cell cycle in higher eukaryotes and their molecular networks signals both in G1/S and G2/M transitions are in silico replicated. Systems control theory is employed to design multi-nestled digital layers to simulate protein-to- protein activation and inhibition in the cancer cell cycle dynamics in presence of damaged genome. Sequencing and controlling the digital process of four micro-scale species networks (p53/Mdm2/DNA damage; p21mRNA/cyclin-CDK complex; CDK/CDC25/wee1/SKP2/APC/CKI and apoptosis target genes system) paved the way for unravelling the participants and their by-products having the task to execute (or not) cell death. The results of the proposed cell digital multi-layers…
Outcomes of Patients With Advanced NSCLC From the Intergroupe Francophone de Cancérologie Thoracique Biomarkers France Study by KRAS Mutation Subtypes
2020
Abstract Introduction KRAS mutations are detected in 20% to 30% of NSCLC. However, KRAS mutation subtypes may differently influence the outcome of patients with advanced NSCLC. Methods In the Biomarkers France study, 4894 KRAS mutations (26.2%) were detected in 4634 patients from the 17,664 enrolled patients with NSCLC. Survival and treatment data on noncurative stage III to IV NSCLC were available for 901 patients. First- and second-line treatment effects on progression-free survival and overall survival were analyzed according to the KRAS mutations subtype. Results Over 95% of patients with KRAS mutation were smokers or former smokers who were white (99.5%), presenting with adenocarcinoma…
Existence of common zeros for commuting vector fields on 3‐manifolds II. Solving global difficulties
2020
We address the following conjecture about the existence of common zeros for commuting vector fields in dimension three: if $X,Y$ are two $C^1$ commuting vector fields on a $3$-manifold $M$, and $U$ is a relatively compact open such that $X$ does not vanish on the boundary of $U$ and has a non vanishing Poincar\'e-Hopf index in $U$, then $X$ and $Y$ have a common zero inside $U$. We prove this conjecture when $X$ and $Y$ are of class $C^3$ and every periodic orbit of $Y$ along which $X$ and $Y$ are collinear is partially hyperbolic. We also prove the conjecture, still in the $C^3$ setting, assuming that the flow $Y$ leaves invariant a transverse plane field. These results shed new light on t…
On the existence of attractors
2009
On every compact 3-manifold, we build a non-empty open set $\cU$ of $\Diff^1(M)$ such that, for every $r\geq 1$, every $C^r$-generic diffeomorphism $f\in\cU\cap \Diff^r(M)$ has no topological attractors. On higher dimensional manifolds, one may require that $f$ has neither topological attractors nor topological repellers. Our examples have finitely many quasi attractors. For flows, we may require that these quasi attractors contain singular points. Finally we discuss alternative definitions of attractors which may be better adapted to generic dynamics.
Heterogeneity in general practitioners’ preferences for quality improvement programs: a choice experiment and policy simulation in France
2016
International audience; Despite increasing popularity, quality improvement programs (QIP) have had modest and variable impacts on enhancing the quality of physician practice. We investigate the heterogeneity of physicians’ preferences as a potential explanation of these mixed results in France, where the national voluntary QIP – the CAPI – has been cancelled due to its unpopularity. We rely on a discrete choice experiment to elicit heterogeneity in physicians’ preferences for the financial and non-financial components of QIP. Using mixed and latent class logit models, results show that the two models should be used in concert to shed light on different aspects of the heterogeneity in prefer…
Management of Spinal Bone Metastases With Radiofrequency Ablation, Vertebral Reinforcement and Transpedicular Fixation: A Retrospective Single-Center…
2022
Spine is a frequent site of bone metastases, with a 8.5 months median survival time after diagnosis. In most cases treatment is only palliative. Several advanced techniques can ensure a better Quality of Life (QoL) and increase life expectancy. Radiofrequency ablation (RFA) uses alternating current to produce local heating and necrosis of the spinal lesion, preserving the healthy bone. RFA is supported by vertebral reinforcement through kyphoplasty and vertebroplasty in order to stabilize the fracture with polymethylmethacrylate (PMMA) injection, restoring vertebral body height and reducing the weakness of healthy bone. The aim of this study is to demonstrate the efficacy and advantages of …
La realidad virtual en las intervenciones psicológicas con pacientes oncológicos
2014
El objetivo de este trabajo es presentar las principales aportaciones de la Realidad Virtual (RV) en el tratamiento psicologico con pacientes oncologicos, y describir un programa de intervencion que utiliza esta tecnologia para promover bienestar emocional en pacientes hospitalizados. La RV se presenta como una prometedora herramienta de apoyo al paciente oncologico. Diversos estudios plantean su utilidad para hacer algunos tratamientos medicos mas tolerables, para reducir los niveles de distres y dolor, asi como promover mayores niveles de emociones positivas. Se ha empleado principalmente con pacientes ambulatorios, existiendo una menor proporcion de propuestas dirigidas al periodo de hos…